RecruitingPhase IIEN originalLymphoma

Surovatamig (AZD0486) as Monotherapy in Participants With Relapsed/Refractory (R/R) B-cell NHL

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a Phase 2 global, multi-center, open-label study to assess the efficacy, safety and tolerability of surovatamig (AZD0486) monotherapy in adult participants with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) who have received at least two prior lines of therapies. The study has 2 Modules: Module 1 for FL and Module 2 for LBCL.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek 18 lat i więcej
  • Potwierdzona histologicznie nawrotowa lub oporna na leczenie choroba (po co najmniej 2 poprzednich leczeniach)
  • Dobry stan ogólny (ECOG 0-2)
  • Wykrycie białka CD-19 na komórkach chłoniaka
  • Widoczna choroba w badaniach obrazowych (guzy węzłów lub innych narządów o określonych rozmiarach)
  • Prawidłowa liczba krwinek białych, płytek krwi i hemoglobiny
  • Prawidłowa funkcja wątroby i nerek
  • Prawidłowa funkcja serca (wyfrancja lewej komory ≥45%)

✗ Disqualifies

  • Rozpoznanie białaczki limfocytowej, chłoniaka Burkitta lub transformacji Richtera
  • Zaangażowanie ośrodkowego układu nerwowego (mózgu lub rdzenia kręgowego)
  • Chłoniak w postaci białaczki (komórki w krwi obwodowej)
  • Historia problemów neurologicznych wymagających leczenia w ostatnim roku (epilepsja, udar, demencja, poważne zaburzenia psychiczne)
  • Leczenie innymi terapiami celowanymi w ciągu 6-12 tygodni przed badaniem (terapie CAR-T, przeszczep szpiku)
  • Aktywna infekcja lub inne poważne schorzenia utrudniające udział w badaniu

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 13, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (94)

Research Site

Phoenix, United States

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Duarte, United States

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Jacksonville, United States

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Tampa, United States

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Chicago, United States

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Iowa City, United States

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Waukee, United States

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Overland Park, United States

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Rochester, United States

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St Louis, United States

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New Brunswick, United States

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New York, United States

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Charlotte, United States

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Columbus, United States

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Portland, United States

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Philadelphia, United States

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Pittsburgh, United States

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Pittsburgh, United States

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Nashville, United States

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Austin, United States

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Houston, United States

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San Antonio, United States

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Milwaukee, United States

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Heidelberg, Australia

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Kogarah, Australia

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Macquarie University, Australia

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Nedlands, Australia

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Porto Alegre, Brazil

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São Paulo, Brazil

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São Paulo, Brazil

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Barrie, Canada

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Brampton, Canada

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Ottawa, Canada

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Toronto, Canada

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Chengdu, China

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Chengdu, China

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Guangzhou, China

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Nanchang, China

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Nanjing, China

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Nantong, China

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Shandong, China

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Shanghai, China

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Shanghai, China

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Tianjin, China

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Zhengzhou, China

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Aalborg, Denmark

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Copenhagen, Denmark

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Vejle, Denmark

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Montpellier, France

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Paris, France

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Pierre-Bénite, France

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Rouen, France

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Berlin, Germany

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Chemnitz, Germany

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Essen, Germany

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Jena, Germany

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Würzburg, Germany

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Hong Kong, Hong Kong

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Shatin, Hong Kong

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Alessandria, Italy

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Bologna, Italy

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Busto Arsizio, Italy

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Milan, Italy

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Milan, Italy

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Roma, Italy

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Chiba, Japan

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Kashiwa, Japan

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Kōtoku, Japan

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Kumamoto, Japan

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Niigata, Japan

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Okayama, Japan

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Osaka, Japan

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Yokohama, Japan

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Barcelona, Spain

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Madrid, Spain

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Pozuelo de Alarcón, Spain

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Gothenburg, Sweden

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Stockholm, Sweden

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Kaohsiung City, Taiwan

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Kaohsiung City, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Tainan, Taiwan

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Taipei, Taiwan

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London, United Kingdom

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Manchester, United Kingdom

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Norwich, United Kingdom

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Nottingham, United Kingdom

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Plymouth, United Kingdom

Trial contact

AstraZeneca Clinical Study Information Center

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/14/2026.

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