RecruitingPhase III🇵🇱 PolandEN original

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony rak płuca, typ płaskonabłonkowy, w stadium zaawansowanym (przerzuty).
  • Choroba widoczna w badaniach obrazowych.
  • Oczekiwana długość życia pacjenta to co najmniej 3 miesiące.
  • Pacjent jest w dobrym stanie ogólnym (nie jest bardzo osłabiony).
  • Dostępna próbka tkanki guza (z biopsji lub usunięcia).
  • Pacjenci z HIV muszą mieć dobrze kontrolowane zakażenie.
  • Pacjenci z aktywnym zapaleniem wątroby typu B muszą być pod opieką lekarza i mieć niewykrywalną ilość wirusa.
  • Pacjenci, którzy mieli wcześniejsze leczenie przeciwnowotworowe, muszą mieć większość skutków ubocznych wyleczonych lub złagodzonych.

✗ Disqualifies

  • Guzy, które nie są typu płaskonabłonkowego.
  • Choroba nie jest widoczna w badaniach obrazowych.
  • Zbyt krótki przewidywany czas życia pacjenta.
  • Pacjent jest w bardzo złym stanie ogólnym (duże osłabienie).
  • Guzy, które były wcześniej leczone radioterapią.
  • Niekontrolowane zakażenie HIV.
  • Aktywne lub niekontrolowane zakażenie wirusem zapalenia wątroby typu B.
  • Niektóre ciężkie skutki uboczne po wcześniejszych terapiach, które nie ustąpiły.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
June 29, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (212)

CARTI Cancer Center ( Site 0006)

Little Rock, United States

Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122)

Burbank, United States

Sharp Memorial Hospital ( Site 9544)

San Diego, United States

Intermountain Health Cancer Center Lutheran Hospital ( Site 0119)

Golden, United States

Intermountain Health St. Mary's Regional Hospital ( Site 0116)

Grand Junction, United States

Washington Hospital Center ( Site 0037)

Washington D.C., United States

Mid Florida Hematology and Oncology Center ( Site 0109)

Orange City, United States

Centricity Research Columbus Cancer Center ( Site 0111)

Columbus, United States

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001)

Marietta, United States

Southeastern Regional Medical Center ( Site 0004)

Newnan, United States

University of Chicago Medical Center ( Site 0145)

Chicago, United States

Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146)

Minneapolis, United States

Capital Health Medical Center - Hopewell ( Site 0034)

Pennington, United States

New Mexico Oncology Hematology Consultants Ltd. ( Site 0123)

Albuquerque, United States

University of New Mexico Comprehensive Cancer Center ( Site 0135)

Albuquerque, United States

St Luke's University Health Network ( Site 0017)

Bethlehem, United States

Thomas Jefferson University - Clinical Research Institute ( Site 0147)

Philadelphia, United States

Memorial Hermann Cancer Center ( Site 0015)

Houston, United States

Oncology Consultants P.A. ( Site 0124)

Houston, United States

Mays Cancer Center ( Site 0132)

San Antonio, United States

Instituto Alexander Fleming ( Site 0203)

Ciudad Autónoma de Buenos Aires, Argentina

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0200)

Mar del Plata, Argentina

Instituto Médico Río Cuarto ( Site 0204)

Río Cuarto, Argentina

Fundacion Intecnus ( Site 0205)

Bariloche, Argentina

Sanatorio Parque ( Site 0201)

Rosario, Argentina

Hospital Aleman-Oncology ( Site 0202)

Buenos Aires, Argentina

Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0720)

Linz, Austria

Klinik Hietzing ( Site 0740)

Vienna, Austria

Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0730)

Vienna, Austria

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0710)

Vienna, Austria

Hospital do Cancer de Pernambuco ( Site 0312)

Recife, Brazil

Vencer Centro de Pesquisa Clínica ( Site 0309)

Teresina, Brazil

Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0311)

Porto Alegre, Brazil

Hospital Nossa Senhora da Conceição ( Site 0300)

Porto Alegre, Brazil

Instituto de Oncologia Saint Gallen ( Site 0304)

Santa Cruz do Sul, Brazil

Hospital de Base de São José do Rio Preto ( Site 0310)

São José do Rio Preto, Brazil

Hospital Paulistano ( Site 0307)

São Paulo, Brazil

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0100)

Kingston, Canada

Waterloo Regional Health Network (WRHN) ( Site 0153)

Kitchener, Canada

St. Marys Hospital Center ( Site 0105)

Montreal, Canada

McGill University Health Centre ( Site 0103)

Montreal, Canada

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0106)

Trois-Rivières, Canada

Centro de Investigación del Maule ( Site 0419)

Talca, Chile

FALP ( Site 0409)

Santiago, Chile

Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0402)

Santiago, Chile

Bradfordhill-Clinical Area ( Site 0407)

Santiago, Chile

ONCOCENTRO APYS-ACEREY ( Site 0400)

Viña del Mar, Chile

Bradford Hill Norte ( Site 0420)

Antofagasta, Chile

Beijing Cancer Hospital ( Site 2411)

Beijing, China

Beijing Cancer hospital-intrathoratic deparmtment II ( Site 2410)

Beijing, China

Peking Union Medical College Hospital ( Site 2412)

Beijing, China

Army Medical Center of People's Liberation Army-respiratory ( Site 2426)

Chongqing, China

Fujian Provincial Cancer Hospital ( Site 2419)

Fuzhou, China

The First Affiliated hospital of Xiamen University-oncology ( Site 2420)

Xiamen, China

The First Affiliated Hospital of Guangzhou Medical University ( Site 2417)

Guangzhou, China

Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 2416)

Guangzhou, China

Harbin Medical University Cancer Hospital-oncology of department ( Site 2415)

Harbin, China

Henan Cancer Hospital-Pneumology department ( Site 2423)

Zhengzhou, China

Tongji Hospital Tongji Medical,Science & Technology ( Site 2424)

Wuhan, China

The Second Xiangya Hospital of Central South University-Oncology ( Site 2418)

Changsha, China

First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 2402)

Huai'an, China

Northern Jiangsu People's Hospital-General Surgery Department ( Site 2403)

Yangzhou, China

The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2405)

Nanchang, China

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 2404)

Nanchang, China

Jilin Province Tumor Hospital-GCP office ( Site 2413)

Changchun, China

The First Hospital of Jilin University-Oncology ( Site 2414)

Changchun, China

Shanghai East Hospital ( Site 2428)

Shanghai, China

Shanghai Pulmonary Hospital ( Site 2427)

Shanghai, China

West China Hospital, Sichuan University ( Site 2422)

Chengdu, China

Sichuan Cancer hospital. ( Site 2421)

Chengdu, China

The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 2425)

Ürümqi, China

The first Affiliated Hospital, Zhejiang University School of Medicine-Respiratory Department ( Site 2406)

Hangzhou, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 2407)

Hangzhou, China

Zhejiang Cancer Hospital-Breast Oncology ( Site 2408)

Hangzhou, China

Taizhou Hospital of Zhejiang Province ( Site 2430)

Taizhou, China

The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 2409)

Wenzhou, China

Centro Cancerológico del Caribe (CECAC) ( Site 0509)

Barranquilla, Colombia

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0500)

Bogotá, Colombia

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501)

Valledupar, Colombia

Oncologos del Occidente ( Site 0504)

Pereira, Colombia

Fundación Valle del Lili-Oncology CIC ( Site 0505)

Cali, Colombia

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0800)

Brno, Czechia

Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 0803)

Ostrava-Vitkovice, Czechia

Multiscan-Onkologicke a radiologicke centrum Multiscan Pardubice ( Site 0804)

Pardubice, Czechia

Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0802)

Olomouc, Czechia

Clinique Clairval ( Site 0904)

Marseille, France

Hôpital Robert Schuman ( Site 0907)

Vantoux, France

Institut de Cancérologie de l'Ouest ( Site 0908)

Angers, France

Sainte Catherine Institut du Cancer Avignon Provence ( Site 0902)

Avignon, France

CHD Vendee ( Site 0901)

La Roche-sur-Yon, France

Hôpital Saint-Louis ( Site 0906)

Paris, France

GEFOS Gesellschaft f. onkologische Studien ( Site 1005)

Dortmund, Germany

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 1001)

Essen, Germany

Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 1000)

Lübeck, Germany

SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1006)

Gera, Germany

Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1003)

Berlin, Germany

Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 1100)

Kecskemét, Hungary

Petz Aladar Egyetemi Oktato Korhaz ( Site 1101)

Győr, Hungary

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 1103)

Szolnok, Hungary

Reformatus Pulmonologiai Centrum ( Site 1102)

Törökbálint, Hungary

Zala Megyei Szent Rafael Kórház ( Site 1110)

Zalaegerszeg, Hungary

Országos Korányi Pulmonológiai Intézet ( Site 1104)

Budapest, Hungary

St. James's Hospital ( Site 1200)

Dublin, Ireland

Rambam Health Care Campus-Oncology Division ( Site 1302)

Haifa, Israel

Shaare Zedek Medical Center ( Site 1300)

Jerusalem, Israel

Rabin Medical Center ( Site 1303)

Petah Tikva, Israel

Sheba Medical Center ( Site 1301)

Ramat Gan, Israel

Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1401)

Naples, Italy

Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1409)

Rome, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1404)

Milan, Italy

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 1412)

Monza, Italy

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1408)

Rozzano, Italy

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1402)

Rome, Italy

Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1414)

Brescia, Italy

Ospedale San Martino ( Site 1407)

Genova, Italy

Azienda Ospedaliera Maggiore della Carita ( Site 1416)

Novara, Italy

Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 1410)

Pavia, Italy

Ospedale di Circolo e Fondazione Macchi Varese-Oncology ( Site 1413)

Varese, Italy

Centro Ricerche Cliniche di Verona s.r.l. c/o Policlinico G.B.Rossi ( Site 1415)

Verona, Italy

Aichi Cancer Center ( Site 2502)

Nagoya, Japan

Nagoya University Hospital ( Site 2519)

Nagoya, Japan

Fujita Health University Hospital ( Site 2515)

Toyoake, Japan

Hirosaki University Hospital ( Site 2514)

Hirosaki, Japan

National Cancer Center Hospital East ( Site 2501)

Kashiwa, Japan

Ehime University Hospital ( Site 2511)

Tōon, Japan

Gunma Prefectural Cancer Center ( Site 2510)

Ōta, Japan

Kobe Minimally Invasive Cancer Center ( Site 2528)

Kobe, Japan

Takarazuka City Hospital ( Site 2508)

Takarazuka, Japan

Kanazawa University Hospital ( Site 2513)

Kanazawa, Japan

St. Marianna University Hospital ( Site 2521)

Kawasaki, Japan

Kanagawa Cardiovascular and Respiratory Center ( Site 2518)

Yokohama, Japan

Kanagawa Cancer Center ( Site 2504)

Yokohama, Japan

Kochi Medical School Hospital ( Site 2526)

Nankoku, Japan

Saiseikai Matsusaka Municipal Hospital ( Site 2522)

Matsusaka, Japan

Tohoku University Hospital ( Site 2525)

Sendai, Japan

Sendai Kousei Hospital ( Site 2507)

Sendai, Japan

Kansai Medical University Hospital ( Site 2503)

Hirakata, Japan

National Hospital Organization Ureshino Medical Center ( Site 2524)

Ureshino, Japan

Saitama Prefectural Cancer Center ( Site 2512)

Kitaadachi-gun, Japan

Cancer Institute Hospital of JFCR ( Site 2500)

Koto, Japan

Toho University Omori Medical Center ( Site 2520)

Ōta-ku, Japan

National Center for Global Health and Medicine ( Site 2516)

Shinjuku, Japan

National Hospital Organization Yamaguchi Ube Medical Center ( Site 2523)

Ube, Japan

Chiba University Hospital ( Site 2517)

Chiba, Japan

National Hospital Organization Kyushu Medical Center ( Site 2509)

Fukuoka, Japan

Niigata Cancer Center Hospital ( Site 2505)

Niigata, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2506)

Osaka, Japan

Clínica San Antonio ( Site 0606)

Trujillo, Peru

Clínicas AUNA Sede Chiclayo ( Site 0604)

Chiclayo, Peru

Oncosalud-Clinical Research ( Site 0600)

Lima, Peru

Hospital Militar Central Coronel Luis Arias Schereiber ( Site 0602)

Lima, Peru

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1503)

Bydgoszcz, Poland

Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1513)

Grudziądz, Poland

Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1507)

Gorlice, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1515)

Krakow, Poland

Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 1510)

Poznań, Poland

Instytut Gruzlicy i Chorob Pluc w Warszawie ( Site 1523)

Warsaw, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1500)

Warsaw, Poland

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1501)

Przemyśl, Poland

Bialostockie Centrum Onkologii ( Site 1520)

Bialystok, Poland

Szpital Wojewódzki w Koszalinie. ( Site 1517)

Poland, Poland

Centrul Medical Medicover Victoria ( Site 2000)

Bucharest, Romania

Cardiomed SRL Cluj-Napoca ( Site 2002)

Cluj-Napoca, Romania

SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2001)

Florești, Romania

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2004)

Craiova, Romania

Cabinet Medical Oncomed ( Site 2005)

Timișoara, Romania

SC ONCO CARD SRL ( Site 2007)

Brasov, Romania

Lotus-Med ( Site 2009)

Bucharest, Romania

Clinica Polisano ( Site 2008)

Sibiu, Romania

The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 2106)

Bupyeong-gu, South Korea

Pusan National University Yangsan Hospital ( Site 2104)

Yangsan, South Korea

Pusan National University Hospital ( Site 2100)

Busan, South Korea

Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2102)

Deagu, South Korea

Chungnam national university hospital-Department of Internal Medicine ( Site 2107)

Daejeon, South Korea

Kyung Hee University Hospital ( Site 2101)

Seoul, South Korea

Asan Medical Center ( Site 2105)

Seoul, South Korea

Korea University Guro Hospital-Internal Medicine ( Site 2103)

Seoul, South Korea

CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1703)

Santiago de Compostela, Spain

Hospital Insular de Gran Canaria-Oncology ( Site 1701)

Las Palmas de Gran Canaria, Spain

Hospital Quirón Málaga ( Site 1704)

Málaga, Spain

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1700)

Barcelona, Spain

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 1702)

Madrid, Spain

Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1705)

Seville, Spain

National Taiwan University Cancer Center (NTUCC) ( Site 2209)

Taipei City, Taiwan

Taoyuan General Hospital ( Site 2203)

Taoyuan City, Taiwan

Chang Gung Memorial Hospital at Kaohsiung ( Site 2207)

Kaohsiung City, Taiwan

Taichung Veterans General Hospital ( Site 2204)

Taichung, Taiwan

National Cheng Kung University Hospital ( Site 2205)

Tainan, Taiwan

National Taiwan University Hospital-Oncology ( Site 2208)

Taipei, Taiwan

Mackay Memorial Hospital-Chest Medicine ( Site 2201)

Taipei, Taiwan

Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 2202)

Taoyuan, Taiwan

Faculty of Medicine Siriraj Hospital ( Site 2301)

Bangkoknoi, Thailand

Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 2300)

Dusit, Thailand

Prapokklao Hospital ( Site 2306)

Mueang, Thailand

Faculty of Medicine - Khon Kaen University ( Site 2305)

Muang, Thailand

Lampang Cancer Hospital ( Site 2304)

Lampang, Thailand

Songklanagarind hospital ( Site 2303)

Hat Yai, Thailand

Maharaj Nakorn Chiang Mai Hospital ( Site 2302)

Chiang Mai, Thailand

Medipol Mega Universite Hastanesi-oncology ( Site 1811)

Stanbul, Turkey (Türkiye)

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1801)

Ankara, Turkey (Türkiye)

Gazi Universitesi-Oncology ( Site 1804)

Ankara, Turkey (Türkiye)

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1800)

Ankara, Turkey (Türkiye)

Izmir Atatürk Training and Research Hospital ( Site 1810)

Izmir, Turkey (Türkiye)

Memorial Kayseri Hastanesi ( Site 1805)

Kayseri, Turkey (Türkiye)

Mersin Sehir Eğitim ve Araştırma Hastanesi-Oncology ( Site 1808)

Mersin, Turkey (Türkiye)

Samsun Medical Park Hastanesi-medical oncology ( Site 1806)

Samsun, Turkey (Türkiye)

Cleveland Clinic Abu Dhabi ( Site 2650)

Abu Dhabi, United Arab Emirates

Burjeel Medical City ( Site 2600)

Abu Dhabi, United Arab Emirates

North West Cancer Centre ( Site 1908)

Londonderry, United Kingdom

Torbay Hospital ( Site 1906)

Torquay, United Kingdom

St Bartholomew's Hospital ( Site 1901)

London, United Kingdom

City Hospital, Nottingham University Hospitals NHS Trust-NCCTT ( Site 1911)

Nottingham, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.