a Single-arm, Single-center, Open Clinical Study
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This trial plans to enroll many patients with advanced solid tumors to complete GK01 cell transfusion, including but not limited to advanced gastric cancer, esophageal cancer, cervical cancer, triple-negative breast cancer, and non-small cell lung cancer. For patients with advanced solid tumors eligible for inclusion, autologous tumor-reactive T cells (experimental drug GK01) were cultured and prepared, and a certain dose of GK01 cells was given according to the cell transfusion plan, and the safety and tolerability of the patients after transfusion were observed. Exploratory evaluation of pharmacokinetic/pharmacodynamic profiles following reinfusion and initial evaluation of efficacy of investigational drug GK01 cells according to RECIST 1.1 criteria.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek od 18 do 75 lat, mężczyzna lub kobieta
- •Zaawansowany nieuleczalny nowotwór (żołądka, przełyku, szyjki macicy, piersi, płuc lub inny), który nie reaguje na standardowe leczenie
- •Dostępna próbka tkanki nowotworowej lub płynu z jamy brzusznej/opłucnej do badania (co najmniej 0,5 cm³ tkanki lub 0,5 g wagi, albo minimum 5×10⁸ komórek w płynie)
- •Obecność co najmniej jednego mierzalnego ogniska nowotworu po pobraniu próbki
- •Ogólny stan zdrowia pozwalający na aktywność (ECOG 0-1)
- •Spodziewana długość życia ponad 3 miesiące
- •Prawidłowe wyniki badań krwi, nerek, wątroby i serca (zgodnie ze szczegółowymi normami)
- •Kobiety w wieku rozrodczym: negatywny test ciążowy i zgoda na skuteczną antykoncepcję przez co najmniej rok
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- May 28, 2024
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Trial contact
Yi Zhang, Doctor
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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