RecruitingPhase IEN originalLymphoma

A Study of ARV-393 in Relapsed/Refractory Non-Hodgkin Lymphoma.

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This clinical trial is studying the safety and potential anti-tumor activity of an investigational drug called ARV-393 in patients diagnosed with advanced Relapsed/Refractory non-Hodgkin's lymphoma (R/R NHL) to determine if ARV-393 may be a possible treatment option. ARV-393 is thought to work by breaking down a protein present in many types of non-Hodgkins lymphomas, which may prevent, slow or stop tumor growth. This is the first time ARV-393 will be used by people. The investigational drug will be given as an oral tablet.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony nawrotowy lub oporny chłoniak nieziarniczy, który nie reaguje na dotychczasowe leczenie
  • Wcześniejsze leczenie co najmniej dwoma rodzajami chemioterapii (w tym rituximabem)
  • Nienadający się do innych znanych terapii selon oceny lekarza
  • Co najmniej jeden widoczny na obrazach guz o wielkości ponad 1,5 cm
  • Dobry ogólny stan zdrowia (skala ECOG 0 lub 1)
  • Prawidłowe funkcje nerek, wątroby i szpiku kostnego

✗ Disqualifies

  • Historia zwiększonego poziomu eozynofilów we krwi lub zespół hipereozynofilii
  • Wcześniejsza transplantacja komórek macierzystych lub organów
  • Leczenie terapią CAR-T w ciągu ostatnich 60 dni
  • Inny nowotwór w ciągu ostatnich 3 lat (poza rakami skóry)
  • Zawał serca w ciągu ostatnich 6 miesięcy
  • Rodzinna historia zespołu wydłużonego QT

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 26, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (19)

Clinical Trial Site

New Haven, United States

Clinical Trial Site

Miami, United States

Clinical Trial Site

Detroit, United States

Clinical Trial Site

New Brunswick, United States

Clinical Trial Site

New York, United States

Clinical Trial Site

New York, United States

Clinical Trial Site

Cleveland, United States

Clinical Trial Site

Nashville, United States

Clinical Trial Site

Houston, United States

Clinical Trial Site

Charlottesville, United States

Clinical Trial Site

Toronto, Canada

Clinical Trial Site

Montreal, Canada

Clinical Trial Site

Copenhagen, Denmark

Clinical Trial Site

Odense C, Denmark

Clinical Trial Site

El Palmar, Spain

Clinical Trial Site

Pamplona, Spain

Clinical Trial Site

Barcelona, Spain

Clinical Trial Site

Madrid, Spain

Clinical Trial Site

Salamanca, Spain

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/27/2026.

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