Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Substudy 01A is part of a platform study. The purpose of this study is to assess the efficacy and safety of zilovertamab vedotin in pediatric participants with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL), diffuse large B-cell lymphoma (DLBCL)/Burkitt lymphoma, or neuroblastoma and in pediatric and young adult participants with Ewing sarcoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza białaczki limfoblastycznej lub chłoniaka komórek B (DLBCL/chłoniak Burkitta)
- •Potwierdzona histologicznie diagnoza neuroblastomy lub mięsiaka Ewinga
- •Nowotwór, który wrócił lub nie odpowiada na poprzednie leczenie
✗ Disqualifies
- •Historia przeszczepienia narządu
- •Aktywna choroba serca
- •Zapalenie nerek (neuropatia obwodowa) stopnia wyższego niż 1
- •Zespół Downa
- •Choroba przeszczepionego narządu wobec gospodarza (GVHD)
- •Zakażenie HIV
- •Alergia na składniki badanego leku
- •Poprzednia radioterapia w ciągu 4 tygodni przed badaniem
Simplified criteria — AI translation
Trial details
- Minimum age
- 6 Months
- Maximum age
- 25 Years
- Last updated (source)
- July 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (71)
Children's Hospital Los Angeles ( Site 1006)
Los Angeles, United States
Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 1016)
Aurora, United States
Yale New Haven Hospital ( Site 1012)
New Haven, United States
Johns Hopkins All Children's Hospital ( Site 1025)
St. Petersburg, United States
University of Iowa-Holden Comprehensive Cancer Center ( Site 1017)
Iowa City, United States
Dana-Farber Cancer Institute ( Site 1013)
Boston, United States
Corewell Health ( Site 1001)
Grand Rapids, United States
Children's Mercy Hospital ( Site 1024)
Kansas City, United States
Rutgers Cancer Institute of New Jersey ( Site 1008)
New Brunswick, United States
Memorial Sloan Kettering Cancer Center ( Site 1010)
New York, United States
New York Medical College ( Site 1023)
Valhalla, United States
Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 1003)
Fargo, United States
Oregon Health and Science University ( Site 1004)
Portland, United States
Children's Hospital of Philadelphia (CHOP) ( Site 1021)
Philadelphia, United States
Sanford Children's Hospital-Sanford Children's Specialty Clinic ( Site 1015)
Sioux Falls, United States
University of Texas MD Anderson Cancer Center ( Site 1007)
Houston, United States
Intermountain - Primary Children's Hospital ( Site 1014)
Salt Lake City, United States
Sydney Children's Hospital ( Site 1997)
Randwick, Australia
Queensland Children's Hospital-Oncology & Haematology ( Site 1996)
Brisbane, Australia
Royal Children's Hospital-Children's Cancer Centre ( Site 1994)
Melbourne, Australia
UZ Gent ( Site 1428)
Ghent, Belgium
Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1268)
Curitiba, Brazil
Hospital de Clinicas de Porto Alegre ( Site 1265)
Porto Alegre, Brazil
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1264)
Barretos, Brazil
Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1267)
São José do Rio Preto, Brazil
Alberta Children's Hospital ( Site 1227)
Calgary, Canada
The Hospital for Sick Children ( Site 1225)
Toronto, Canada
McGill University Health Centre-Pediatric HematologyOncology ( Site 1223)
Montreal, Canada
Hospital Clínico Regional Dr. Guillermo Grant Benavente ( Site 1881)
Concepción, Chile
Hospital Luis Calvo Mackenna ( Site 1879)
Santiago, Chile
Hospital Carlos Van Buren ( Site 1880)
Valparaíso, Chile
Hospital Pablo Tobon Uribe ( Site 1923)
Medellín, Colombia
Clinica de la Costa S.A.S.-Clinical Research Oncology & Hematology -Pediatric ( Site 1924)
Barranquilla, Colombia
IMAT S.A.S ( Site 1921)
Montería, Colombia
Detska nemocnice FN Brno ( Site 1388)
Brno, Czechia
Fakultni nemocnice v Motole-Klinika detske hematologie a onkologie ( Site 1387)
Prague, Czechia
Rigshospitalet-Department of paediatrics and adolescent medicine, Section of Paed haem-onc ( Site 1467)
Copenhagen, Denmark
CHU de Bordeaux. Hopital Pellegrin ( Site 1105)
Bordeaux, France
CENTRE LEON BERARD-IHOPE (pediatrric oncology) ( Site 1100)
Lyon, France
Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1104)
Nantes, France
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1102)
Marseille, France
Gustave Roussy ( Site 1103)
Villejuif, France
Universitaetsklinikum Tuebingen ( Site 1142)
Tübingen, Germany
Universitaetsklinikum Koeln. Klinik und Poliklinik ( Site 1145)
Cologne, Germany
Universitätsklinikum Münster - Albert Schweitzer Campus-Pädiatrische Hämatologie und Onkologie ( Site 1141)
Münster, Germany
Charité Campus Virchow-Klinikum-Klinik für Pädiatrie mit Schwerpunkt Hämatologie und Onkologie ( Site 1143)
Berlin, Germany
Aghia Sophia Children's Hospital-First Department of Pediatrics, National and Kapodistrian Universi ( Site 1797)
Athens, Greece
Semmelweis Egyetem ( Site 1838)
Budapest, Hungary
Rambam Health Care Campus-Pediatric Hemato-Oncology ( Site 1674)
Haifa, Israel
Sheba Medical Center ( Site 1675)
Ramat Gan, Israel
Fondazione IRCCS Istituto Nazionale dei Tumori-Pediatric Oncology ( Site 1552)
Milan, Italy
Ospedale Pediatrico Bambino Gesù IRCCS-Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica ( Site 1553)
Rome, Italy
Ospedale Infantile Regina Margherita-S.C. Oncoematologia Pediatrica ( Site 1551)
Torino, Italy
Prinses Maxima Centrum voor Kinderoncologie ( Site 1510)
Utrecht, Netherlands
Narodny ustav detskych chorob ( Site 1592)
Bratislava, Slovakia
Seoul National University Hospital-Pediatrics ( Site 1972)
Seoul, South Korea
Asan Medical Center-Pediatrics - Pedicatric Oncology ( Site 1973)
Seoul, South Korea
Hospital Sant Joan de Déu-Pediatric Oncology Department ( Site 1717)
Esplugas de Llobregat, Spain
Hospital Infantil Universitario Niño Jesús-Servicio de Onco-Hematología Pediátrica ( Site 1715)
Madrid, Spain
Hospital Universitario y Politecnico La Fe de Valencia ( Site 1718)
Valencia, Spain
Hospital Universitari Vall d'Hebron-Servei de Hematologia i Oncologia Pediatrica ( Site 1716)
Barcelona, Spain
Sahlgrenska Universitetssjukhuset ( Site 1634)
Gothenburg, Sweden
National Taiwan University Hospital ( Site 1983)
Taipei, Taiwan
Ege Universitesi Hastanesi ( Site 1963)
Bornova, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 1961)
Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 1962)
Ankara, Turkey (Türkiye)
Birmingham Children's Hospital-Oncology/Haematology ( Site 1349)
Birmingham, United Kingdom
Royal Victoria Infirmary-Great North Children's Hospital ( Site 1348)
Newcastle upon Tyne, United Kingdom
University College London Hospital ( Site 1350)
London, United Kingdom
Royal Marsden Hospital (Sutton)-Drug Development Unit ( Site 1347)
Sutton, United Kingdom
University Hospital of Wales ( Site 1346)
Cardiff, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/28/2026.
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