A Phase 1/2, Open-label, Multicenter, FIH Study to Evaluate Safety, Tolerability, PK and Anti-tumor Activity of YH42946
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this YH42946-101 is to evaluate the safety, Tolerability, Pharmacokinetics and anti-tumor activity of YH42946 in patients with locally advanced of metastatic solid tumors with HER2 aberration and EGFR exon 20 insertions.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dobry stan ogólny (możliwość normalnego funkcjonowania bez lub z małymi ograniczeniami)
- •Przewidywana długość życia co najmniej 3 miesiące
- •Nowotwór przeszedł poprzednie standardowe leczenie lub pacjent nie może być poddawany standardowym terapiom
- •Próbka guza potwierdza mutację HER2 lub EGFR
- •Jeśli były przerzuty do mózgu - wszystkie ogniska musiały być już leczone
- •Prawidłowa funkcja szpiku kostnego, wątroby, nerek i serca
- •Prawidłowe parametry krzepnięcia krwi
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (8)
Next Oncology Virginia
Fairfax, United States
Seoul National University Bundang Hospital
Seongnam-si, South Korea
The Catholic Univ. of Korea St. Vincent's Hospital
Suwon, South Korea
Chungbuk National University Hospital
Cheongju-si, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Asan Medical Center, University of Ulsan
Seoul, South Korea
Trial contact
Yuhan Corporation Clinical Operation Team 1
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/18/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.