Tumor-microenvironment Spatial Interaction to Identify Markers of Resistance to Therapy in HER2+ Breast Cancer Patients
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This retrospective observational study aims at the comparison of the tumour-microenvironment tissue architecture before and after neo-adjuvant therapy in samples from HER2-positive (HER2+) breast cancer (BrCa) patients that display residual invasive disease in the breast/lymph node at surgery after standard-of-care combined chemotherapy and trastuzumab treatment. The working hypothesis of the investigators is that: Therapy imposes a selective pressure on tumour-microenvironment features promoting resistance to treatment. Participant that have already undergone neo-adjuvant treatment as part of their regular medical care for HER2-positive breast cancer will provide access to formalin-fixed paraffin-embedded (FFPE) samples taken before and after therapy. Tumoral, peri-tumoral and stromal regions of each specimen will be analyzed with the ultimate goal to identify new biomarkers (and putative targets) of resistance to therapy.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Uczestnik wyraża dobrowolną zgodę na udział w badaniu
- •Pacjent przed operacją przeszedł biopsję i chemioterapię (leki przeciwnowotworowe, potem leki na bazie taksanów) wraz z lekiem Herceptin
- •Próbka z operacji wykazuje resztkową chorobę nowotworową w piersi lub węzłach chłonnych
✗ Disqualifies
- •Poważne schorzenia lub inne choroby współistniejące
- •Jednoczesne stosowanie innych leków podczas chemioterapii wstępnej
- •Złej jakości próbka do badania analitycznego
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- April 15, 2026
- Sex
- Female only
Locations (1)
IRCCS San Raffaele Hospital
Milan, Italy
Trial contact
Tiziana Daniele, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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