Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less than a quarter of patients with lung metastases will achieve a complete response to RAI therapy, and this therapy carries the risk of pulmonary fibrosis and an increasingly recognized risk of secondary malignancies.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 2-25 lat
- •Potwierdzony histologicznie rak tarczycy, po operacji usunięcia tarczycy i leczeniu przerzutów w szyi
- •Widoczne przerzuty w płucach (ponad 10 guzków lub powiększające się guzki) na tomografii komputerowej
- •Potwierdzona mutacja genu RET (zmiana genetyczna) w badaniu laboratoryjnym
- •Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu (powyżej 50%)
- •Prawidłowe funkcjonowanie szpiku kostnego (wystarczająca liczba krwinek)
- •Prawidłowe funkcjonowanie nerek i wątroby
- •Prawidłowe poziomy potasu, wapnia i magnezu we krwi
Simplified criteria — AI translation
Trial details
- Minimum age
- 2 Years
- Maximum age
- 25 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (5)
The Unviersity of California, San Francisco (UCSF)
San Francisco, United States
Children's Hospital of Philadelphia
Philadelphia, United States
St. Jude Children's Research Hospital
Memphis, United States
MD Anderson Cancer Center
Houston, United States
Seattle Children's Hospital
Seattle, United States
Trial contact
Meghan Donnelly, MPH
James Robinson
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.
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