Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase II, single cohort study designed to evaluate outcomes in patients with muscle invasive bladder cancer (MIBC) with variant histology who receive neoadjuvant chemotherapy (NAC) with or without immunotherapy (IO) followed by trimodal therapy (TMT). Enrolled patients will undergo at least 3 cycles of NAC +/- IO (oncologist's choice) followed by a four- or six-week course of concurrent standard of care chemotherapy and radiation therapy. These patients will be compared with historical controls of patients with a diagnosis of pure urothelial carcinoma who have undergone TMT. This study has been designed to test the hypothesis that variant histology TMT can be delivered within 45 days of NAC +/- IO and is therefore a viable option in patients who are risk of systemic disease spread.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnoza raka pęcherza moczowego z nienormalnymi komórkami nowotworowymi
- •Guz znajduje się w mięśniu pęcherza (stopień zaawansowania cT2-T4N0M0)
- •Przeprowadzona procedura pobrania próbki z pęcherza (TURBT) i badania obrazowe (CT, PET)
- •Napisana zgoda na uczestnictwo w badaniu
✗ Disqualifies
- •Obecność rozsianych zmian nowotworowych w pęcherzu (diffuse cis)
- •Obustronny zator moczowodu spowodowany opuchlizną
- •Wcześniejsza radioterapia miednicy
- •Poprzednie leczenie chemioterapią tego nowotworu
- •Obecny lub niedawny (w ciągu ostatnich 5 lat) inny nowotwór
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 6, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Cedars Sinai Medical Center
Los Angeles, United States
Trial contact
Clinical Trial Navigator
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/7/2026.
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