A Study of Avutometinib, Defactinib, and Letrozole in People With Low-Grade Serous Ovarian Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The researchers are doing this study to find out whether the combination of avutometinib, defactinib, and letrozole is an effective treatment for people with low-grade serous ovarian cancer (LGSOC). The researchers will also look at the safety of this combination.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku 18 lat lub starsza
- •Potwierdzone rozpoznanie raka jajnika niskiego stopnia złośliwości (jajnik lub błona otrzewnowa)
- •Lekarz uważa, że nie nadajesz się do operacji, lub operacja już się odbyła, ale nowotwór pozostał
- •Widoczne, mierzalne zmiany guza na badaniach (CT lub MRI)
- •Dobry ogólny stan zdrowia (ECOG 0-1)
- •Jeśli masz przerzuty do mózgu, muszą być ustabilizowane po leczeniu
- •Jeśli masz HIV, musi być ono kontrolowane lekami i niewykrywalne w badaniach
- •Jeśli masz zapalenie wątroby B lub C, musi być ono kontrolowane lub wyleczone
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 20, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (8)
Emory Winship Cancer Institute
Atlanta, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Suffolk -Commack (Limited Protocol Activities)
Commack, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
East White Plains, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, United States
Trial contact
Rachel Grisham, MD
Chrisann Kyi, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/21/2026.
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