A Study of Vemurafenib and Obinutuzumab Compared to Cladribine and Rituximab in People With Hairy Cell Leukemia (HCL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The researchers are doing this study to compare the safety of vemurafenib in combination with obinutuzumab to the standard of approach of cladribine in combination with rituximab. The researchers will look at which treatment causes fewer or milder side effects. Researchers think vemurafenib and obinutuzumab (non-chemotherapy drugs) may cause fewer side effects compared with the usual approach of chemotherapy drugs. They will also compare the two approaches to see which approach is more effective at eliminating cancer cells.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzona białaczka włochatokomórkowa
- •Obecna mutacja BRAF V600E w komórkach nowotworowych
- •Nigdy wcześniej nie leczony pacjent
- •Pacjent spełniający kryteria do rozpoczęcia leczenia (obniżona liczba białych ciałek, hemoglobiny lub płytek krwi)
- •Dobre ogólne samopoczucie (ECOG 0-2)
- •Prawidłowo funkcjonujące wątroba i nerki (badania krwi)
- •Prawidłowe badanie serca (EKG)
✗ Disqualifies
- •Wcześniejsze leczenie białaczki włochatokomórkowej jakimikolwiek lekami
- •Przygotowywanie się do zajścia w ciążę lub planowanie ciąży (ze względu na toksyczność leków)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Dana Farber Cancer Institute
Boston, United States
Mayo Clinic Cancer Center
Rochester, United States
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)
Basking Ridge, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, United States
Memorial Sloan Kettering Cancer Commack - Suffolk (Limited Protocol Activities)
Commack, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, United States
Ohio State University
Columbus, United States
Trial contact
Jae Park, MD
Mark Geyer, MD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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