Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a phase 3 study of pembrolizumab in combination with carboplatin/taxane (paclitaxel or nab-paclitaxel) followed by pembrolizumab with or without maintenance sacituzumab tirumotecan (sac-TMT; MK-2870) in first-line treatment of metastatic squamous non-small cell lung cancer. It is hypothesized that pembrolizumab with maintenance sacituzumab tirumotecan is superior to pembrolizumab without sacituzumab tirumotecan maintenance with respect to overall survival (OS).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak płuca, typ płaskonabłonkowy, w stadium zaawansowanym (przerzuty).
- •Choroba widoczna w badaniach obrazowych.
- •Oczekiwana długość życia pacjenta to co najmniej 3 miesiące.
- •Pacjent jest w dobrym stanie ogólnym (nie jest bardzo osłabiony).
- •Dostępna próbka tkanki guza (z biopsji lub usunięcia).
- •Pacjenci z HIV muszą mieć dobrze kontrolowane zakażenie.
- •Pacjenci z aktywnym zapaleniem wątroby typu B muszą być pod opieką lekarza i mieć niewykrywalną ilość wirusa.
- •Pacjenci, którzy mieli wcześniejsze leczenie przeciwnowotworowe, muszą mieć większość skutków ubocznych wyleczonych lub złagodzonych.
✗ Disqualifies
- •Guzy, które nie są typu płaskonabłonkowego.
- •Choroba nie jest widoczna w badaniach obrazowych.
- •Zbyt krótki przewidywany czas życia pacjenta.
- •Pacjent jest w bardzo złym stanie ogólnym (duże osłabienie).
- •Guzy, które były wcześniej leczone radioterapią.
- •Niekontrolowane zakażenie HIV.
- •Aktywne lub niekontrolowane zakażenie wirusem zapalenia wątroby typu B.
- •Niektóre ciężkie skutki uboczne po wcześniejszych terapiach, które nie ustąpiły.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- June 29, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (212)
CARTI Cancer Center ( Site 0006)
Little Rock, United States
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122)
Burbank, United States
Sharp Memorial Hospital ( Site 9544)
San Diego, United States
Intermountain Health Cancer Center Lutheran Hospital ( Site 0119)
Golden, United States
Intermountain Health St. Mary's Regional Hospital ( Site 0116)
Grand Junction, United States
Washington Hospital Center ( Site 0037)
Washington D.C., United States
Mid Florida Hematology and Oncology Center ( Site 0109)
Orange City, United States
Centricity Research Columbus Cancer Center ( Site 0111)
Columbus, United States
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001)
Marietta, United States
Southeastern Regional Medical Center ( Site 0004)
Newnan, United States
University of Chicago Medical Center ( Site 0145)
Chicago, United States
Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146)
Minneapolis, United States
Capital Health Medical Center - Hopewell ( Site 0034)
Pennington, United States
New Mexico Oncology Hematology Consultants Ltd. ( Site 0123)
Albuquerque, United States
University of New Mexico Comprehensive Cancer Center ( Site 0135)
Albuquerque, United States
St Luke's University Health Network ( Site 0017)
Bethlehem, United States
Thomas Jefferson University - Clinical Research Institute ( Site 0147)
Philadelphia, United States
Memorial Hermann Cancer Center ( Site 0015)
Houston, United States
Oncology Consultants P.A. ( Site 0124)
Houston, United States
Mays Cancer Center ( Site 0132)
San Antonio, United States
Instituto Alexander Fleming ( Site 0203)
Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0200)
Mar del Plata, Argentina
Instituto Médico Río Cuarto ( Site 0204)
Río Cuarto, Argentina
Fundacion Intecnus ( Site 0205)
Bariloche, Argentina
Sanatorio Parque ( Site 0201)
Rosario, Argentina
Hospital Aleman-Oncology ( Site 0202)
Buenos Aires, Argentina
Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0720)
Linz, Austria
Klinik Hietzing ( Site 0740)
Vienna, Austria
Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0730)
Vienna, Austria
Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0710)
Vienna, Austria
Hospital do Cancer de Pernambuco ( Site 0312)
Recife, Brazil
Vencer Centro de Pesquisa Clínica ( Site 0309)
Teresina, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0311)
Porto Alegre, Brazil
Hospital Nossa Senhora da Conceição ( Site 0300)
Porto Alegre, Brazil
Instituto de Oncologia Saint Gallen ( Site 0304)
Santa Cruz do Sul, Brazil
Hospital de Base de São José do Rio Preto ( Site 0310)
São José do Rio Preto, Brazil
Hospital Paulistano ( Site 0307)
São Paulo, Brazil
Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0100)
Kingston, Canada
Waterloo Regional Health Network (WRHN) ( Site 0153)
Kitchener, Canada
St. Marys Hospital Center ( Site 0105)
Montreal, Canada
McGill University Health Centre ( Site 0103)
Montreal, Canada
Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0106)
Trois-Rivières, Canada
Centro de Investigación del Maule ( Site 0419)
Talca, Chile
FALP ( Site 0409)
Santiago, Chile
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0402)
Santiago, Chile
Bradfordhill-Clinical Area ( Site 0407)
Santiago, Chile
ONCOCENTRO APYS-ACEREY ( Site 0400)
Viña del Mar, Chile
Bradford Hill Norte ( Site 0420)
Antofagasta, Chile
Beijing Cancer Hospital ( Site 2411)
Beijing, China
Beijing Cancer hospital-intrathoratic deparmtment II ( Site 2410)
Beijing, China
Peking Union Medical College Hospital ( Site 2412)
Beijing, China
Army Medical Center of People's Liberation Army-respiratory ( Site 2426)
Chongqing, China
Fujian Provincial Cancer Hospital ( Site 2419)
Fuzhou, China
The First Affiliated hospital of Xiamen University-oncology ( Site 2420)
Xiamen, China
The First Affiliated Hospital of Guangzhou Medical University ( Site 2417)
Guangzhou, China
Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 2416)
Guangzhou, China
Harbin Medical University Cancer Hospital-oncology of department ( Site 2415)
Harbin, China
Henan Cancer Hospital-Pneumology department ( Site 2423)
Zhengzhou, China
Tongji Hospital Tongji Medical,Science & Technology ( Site 2424)
Wuhan, China
The Second Xiangya Hospital of Central South University-Oncology ( Site 2418)
Changsha, China
First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 2402)
Huai'an, China
Northern Jiangsu People's Hospital-General Surgery Department ( Site 2403)
Yangzhou, China
The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2405)
Nanchang, China
The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 2404)
Nanchang, China
Jilin Province Tumor Hospital-GCP office ( Site 2413)
Changchun, China
The First Hospital of Jilin University-Oncology ( Site 2414)
Changchun, China
Shanghai East Hospital ( Site 2428)
Shanghai, China
Shanghai Pulmonary Hospital ( Site 2427)
Shanghai, China
West China Hospital, Sichuan University ( Site 2422)
Chengdu, China
Sichuan Cancer hospital. ( Site 2421)
Chengdu, China
The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 2425)
Ürümqi, China
The first Affiliated Hospital, Zhejiang University School of Medicine-Respiratory Department ( Site 2406)
Hangzhou, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 2407)
Hangzhou, China
Zhejiang Cancer Hospital-Breast Oncology ( Site 2408)
Hangzhou, China
Taizhou Hospital of Zhejiang Province ( Site 2430)
Taizhou, China
The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 2409)
Wenzhou, China
Centro Cancerológico del Caribe (CECAC) ( Site 0509)
Barranquilla, Colombia
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0500)
Bogotá, Colombia
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501)
Valledupar, Colombia
Oncologos del Occidente ( Site 0504)
Pereira, Colombia
Fundación Valle del Lili-Oncology CIC ( Site 0505)
Cali, Colombia
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0800)
Brno, Czechia
Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 0803)
Ostrava-Vitkovice, Czechia
Multiscan-Onkologicke a radiologicke centrum Multiscan Pardubice ( Site 0804)
Pardubice, Czechia
Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0802)
Olomouc, Czechia
Clinique Clairval ( Site 0904)
Marseille, France
Hôpital Robert Schuman ( Site 0907)
Vantoux, France
Institut de Cancérologie de l'Ouest ( Site 0908)
Angers, France
Sainte Catherine Institut du Cancer Avignon Provence ( Site 0902)
Avignon, France
CHD Vendee ( Site 0901)
La Roche-sur-Yon, France
Hôpital Saint-Louis ( Site 0906)
Paris, France
GEFOS Gesellschaft f. onkologische Studien ( Site 1005)
Dortmund, Germany
Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 1001)
Essen, Germany
Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 1000)
Lübeck, Germany
SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1006)
Gera, Germany
Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1003)
Berlin, Germany
Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 1100)
Kecskemét, Hungary
Petz Aladar Egyetemi Oktato Korhaz ( Site 1101)
Győr, Hungary
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 1103)
Szolnok, Hungary
Reformatus Pulmonologiai Centrum ( Site 1102)
Törökbálint, Hungary
Zala Megyei Szent Rafael Kórház ( Site 1110)
Zalaegerszeg, Hungary
Országos Korányi Pulmonológiai Intézet ( Site 1104)
Budapest, Hungary
St. James's Hospital ( Site 1200)
Dublin, Ireland
Rambam Health Care Campus-Oncology Division ( Site 1302)
Haifa, Israel
Shaare Zedek Medical Center ( Site 1300)
Jerusalem, Israel
Rabin Medical Center ( Site 1303)
Petah Tikva, Israel
Sheba Medical Center ( Site 1301)
Ramat Gan, Israel
Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1401)
Naples, Italy
Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1409)
Rome, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1404)
Milan, Italy
Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 1412)
Monza, Italy
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1408)
Rozzano, Italy
Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1402)
Rome, Italy
Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1414)
Brescia, Italy
Ospedale San Martino ( Site 1407)
Genova, Italy
Azienda Ospedaliera Maggiore della Carita ( Site 1416)
Novara, Italy
Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 1410)
Pavia, Italy
Ospedale di Circolo e Fondazione Macchi Varese-Oncology ( Site 1413)
Varese, Italy
Centro Ricerche Cliniche di Verona s.r.l. c/o Policlinico G.B.Rossi ( Site 1415)
Verona, Italy
Aichi Cancer Center ( Site 2502)
Nagoya, Japan
Nagoya University Hospital ( Site 2519)
Nagoya, Japan
Fujita Health University Hospital ( Site 2515)
Toyoake, Japan
Hirosaki University Hospital ( Site 2514)
Hirosaki, Japan
National Cancer Center Hospital East ( Site 2501)
Kashiwa, Japan
Ehime University Hospital ( Site 2511)
Tōon, Japan
Gunma Prefectural Cancer Center ( Site 2510)
Ōta, Japan
Kobe Minimally Invasive Cancer Center ( Site 2528)
Kobe, Japan
Takarazuka City Hospital ( Site 2508)
Takarazuka, Japan
Kanazawa University Hospital ( Site 2513)
Kanazawa, Japan
St. Marianna University Hospital ( Site 2521)
Kawasaki, Japan
Kanagawa Cardiovascular and Respiratory Center ( Site 2518)
Yokohama, Japan
Kanagawa Cancer Center ( Site 2504)
Yokohama, Japan
Kochi Medical School Hospital ( Site 2526)
Nankoku, Japan
Saiseikai Matsusaka Municipal Hospital ( Site 2522)
Matsusaka, Japan
Tohoku University Hospital ( Site 2525)
Sendai, Japan
Sendai Kousei Hospital ( Site 2507)
Sendai, Japan
Kansai Medical University Hospital ( Site 2503)
Hirakata, Japan
National Hospital Organization Ureshino Medical Center ( Site 2524)
Ureshino, Japan
Saitama Prefectural Cancer Center ( Site 2512)
Kitaadachi-gun, Japan
Cancer Institute Hospital of JFCR ( Site 2500)
Koto, Japan
Toho University Omori Medical Center ( Site 2520)
Ōta-ku, Japan
National Center for Global Health and Medicine ( Site 2516)
Shinjuku, Japan
National Hospital Organization Yamaguchi Ube Medical Center ( Site 2523)
Ube, Japan
Chiba University Hospital ( Site 2517)
Chiba, Japan
National Hospital Organization Kyushu Medical Center ( Site 2509)
Fukuoka, Japan
Niigata Cancer Center Hospital ( Site 2505)
Niigata, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2506)
Osaka, Japan
Clínica San Antonio ( Site 0606)
Trujillo, Peru
Clínicas AUNA Sede Chiclayo ( Site 0604)
Chiclayo, Peru
Oncosalud-Clinical Research ( Site 0600)
Lima, Peru
Hospital Militar Central Coronel Luis Arias Schereiber ( Site 0602)
Lima, Peru
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1503)
Bydgoszcz, Poland
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1513)
Grudziądz, Poland
Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1507)
Gorlice, Poland
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1515)
Krakow, Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 1510)
Poznań, Poland
Instytut Gruzlicy i Chorob Pluc w Warszawie ( Site 1523)
Warsaw, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1500)
Warsaw, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1501)
Przemyśl, Poland
Bialostockie Centrum Onkologii ( Site 1520)
Bialystok, Poland
Szpital Wojewódzki w Koszalinie. ( Site 1517)
Poland, Poland
Centrul Medical Medicover Victoria ( Site 2000)
Bucharest, Romania
Cardiomed SRL Cluj-Napoca ( Site 2002)
Cluj-Napoca, Romania
SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2001)
Florești, Romania
Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2004)
Craiova, Romania
Cabinet Medical Oncomed ( Site 2005)
Timișoara, Romania
SC ONCO CARD SRL ( Site 2007)
Brasov, Romania
Lotus-Med ( Site 2009)
Bucharest, Romania
Clinica Polisano ( Site 2008)
Sibiu, Romania
The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 2106)
Bupyeong-gu, South Korea
Pusan National University Yangsan Hospital ( Site 2104)
Yangsan, South Korea
Pusan National University Hospital ( Site 2100)
Busan, South Korea
Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2102)
Deagu, South Korea
Chungnam national university hospital-Department of Internal Medicine ( Site 2107)
Daejeon, South Korea
Kyung Hee University Hospital ( Site 2101)
Seoul, South Korea
Asan Medical Center ( Site 2105)
Seoul, South Korea
Korea University Guro Hospital-Internal Medicine ( Site 2103)
Seoul, South Korea
CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1703)
Santiago de Compostela, Spain
Hospital Insular de Gran Canaria-Oncology ( Site 1701)
Las Palmas de Gran Canaria, Spain
Hospital Quirón Málaga ( Site 1704)
Málaga, Spain
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1700)
Barcelona, Spain
Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 1702)
Madrid, Spain
Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1705)
Seville, Spain
National Taiwan University Cancer Center (NTUCC) ( Site 2209)
Taipei City, Taiwan
Taoyuan General Hospital ( Site 2203)
Taoyuan City, Taiwan
Chang Gung Memorial Hospital at Kaohsiung ( Site 2207)
Kaohsiung City, Taiwan
Taichung Veterans General Hospital ( Site 2204)
Taichung, Taiwan
National Cheng Kung University Hospital ( Site 2205)
Tainan, Taiwan
National Taiwan University Hospital-Oncology ( Site 2208)
Taipei, Taiwan
Mackay Memorial Hospital-Chest Medicine ( Site 2201)
Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 2202)
Taoyuan, Taiwan
Faculty of Medicine Siriraj Hospital ( Site 2301)
Bangkoknoi, Thailand
Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 2300)
Dusit, Thailand
Prapokklao Hospital ( Site 2306)
Mueang, Thailand
Faculty of Medicine - Khon Kaen University ( Site 2305)
Muang, Thailand
Lampang Cancer Hospital ( Site 2304)
Lampang, Thailand
Songklanagarind hospital ( Site 2303)
Hat Yai, Thailand
Maharaj Nakorn Chiang Mai Hospital ( Site 2302)
Chiang Mai, Thailand
Medipol Mega Universite Hastanesi-oncology ( Site 1811)
Stanbul, Turkey (Türkiye)
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1801)
Ankara, Turkey (Türkiye)
Gazi Universitesi-Oncology ( Site 1804)
Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1800)
Ankara, Turkey (Türkiye)
Izmir Atatürk Training and Research Hospital ( Site 1810)
Izmir, Turkey (Türkiye)
Memorial Kayseri Hastanesi ( Site 1805)
Kayseri, Turkey (Türkiye)
Mersin Sehir Eğitim ve Araştırma Hastanesi-Oncology ( Site 1808)
Mersin, Turkey (Türkiye)
Samsun Medical Park Hastanesi-medical oncology ( Site 1806)
Samsun, Turkey (Türkiye)
Cleveland Clinic Abu Dhabi ( Site 2650)
Abu Dhabi, United Arab Emirates
Burjeel Medical City ( Site 2600)
Abu Dhabi, United Arab Emirates
North West Cancer Centre ( Site 1908)
Londonderry, United Kingdom
Torbay Hospital ( Site 1906)
Torquay, United Kingdom
St Bartholomew's Hospital ( Site 1901)
London, United Kingdom
City Hospital, Nottingham University Hospitals NHS Trust-NCCTT ( Site 1911)
Nottingham, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.