RecruitingPhase IIEN original

A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This study will enroll adult participants with early-stage (stage II-IIIB) non-small cell lung cancer for whom surgery is planned. The aim is to find out whether an investigational treatment (consisting of the immunotherapy drug cemiplimab plus chemotherapy plus a third drug) works better than cemiplimab plus chemotherapy without the additional drug. The study is also looking at several other research questions, including: * What are the side effects associated with the investigational treatments in comparison to the control treatment? * Do the investigational treatments or the control treatment have an effect on the type of surgery that is performed? * How much of the study drug(s) are in the blood at a given time? * Does the body make antibodies against the study drug(s) (which could make the drug(s) less effective or could lead to side effects)?

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony rozpoznaniem histologicznym rak płuca NSCLC etapu II-IIIB, który można operacyjnie usunąć
  • Widoczne zmiany nowotworowe wykrywalne w badaniach obrazowych
  • Dostępne próbki tkanki guza do badań laboratoryjnych
  • Ogólny stan zdrowia pozwalający na uczestnictwo w badaniu (skala ECOG 0-1)
  • Prawidłowa funkcja narządów wewnętrznych i szpiku kostnego

✗ Disqualifies

  • Wcześniejsze chemioterapie lub napromienianie tego guza
  • Obecność określonych zmian genetycznych w guzie (EGFR lub ALK)
  • Poważne uszkodzenie nerwów (grade ≥2)
  • Inny nowotwór wymagający aktywnego leczenia
  • Bardzo wysokie stężenie wapnia we krwi
  • Problemy neurologiczne mogące zwiększać ryzyko powikłań immunologicznych
  • Zaburzenia rytmu serca (wydłużony odstęp QT) lub ryzyko ich występowania

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 8, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (50)

University of California Irvine

Orange, United States

Orchard Healthcare Research Inc.

Skokie, United States

Karmanos Cancer Institute

Detroit, United States

Detroit Clinical Research Center

Farmington Hills, United States

Morristown Medical Center

Morristown, United States

Rutgers Cancer Institute of New Jersey

New Brunswick, United States

Oncology Hematology Care Clinical Trials LLC

Cincinnati, United States

Providence Portland Medical Center

Portland, United States

University Of Nebraska Medical Center

Portland, United States

Lifespan Cancer Institute

Providence, United States

Prairie Lakes Healthcare System

Watertown, United States

University of Tennessee Medical Center

Knoxville, United States

Sarah Cannon Research Institute (SCRI) Oncology Partners

Nashville, United States

Tennessee Oncology

Nashville, United States

BRCC/Oncology & Hematology Associates of SW Virginia

Blacksburg, United States

Oncology Clinical Research Center

Cachoeiro de Itapemirim, Brazil

Instituto Mario Penna

Belo Horizonte, Brazil

Instituto Sul Mineiro De Oncologia LTDA

Pouso Alegre, Brazil

Instituto de Medicina Integral Professor Fernando Figueira

Recife, Brazil

Liga Norte Riograndense Contra o Cancer

Natal, Brazil

Hospital Mae de Deus Integrated Oncology Center

Porto Alegre, Brazil

Hospital Sao Lucas da PUCRS

Porto Alegre, Brazil

Ynova Pesquisa Clinica

Florianópolis, Brazil

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

São José do Rio Preto, Brazil

Unimed Sorocaba

Sorocaba, Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, Brazil

CHU Rennes

Rennes, France

Centre Hospitalier Intercommunal Toulon - CHITS

Toulon, France

Centre Hospitalier de la Cote Basque

Bayonne, France

Clinique Belharra

Bayonne, France

CHU Grenoble Alpes

Grenoble, France

Montpellier Academic Hospital

Montpellier, France

Institut Curie

Paris, France

Klinikum Kassel GmbH, Hauttumorzentrum

Kassel, Germany

University Medicine Gottingen

Göttingen, Germany

University of Leipzig

Leipzig, Germany

University Hospital RWTH Aachen

Aachen, Germany

Catalan Instituye of Oncology Badalona

Badalona, Spain

Hospital Valdecilla

Santander, Spain

Hospital Universitario Insular de Gran Canaria

Las Palmas de Gran Canaria, Spain

Clinica Universidad de Navarra

Pamplona, Spain

MD Anderson Cancer Center

Madrid, Spain

Hospital Universitario Clinico San Carlos

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital Universitario HM Sanchinarro

Madrid, Spain

Hospital Virgen del Rocio

Seville, Spain

Hospital Clinico Universitario Valencia

Valencia, Spain

Consorci Hospital General Universitario de Valencia

Valencia, Spain

Hospital Clinico Lozano Blesa

Zaragoza, Spain

Florya Medical Park Hospital

Istanbul, Turkey (Türkiye)

Trial contact

Clinical Trials Administrator

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.

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