Minimally Interventional Study on Prevalence of Emerging ESR1 Mutations in Liquid Biopsy in Three Cohorts of Patients With Breast Cancer in Comparison With Patient's Baseline ESR1 Mutation Status as Defined by Tissue Profiling.
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Minimally interventional study on prevalence of emerging ESR1 mutations in liquid biopsy in three cohorts of patients with breast cancer (with and without prior therapies in metastatic setting, and during first-line aromatase inhibitor plus CDK4/6 inhibitor therapy) in comparison with patient's baseline ESR1 mutation status as defined by tissue profiling.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjenci z rakiem piersi (mężczyźni i kobiety), w wieku 18 lat i starsi
- •Przed lub po menopauzie
- •Z dodatnim receptorem hormonalnym (HR+) i ujemnym HER-2 (potwierdzone centralnie)
- •Ze zmianami zaawansowanymi, które nie można operować, i/lub przerzutami
- •Kwalifikujący się do terapii CDK4/6i w połączeniu z terapią hormonalną jako leczenie pierwszej linii
- •Mogą mieć poprzednią chemioterapię w zaawansowanej chorobie, ale bez wcześniejszej terapii hormonalnej w fazie zaawansowanej
- •Mogą mieć wcześniejszą chemioterapię lub terapię hormonalną w leczeniu przedoperacyjnym/pooperacyjnym
- •Muszą wyrazić pisemną zgodę na udział w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 100 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Locations (6)
Ensino E Terapia de Inovação Clínica Amo - Ética
Salvador, Brazil
Irmandade Da Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, Brazil
Fundação Antonio Prudente - A.C. Camargo Cancer Center
São Paulo, Brazil
Instituto D'Or de Pesquisa E Ensino - São Paulo
São Paulo, Brazil
Research Site
São Paulo, Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Eisntein
São Paulo, Brazil
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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