RecruitingPhase IIIEN original

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back after a period of improvement (recurrent) and/or that has spread from where it first started (primary site) to other places in the body (metastatic). Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of tumor cells. This may help keep tumor cells from growing. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the tumor, and may interfere with the ability of tumor cells to grow and spread. Giving cetuximab and pembrolizumab together may be more effective at treating patients with recurrent and/or metastatic HNSCC than pembrolizumab alone.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzona biopsją diagnoza raka płaskonabłonkowego głowy i szyi
  • Rak pierwotnie umiejscowiony w jamie ustnej, gardle, krtani lub gardła dolnego
  • Choroba powróciła po leczeniu lub rozszerzyła się na inne części ciała, ale nie była dotychczas leczona w tym stadium
  • Poddano poprzednio chemioterapii i radioterapii (bez odpowiedzi na leczenie lub choroba wróciła w ciągu 29 tygodni)
  • Tumor wykazuje dodatni wynik testu PD-L1
  • Wymierny nowotwór widoczny w badaniach obrazowych
  • Radioterapia zakończona co najmniej 10 dni przed włączeniem do badania
  • Brak wcześniejszego leczenia w stadium zaawansowanym

✗ Disqualifies

  • Uczulenie na pembrolizumab lub cetuximab
  • Szczepienie żywą szczepionką w ciągu ostatnich 30 dni
  • Stosowanie wysokich dawek sterydów lub leków osłabiających odporność w ciągu 7 dni przed badaniem
  • Rak garła dodatni na HPV (wirus zakaźny)
  • Choroba postępowała podczas poprzedniego leczenia immunoterapią lub cetuximabem (jeśli było mniej niż 26 tygodni temu)

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 24, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (192)

University of Arkansas for Medical Sciences

Little Rock, United States

Fremont - Rideout Cancer Center

Marysville, United States

VA Palo Alto Health Care System

Palo Alto, United States

UCHealth Memorial Hospital Central

Colorado Springs, United States

Memorial Hospital North

Colorado Springs, United States

Poudre Valley Hospital

Fort Collins, United States

Cancer Care and Hematology-Fort Collins

Fort Collins, United States

Lutheran Hospital - Cancer Centers of Colorado

Golden, United States

UCHealth Greeley Hospital

Greeley, United States

Medical Center of the Rockies

Loveland, United States

Mount Sinai Medical Center

Miami Beach, United States

Saint Alphonsus Cancer Care Center-Boise

Boise, United States

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, United States

Kootenai Health - Coeur d'Alene

Coeur d'Alene, United States

Saint Alphonsus Cancer Care Center-Nampa

Nampa, United States

Kootenai Clinic Cancer Services - Post Falls

Post Falls, United States

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, United States

Advocate Good Shepherd Hospital

Barrington, United States

University of Chicago Comprehensive Cancer Center

Chicago, United States

Advocate Illinois Masonic Medical Center

Chicago, United States

AMG Crystal Lake - Oncology

Crystal Lake, United States

Cancer Care Specialists of Illinois - Decatur

Decatur, United States

Decatur Memorial Hospital

Decatur, United States

Advocate Good Samaritan Hospital

Downers Grove, United States

Crossroads Cancer Center

Effingham, United States

Advocate Sherman Hospital

Elgin, United States

Advocate South Suburban Hospital

Hazel Crest, United States

AMG Libertyville - Oncology

Libertyville, United States

Condell Memorial Hospital

Libertyville, United States

Illinois CancerCare-Macomb

Macomb, United States

UC Comprehensive Cancer Center at Silver Cross

New Lenox, United States

Cancer Care Center of O'Fallon

O'Fallon, United States

Advocate Christ Medical Center

Oak Lawn, United States

Advocate Outpatient Center - Oak Lawn

Oak Lawn, United States

University of Chicago Medicine-Orland Park

Orland Park, United States

Advocate High Tech Medical Park

Palos Heights, United States

Advocate Lutheran General Hospital

Park Ridge, United States

Illinois CancerCare-Peoria

Peoria, United States

UW Health Carbone Cancer Center Rockford

Rockford, United States

Memorial Hospital East

Shiloh, United States

Southern Illinois University School of Medicine

Springfield, United States

Springfield Clinic

Springfield, United States

Springfield Memorial Hospital

Springfield, United States

UChicago Medicine Northwest Indiana

Crown Point, United States

Mary Greeley Medical Center

Ames, United States

McFarland Clinic - Ames

Ames, United States

McFarland Clinic - Boone

Boone, United States

Mercy Hospital

Cedar Rapids, United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, United States

McFarland Clinic - Trinity Cancer Center

Fort Dodge, United States

McFarland Clinic - Jefferson

Jefferson, United States

McFarland Clinic - Marshalltown

Marshalltown, United States

HaysMed

Hays, United States

University of Kansas Cancer Center

Kansas City, United States

Lawrence Memorial Hospital

Lawrence, United States

The University of Kansas Cancer Center - Olathe

Olathe, United States

University of Kansas Cancer Center-Overland Park

Overland Park, United States

University of Kansas Hospital-Indian Creek Campus

Overland Park, United States

Salina Regional Health Center

Salina, United States

University of Kansas Health System Saint Francis Campus

Topeka, United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, United States

University of Maryland/Greenebaum Cancer Center

Baltimore, United States

Boston Medical Center

Boston, United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, United States

Cancer Hematology Centers - Flint

Flint, United States

Genesee Hematology Oncology PC

Flint, United States

Genesys Hurley Cancer Institute

Flint, United States

Hurley Medical Center

Flint, United States

University of Michigan Health - Sparrow Lansing

Lansing, United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, United States

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, United States

Sanford Joe Lueken Cancer Center

Bemidji, United States

Minnesota Oncology - Burnsville

Burnsville, United States

Mercy Hospital

Coon Rapids, United States

Fairview Southdale Hospital

Edina, United States

Saint John's Hospital - Healtheast

Maplewood, United States

Abbott-Northwestern Hospital

Minneapolis, United States

Hennepin County Medical Center

Minneapolis, United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, United States

Regions Hospital

Saint Paul, United States

United Hospital

Saint Paul, United States

Saint Francis Medical Center

Cape Girardeau, United States

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, United States

Siteman Cancer Center at West County Hospital

Creve Coeur, United States

University Health Truman Medical Center

Kansas City, United States

University of Kansas Cancer Center - Briarcliff

Kansas City, United States

University of Kansas Cancer Center - North

Kansas City, United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, United States

Lake Regional Hospital

Osage Beach, United States

Washington University School of Medicine

St Louis, United States

Mercy Hospital South

St Louis, United States

Siteman Cancer Center-South County

St Louis, United States

Siteman Cancer Center at Christian Hospital

St Louis, United States

Community Hospital of Anaconda

Anaconda, United States

Billings Clinic Cancer Center

Billings, United States

Bozeman Health Deaconess Hospital

Bozeman, United States

Benefis Sletten Cancer Institute

Great Falls, United States

Logan Health Medical Center

Kalispell, United States

Community Medical Center

Missoula, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, United States

Memorial Sloan Kettering Basking Ridge

Basking Ridge, United States

Jefferson Cherry Hill Hospital

Cherry Hill, United States

Memorial Sloan Kettering Monmouth

Middletown, United States

Memorial Sloan Kettering Bergen

Montvale, United States

Sidney Kimmel Cancer Center Washington Township

Sewell, United States

Memorial Sloan Kettering Commack

Commack, United States

Glens Falls Hospital

Glens Falls, United States

Memorial Sloan Kettering Westchester

Harrison, United States

Memorial Sloan Kettering Cancer Center

New York, United States

State University of New York Upstate Medical University

Syracuse, United States

SUNY Upstate Medical Center-Community Campus

Syracuse, United States

Memorial Sloan Kettering Nassau

Uniondale, United States

Upstate Cancer Center at Verona

Verona, United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, United States

Margaret R Pardee Memorial Hospital

Hendersonville, United States

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, United States

Sanford Bismarck Medical Center

Bismarck, United States

Sanford Broadway Medical Center

Fargo, United States

Sanford Roger Maris Cancer Center

Fargo, United States

Miami Valley Hospital South

Centerville, United States

Miami Valley Hospital

Dayton, United States

Miami Valley Hospital North

Dayton, United States

Atrium Medical Center-Middletown Regional Hospital

Franklin, United States

Miami Valley Cancer Care and Infusion

Greenville, United States

ProMedica Flower Hospital

Sylvania, United States

Upper Valley Medical Center

Troy, United States

Cancer Centers of Southwest Oklahoma Research

Lawton, United States

University of Oklahoma Health Sciences Center

Oklahoma City, United States

Saint Alphonsus Cancer Care Center-Ontario

Ontario, United States

Providence Willamette Falls Medical Center

Oregon City, United States

Providence Portland Medical Center

Portland, United States

Providence Saint Vincent Medical Center

Portland, United States

Lehigh Valley Hospital-Cedar Crest

Allentown, United States

Lehigh Valley Hospital - Muhlenberg

Bethlehem, United States

Carlisle Regional Cancer Center

Carlisle, United States

Pocono Medical Center

East Stroudsburg, United States

UPMC Hillman Cancer Center Erie

Erie, United States

UPMC Cancer Centers - Arnold Palmer Pavilion

Greensburg, United States

UPMC Pinnacle Cancer Center/Community Osteopathic Campus

Harrisburg, United States

IRMC Cancer Center

Indiana, United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center

Johnstown, United States

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion

Mechanicsburg, United States

UPMC Hillman Cancer Center - Monroeville

Monroeville, United States

Jefferson Torresdale Hospital

Philadelphia, United States

UPMC-Saint Margaret

Pittsburgh, United States

University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, United States

UPMC-Passavant Hospital

Pittsburgh, United States

UPMC-Saint Clair Hospital Cancer Center

Pittsburgh, United States

UPMC Cancer Center at UPMC Northwest

Seneca, United States

UPMC Cancer Center-Uniontown

Uniontown, United States

UPMC Cancer Center-Washington

Washington, United States

Medical University of South Carolina

Charleston, United States

Avera Cancer Institute - Mitchell

Mitchell, United States

Avera Cancer Institute at Pierre

Pierre, United States

Sanford Cancer Center Oncology Clinic

Sioux Falls, United States

Avera Cancer Institute

Sioux Falls, United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, United States

Avera Cancer Institute at Yankton

Yankton, United States

Dartmouth Cancer Center - North

Saint Johnsbury, United States

VCU Massey Cancer Center at Stony Point

Richmond, United States

VCU Massey Comprehensive Cancer Center

Richmond, United States

West Virginia University Charleston Division

Charleston, United States

Aurora Cancer Care-Southern Lakes VLCC

Burlington, United States

Aurora Saint Luke's South Shore

Cudahy, United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, United States

Aurora Health Care Germantown Health Center

Germantown, United States

Aurora Cancer Care-Grafton

Grafton, United States

Aurora BayCare Medical Center

Green Bay, United States

Aurora Cancer Care-Kenosha South

Kenosha, United States

Gundersen Lutheran Medical Center

La Crosse, United States

Aurora Bay Area Medical Group-Marinette

Marinette, United States

Marshfield Medical Center-Marshfield

Marshfield, United States

Aurora Cancer Care-Milwaukee

Milwaukee, United States

Aurora Saint Luke's Medical Center

Milwaukee, United States

Aurora Sinai Medical Center

Milwaukee, United States

ProHealth D N Greenwald Center

Mukwonago, United States

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, United States

Aurora Cancer Care-Racine

Racine, United States

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, United States

Aurora Medical Center in Summit

Summit, United States

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, United States

ProHealth Waukesha Memorial Hospital

Waukesha, United States

UW Cancer Center at ProHealth Care

Waukesha, United States

Aurora Cancer Care-Milwaukee West

Wauwatosa, United States

Aurora West Allis Medical Center

West Allis, United States

Marshfield Medical Center - Weston

Weston, United States

Trial contact

Site Public Contact

Omar T. Atiq

PRINCIPAL_INVESTIGATOR

Site Public Contact

Harlan A. Pinto

PRINCIPAL_INVESTIGATOR

Site Public Contact

Steven R. Schuster

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Karng S. Log

PRINCIPAL_INVESTIGATOR

Site Public Contact

Mike Cusnir

PRINCIPAL_INVESTIGATOR

Christopher M. Reynolds

PRINCIPAL_INVESTIGATOR

John M. Schallenkamp

PRINCIPAL_INVESTIGATOR

Site Public Contact

Peter J. Polewski

PRINCIPAL_INVESTIGATOR

Ari J. Rosenberg

PRINCIPAL_INVESTIGATOR

Site Public Contact

Bryan A. Faller

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Fahrettin Covut

PRINCIPAL_INVESTIGATOR

Christine Auberle

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Joseph J. Merchant

PRINCIPAL_INVESTIGATOR

Site Public Contact

Deborah W. Wilbur

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Prakash C. Neupane

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Ranee Mehra

PRINCIPAL_INVESTIGATOR

Site Public Contact

Peter C. Everett

PRINCIPAL_INVESTIGATOR

Site Public Contact

Daniel Almquist

PRINCIPAL_INVESTIGATOR

Daniel M. Anderson

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Jay W. Carlson

PRINCIPAL_INVESTIGATOR

Joerg Rathmann

PRINCIPAL_INVESTIGATOR

Site Public Contact

Alan L. Ho

PRINCIPAL_INVESTIGATOR

Site Public Contact

Aqeel A. Gillani

PRINCIPAL_INVESTIGATOR

Site Public Contact

Komal Akhtar

PRINCIPAL_INVESTIGATOR

Siddharth Sheth

PRINCIPAL_INVESTIGATOR

John K. Hill

PRINCIPAL_INVESTIGATOR

Charles S. Kuzma

PRINCIPAL_INVESTIGATOR

Tarek M. Sabagh

PRINCIPAL_INVESTIGATOR

Site Public Contact

Chang Xia

PRINCIPAL_INVESTIGATOR

Site Public Contact

Minh Phan

PRINCIPAL_INVESTIGATOR

Alison K. Conlin

PRINCIPAL_INVESTIGATOR

Dan P. Zandberg

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

Site Public Contact

John M. Kaczmar

PRINCIPAL_INVESTIGATOR

Benjamin M. Solomon

PRINCIPAL_INVESTIGATOR

Site Public Contact

Erin R. Alesi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Kok Hoe Chan

PRINCIPAL_INVESTIGATOR

Site Public Contact

Seth O. Fagbemi

PRINCIPAL_INVESTIGATOR

Michael O. Ojelabi

PRINCIPAL_INVESTIGATOR

Site Public Contact

Timothy R. Wassenaar

PRINCIPAL_INVESTIGATOR

Site Public Contact

Site Public Contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/9/2026.

You can help another person

We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.