A Study of MOv18 IgE in Patients With Solid Tumours That Express Folate Receptor Alpha
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
EPS101-10-02 is a Phase Ib open label, multicentre clinical trial comprising of a Dose Escalation phase (Part 1) followed by a Dose Expansion phase (Part 2) of MOv18 IgE in patients with folate receptor alpha-expressing (5% or higher) platinum resistant ovarian cancer The dose escalation part of the study will primarily assess the safety and tolerability of MOv18 IgE in ascending dose cohorts, until the determination of the maximum tolerated dose (MTD) or maximum administered dose (MAD). Part 2 (dose expansion) will further assess the safety, tolerability and anti-tumour activity of MOv18 IgE.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Kobieta w wieku co najmniej 18 lat
- •Pisemna, podpisana i datowana zgoda na uczestnictwo w badaniu
- •Potwierdzony rozpoznaniem zaawansowany, nawracający lub przerzutowy rak jajnika, macicy lub piersi (trojca ujemny)
- •Komórki nowotworu wykazują białko FRα na co najmniej 5% células, potwierdzone badaniem immunohistochemicznym
- •Ujemny test aktywacji bazofilów przed rozpoczęciem leczenia
- •Dla raka jajnika: ostatnia chemioterapia platynową zakończyła się mniej niż 6 miesięcy temu
- •Wcześniejsze leczenie przeciwnowotworowe: maksymalnie 2 wcześniejsze rodzaje chemioterapii, bez dostępnych alternatywnych zatwierdzonych leków
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- April 6, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (7)
Bristol Haematology and Oncology Centre
Bristol, United Kingdom
Edinburgh Cancer Research Centre
Edinburgh, United Kingdom
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Cambridge University - Addenbrooke's Hospital
London, United Kingdom
University College London Hospital
London, United Kingdom
Guy's Hospital
London, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom
Trial contact
Epsilogen Clinical Trials
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.
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