NEODOXy: Targeting Breast Cancer Stem Cells With Doxycycline
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Despite modern surgical and medical treatments, breast cancer can re-occur and lead 20% of patients to death. During the last 20 years, pre-clinical studies have shown that treatment failures may be due to the presence of a sub-type of cancer cells, the cancer stem cells, which are resistant to chemotherapy and radiotherapy. By chance, doxycycline, an old, inexpensive and safe molecule seems to target effectively these cancer stem cells. This study proposes to check for the clinical efficacy of doxycycline to target the cancer stem cells and improve the response to neoadjuvant chemotherapy in ER+/HER2- breast cancers.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dobrowolna, pisemna zgoda na uczestnictwo w badaniu
- •Potwierdzony histologicznie nowotwór piersi ER-dodatni i HER2-ujemny
- •Guz co najmniej 2 cm, kwalifikujący się do operacji ratującej vida
- •Pacjent planuje chemioterapię przedoperacyjną według lokalnych standardów
- •Pacjent zgadza się na standardową operację po chemioterapii (4 cykle EC + 12 dawek paclitaxelu)
- •Dostępna próbka tkanki guza do badań lub planowana dodatkowa biopsja
- •Wiek co najmniej 18 lat
- •Prawidłowe funkcje wątroby, nerek i szpiku kostnego
✗ Disqualifies
- •Dwa lub więcej nowotworów piersi o różnych typach
- •Pacjent z przerzutami raka
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- December 30, 2025
- Sex
- No restrictions
Therapies / drugs in trial
Locations (8)
Kantonsspital St.Gallen
Sankt Gallen, Switzerland
Clinique de Genolier
Genolier, Switzerland
Kantonsspital Winterthur
Winterthur, Switzerland
Kantonsspital Graubünden
Chur, Switzerland
Tumor Zentrum Aarau
Aarau, Switzerland
Réseau du sein Lausanne
Lausanne, Switzerland
Centre Hospitalier Universitaire Vaudois (CHUV)
Lausanne, Switzerland
Tumor- und Brustzentrum Ostschweiz
Sankt Gallen, Switzerland
Trial contact
Daniela Zoelly, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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