RecruitingPhase IIIEN original

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This study will test a study drug called cemiplimab to see if it can help treat early-stage Cutaneous Squamous Cell Carcinoma (CSCC), a type of skin cancer. Cemiplimab works by helping the immune system to kill cancer cells. It binds to a protein called Programmed cell Death-1 (PD-1) on the surface of certain immune cells. The main purpose of this study is to compare how well cemiplimab works compared to surgery, when injected into the lesion. The study is looking at: * The side effects cemiplimab might cause * How well cemiplimab works compared to surgery

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony laboratoryjnie rak kolczystokomórkowy skóry.
  • Zmiana skórna o wielkości od 1 do 2 cm, zlokalizowana na głowie, szyi, dłoni lub przedniej części podudzia.
  • Pacjent kwalifikuje się do leczenia chirurgicznego, które obejmuje kontrolę marginesów (np. operacja Mohsa).
  • Ogólny stan zdrowia pacjenta dobry (niezależny w codziennych czynnościach).

✗ Disqualifies

  • Zmiana skórna innego typu (np. rak podstawnokomórkowy, rak in situ bez komponentu inwazyjnego) lub jeśli jest to keratoakantoma.
  • Występowanie w ciągu ostatnich 5 lat poważnych chorób autoimmunologicznych leczonych lekami osłabiającymi odporność.
  • Występowanie w ciągu ostatnich 5 lat zapalenia płuc niezwiązanego z infekcją.
  • Zmiana skórna zlokalizowana na czerwieni wargowej, w jamie ustnej lub na błonie śluzowej nosa.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
June 30, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (52)

Medical Dermatology Specialists - Phoenix

Phoenix, United States

Mayo Clinic - Arizona

Scottsdale, United States

University of Arizona Cancer Center

Tucson, United States

Arkansas Research Trials

North Little Rock, United States

UC San Diego Moores Cancer Center

La Jolla, United States

Profound Research, Dermatology Medical Group - Oceanside

Oceanside, United States

Stanford University

Redwood City, United States

Peak Dermatology, Aesthetics and Wellness

Visalia, United States

George Washington University Medical Faculty Associates

Washington D.C., United States

Life Clinical Trials

Coral Springs, United States

Dermatology Associates of the Palm Beaches, Integri Research at Dermatology Associates

Delray Beach, United States

University of South Florida

Tampa, United States

University of Chicago Medical Center

Chicago, United States

Oak Dermatology

Naperville, United States

Dawes Fretzin Clinical Research - Shadeland Ave.

Indianapolis, United States

Equity Medical, LLC

Bowling Green, United States

US Dermatology Partners DBA DermAssociates, PC

Rockville, United States

Northeast Dermatology Associates

Beverly, United States

Dana-Farber Cancer Institute

Boston, United States

MyMichigan Dermatologic Oncology

Midland, United States

Somerset Skin Centre

Troy, United States

Dermatology and Skin Cancer Center

Lee's Summit, United States

Washington University in St. Louis - Center for Dermatologic and Cosmetic Surgery

St Louis, United States

Las Vegas Dermatology

Las Vegas, United States

StracSkin, PLLC

Portsmouth, United States

Metropolitan Dermatology

Clark, United States

University of New Mexico

Albuquerque, United States

Memorial Sloan Kettering Cancer Center

New York, United States

Columbia University Medical Center - Herbert Irving Center for Dermatology and Skin Cancer - Herbert Irving Pavilion

New York, United States

Rochester Dermatologic Surgery, P.C.

Victor, United States

UNC Hospitals Dermatology and Skin Cancer Center at Southern Village

Chapel Hill, United States

Cleveland Clinic

Cleveland, United States

Buckeye Dermatology - Springfield Office

Springfield, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Dermatology Health Specialists

Bend, United States

Oregon Health & Science University

Portland, United States

Penn State Hershey Medical Center

Hershey, United States

Hospital of the University of Pennsylvania

Philadelphia, United States

Clinical Research Center of the Carolinas

Charleston, United States

The University of Texas at Austin Dell Medical School Ascension Medical Group

Austin, United States

Reveal Research Institute

Dallas, United States

The University of Texas MD Anderson Cancer Center

Houston, United States

Epiphany Dermatology

Lewisville, United States

Texas Dermatology and Laser Specialists

San Antonio, United States

Center for Clinical Studies at Webster Clear Lake

Webster, United States

University of Utah Hospital

Salt Lake City, United States

Vcu Massey Cancer Center

Richmond, United States

The Skin Hospital

Darlinghurst, Australia

Westmead Hospital

Westmead, Australia

Princess Alexandra Hospital

Woolloongabba, Australia

Dermatology Institute of Victoria (DIV)

South Yarra, Australia

Fremantle Dermatology

Fremantle, Australia

Trial contact

Clinical Trials Administrator

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.