RecruitingPhase III🇵🇱 PolandEN originalLung cancer

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene and pembrolizumab after surgery can help prevent the cancer from coming back in people with non-small cell lung cancer (NSCLC) whose tumors did not respond completely to treatment before surgery (neoadjuvant treatment).

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Zdiagnozowany rak płuca (typ niedrobnokomórkowy), który można usunąć chirurgicznie, a choroba jest we wczesnym stadium (II lub IIIA, IIIB z przerzutami do węzłów chłonnych N2).
  • Pacjent jest w dobrym stanie ogólnym, potrafi samodzielnie funkcjonować.
  • Leczenie przed operacją (chemioterapia i lek) nie usunęło całkowicie guza.
  • Badania nie wykazały zmian w genie EGFR, które wymagałyby innego leczenia.
  • Osoby zakażone wirusem HIV mogą brać udział, jeśli wirus jest dobrze kontrolowany lekami.
  • Osoby zakażone wirusem zapalenia wątroby typu B (WZW B) mogą brać udział, jeśli wirus jest kontrolowany lekami i nie jest wykrywalny.
  • Osoby z historią zakażenia wirusem zapalenia wątroby typu C (WZW C) mogą brać udział, jeśli wirus nie jest wykrywalny.

✗ Disqualifies

  • Zdiagnozowany rak płuca (typ drobnokomórkowy) lub inne rzadkie rodzaje raka płuca.
  • Stwierdzone zmiany w genie ALK, które wymagają innego leczenia.
  • Otrzymane jakiekolwiek leczenie przed operacją raka płuca w ramach tego badania.
  • Otrzymane wcześniej leczenie lekami działającymi na białka PD-1, PD-L1 lub PD-L2.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 6, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (236)

Banner MD Anderson Cancer Center ( Site 0181)

Gilbert, United States

The University of Arizona Cancer Center - North Campus ( Site 0163)

Tucson, United States

Providence St. Jude Medical Center ( Site 0106)

Fullerton, United States

VA Long Beach Healthcare System ( Site 0199)

Long Beach, United States

USC Norris Comprehensive Cancer Center ( Site 0205)

Los Angeles, United States

UCLA Jonsson Comprehensive Cancer Center ( Site 0135)

Los Angeles, United States

UCSF Medical Center at Mission Bay ( Site 0178)

San Francisco, United States

University of Colorado Anschutz Medical Campus ( Site 0151)

Aurora, United States

UCHealth Memorial Hospital Central ( Site 0125)

Colorado Springs, United States

Banner MD Anderson Cancer Center at North Colorado Medical Center ( Site 0207)

Greeley, United States

Centura Health - St. Anthony North Health Campus ( Site 0189)

Westminster, United States

Yale University School of Medicine ( Site 0201)

New Haven, United States

Eastern CT Hematology & Oncology Associates ( Site 0202)

Norwich, United States

The Oncology Institute of Hope and Innovation - Fort Lauderdale ( Site 0156)

Fort Lauderdale, United States

Miami Cancer Institute at Baptist Health, Inc. ( Site 0214)

Miami, United States

Beacon Cancer Care ( Site 0127)

Post Falls, United States

The University of Chicago Medical Center ( Site 0118)

Chicago, United States

Maryland Oncology Hematology (MOH) ( Site 8102)

Rockville, United States

Massachusetts General Hospital ( Site 0136)

Boston, United States

Dana Farber Cancer Hospital ( Site 0155)

Boston, United States

Ellis Fischel Cancer Center ( Site 0133)

Columbia, United States

Lake Regional Hospital-Cancer Center ( Site 0123)

Osage Beach, United States

Roswell Park Cancer Institute ( Site 0184)

Buffalo, United States

Hematology-Oncology Associates of CNY ( Site 0164)

East Syracuse, United States

The Blavatnik Family- Chelsea Medical Center at Mount Sinai ( Site 0216)

New York, United States

Icahn School of Medicine at Mount Sinai ( Site 0116)

New York, United States

Memorial Sloan Kettering Cancer Center ( Site 0137)

New York, United States

SUNY Upstate Cancer Center ( Site 0140)

Syracuse, United States

Montefiore Medical Center ( Site 0160)

The Bronx, United States

Westchester Medical Center ( Site 0196)

Valhalla, United States

Novant Health Weisiger Cancer Insititute ( Site 0266)

Charlotte, United States

Novant Health Forsyth Medical Center ( Site 0166)

Winston-Salem, United States

University of Cincinnati Medical Center ( Site 0119)

Cincinnati, United States

St. Lukes Hospital and Health Network ( Site 0186)

Bethlehem, United States

Tennessee Oncology, PLLC - Chattanooga Downtown ( Site 0315)

Chattanooga, United States

Thompson Cancer Survival Center ( Site 0168)

Knoxville, United States

Elliston Place Medical Oncology & Hematology ( Site 0215)

Nashville, United States

Texas Oncology - DFW ( Site 8103)

Dallas, United States

UT Southwestern Medical Center ( Site 0190)

Dallas, United States

Houston Methodist Cancer Center ( Site 0191)

Houston, United States

MD Anderson Cancer Center ( Site 0150)

Houston, United States

Memorial Hermann Cancer Center ( Site 0172)

Houston, United States

Michael E. DeBakey VA Medical Center ( Site 0197)

Houston, United States

O'Quinn Medical Tower at McNair Campus ( Site 0131)

Houston, United States

The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0148)

Tyler, United States

Virginia Cancer Specialists ( Site 0167)

Fairfax, United States

Virginia Oncology Associates (VOA) ( Site 8101)

Norfolk, United States

VCU Health Adult Outpatient Pavillion ( Site 0193)

Richmond, United States

Swedish Cancer Institute ( Site 0143)

Seattle, United States

St. Joseph Medical Center Hematology and Oncology - Silverdale ( Site 0192)

Silverdale, United States

CEMIC ( Site 2454)

Caba., Argentina

Hospital Italiano de Buenos Aires-Clinical Oncology ( Site 2459)

Ciudad Autonoma de Buenos Aires., Argentina

Fundacion Intecnus ( Site 2456)

Bariloche, Argentina

Centro Médico IPAM ( Site 2452)

Rosario, Argentina

Instituto Medico Especializado Alexander Fleming ( Site 2457)

Buenos Aires, Argentina

Instituto Oncologico de Cordoba -IONC ( Site 2455)

Córdoba, Argentina

Calvary Mater Newcastle ( Site 2106)

Waratah, Australia

Tasman Oncology Research ( Site 2104)

Southport, Australia

Princess Alexandra Hospital ( Site 2102)

Woolloongabba, Australia

Grampians Health ( Site 2101)

Ballarat, Australia

One Clinical Research ( Site 2103)

Nedlands, Australia

Cliniques Universitaires Saint-Luc ( Site 1203)

Brussels, Belgium

Jessa Ziekenhuis ( Site 1204)

Hasselt, Belgium

UZ Gent ( Site 1201)

Ghent, Belgium

CRIO - CENTRO REGIONAL INTEGRADO DE ONCOLOGIA ( Site 2502)

Fortaleza, Brazil

Hospital Araújo Jorge ( Site 2514)

Goiânia, Brazil

Liga Norte Riograndense Contra o Cancer ( Site 2513)

Natal, Brazil

Hospital Tacchini ( Site 2506)

Bento Gonçalves, Brazil

Hospital de Clínicas de Passo Fundo ( Site 2504)

Passo Fundo, Brazil

Hospital Moinhos de Vento ( Site 2510)

Porto Alegre, Brazil

Hospital Nossa Senhora Da Conceicao ( Site 2512)

Porto Alegre, Brazil

Instituto de Oncologia Saint Gallen ( Site 2507)

Santa Cruz do Sul, Brazil

Hospital de Amor - Barretos ( Site 2511)

Barretos, Brazil

Instituto Nacional de Câncer - INCA ( Site 2501)

Rio de Janeiro, Brazil

MBAL Uni Hospital ( Site 1253)

Panagyurishte, Bulgaria

MHAT - Heart and Brain ( Site 1252)

Pleven, Bulgaria

Queen Elizabeth II Health Sciences Centre ( Site 1101)

Halifax, Canada

Hamilton Health Sciences - Juravinski Site ( Site 1104)

Hamilton, Canada

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 1105)

Kingston, Canada

Lakeridge Health ( Site 1107)

Oshawa, Canada

Sunnybrook Research Institute ( Site 1106)

Toronto, Canada

McGill University Health Centre ( Site 1103)

Montreal, Canada

IUCPQ ( Site 1112)

Québec, Canada

Orlandi Oncologia ( Site 2555)

Santiago, Chile

FALP ( Site 2551)

Santiago, Chile

Clínica RedSalud Vitacura ( Site 2556)

Santiago, Chile

Bradfordhill ( Site 2552)

Santiago, Chile

ONCOCENTRO APYS ( Site 2554)

Viña del Mar, Chile

Bradford Hill Norte ( Site 2563)

Antofagasta, Chile

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 2603)

Bogotá, Colombia

Hospital Universitario San Ignacio ( Site 2610)

Bogotá, Colombia

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 2604)

Bogotá, Colombia

IMAT S.A.S ( Site 2602)

Montería, Colombia

Oncologos del Occidente ( Site 2608)

Pereira, Colombia

Fundacion Valle del Lili- CIC ( Site 2601)

Cali, Colombia

Oulun yliopistollinen sairaala ( Site 1301)

Oulu, Finland

Turku University Hospital ( Site 1303)

Turku, Finland

Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre ( Site 1359)

Caen, France

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau ( Site 1354)

Tours, France

CHU Besançon ( Site 1358)

Besançon, France

Institut De Cancerologie De L Ouest ( Site 1357)

Saint-Herblain, France

Institut Cœur Poumon -CHU Lille ( Site 1352)

Lille, France

CENTRE LEON BERARD ( Site 1351)

Lyon, France

Pitie Salpetriere University Hospital ( Site 1355)

Paris, France

Gustave Roussy ( Site 1353)

Villejuif, France

Thoraxklinik-Heidelberg gGmbH ( Site 1412)

Heidelberg, Germany

Robert-Bosch-Krankenhaus ( Site 1401)

Stuttgart, Germany

Klinikverbund Allgäu gGmbH ( Site 1408)

Kempten (Allgäu), Germany

UKGM Gießen/Marburg ( Site 1404)

Giessen, Germany

Pius Hospital Oldenburg ( Site 1407)

Oldenburg, Germany

St.-Antonius-Hospital ( Site 1411)

Eschweiler, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus ( Site 1405)

Münster, Germany

Marienhaus Klinikum Mainz ( Site 1403)

Mainz, Germany

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 1452)

Pátrai, Greece

Errikos Dunant Hospital Center ( Site 1457)

Athens, Greece

THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 1451)

Athens, Greece

Metropolitan Hospital ( Site 1459)

Athens, Greece

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1460)

Chaïdári, Greece

University General Hospital of Herakleion ( Site 1458)

Heraklion, Greece

University General Hospital of Larissa-Oncology Clinic ( Site 1453)

Larissa, Greece

Papageorgiou General Hospital of Thessaloniki ( Site 1454)

Thessaloniki, Greece

Fejér Megyei Szent György Egyetemi Oktató Kórház ( Site 1506)

Székesfehérvár, Hungary

Petz Aladár Megyei Oktató Kórház ( Site 1502)

Győr, Hungary

Debreceni Egyetem Altalanos Orvostudomanyi Kar Tudogyogyaszati Tanszek ( Site 1508)

Debrecen, Hungary

Mátrai Gyógyintézet ( Site 1504)

Mátraháza, Hungary

Reformatus Pulmonologiai Centrum-Onkopulmonologiai Jarobeteg Centrum ( Site 1505)

Törökbálint, Hungary

Somogy Vármegyei Kaposi Mór Oktató Kórház-Oncology center ( Site 1507)

Kaposvár, Hungary

Orszagos Koranyi Pulmonologiai Intezet ( Site 1501)

Budapest, Hungary

Cork University Hospital ( Site 1553)

Cork, Ireland

St. James's Hospital ( Site 1554)

Dublin, Ireland

Tallaght University Hospital ( Site 1551)

Dublin, Ireland

Rambam Health Care Campus ( Site 1603)

Haifa, Israel

Shaare Zedek Medical Center ( Site 1601)

Jerusalem, Israel

Hadassah Medical Center ( Site 1605)

Jerusalem, Israel

Meir Medical Center ( Site 1606)

Kfar Saba, Israel

Sheba Medical Center ( Site 1602)

Ramat Gan, Israel

AOU Renato Dulbecco ( Site 1661)

Catanzaro, Italy

Ospedale Santa Maria delle Croci ( Site 1652)

Ravenna, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 1653)

Rome, Italy

Fondazione Policlinico Universitario Campus Bio-Medico ( Site 1660)

Rome, Italy

Istituto Nazionale Tumori Regina Elena ( Site 1651)

Rome, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1656)

Milan, Italy

IEO Istituto Europeo di Oncologia ( Site 1655)

Milan, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1657)

Naples, Italy

IRCCS Istituto Oncologico Veneto ( Site 1654)

Padova, Italy

Centro Ricerche Cliniche di Verona ( Site 1659)

Verona, Italy

Hospital of the University of Occupational and Environmental Health, Japan ( Site 1166)

Kitakyushu, Japan

St. Marianna University Hospital ( Site 1159)

Kawasaki, Japan

Kanagawa Cancer Center ( Site 1158)

Yokohama, Japan

Kindai University Hospital ( Site 1162)

Sakai, Japan

Shizuoka Cancer Center ( Site 1160)

Sunto-gun, Japan

Dokkyo Medical University Hospital ( Site 1152)

Shimotsuga-gun, Japan

National Cancer Center Hospital ( Site 1156)

Chūō, Japan

Tokyo Medical University Hospital ( Site 1157)

Shinjuku, Japan

Chiba University Hospital ( Site 1154)

Chiba, Japan

National Hospital Organization Kyushu Cancer Center ( Site 1167)

Fukuoka, Japan

Fukushima Medical University Hospital ( Site 1151)

Fukushima, Japan

Hiroshima University Hospital ( Site 1165)

Hiroshima, Japan

Okayama University Hospital ( Site 1164)

Okayama, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1161)

Osaka, Japan

Wakayama Medical University Hospital ( Site 1163)

Wakayama, Japan

Radboudumc ( Site 1706)

Nijmegen, Netherlands

Maastricht UMC+ ( Site 1705)

Maastricht, Netherlands

Jeroen Bosch Hospital ( Site 1701)

's-Hertogenbosch, Netherlands

Frisius Medisch Centrum ( Site 1702)

Leeuwarden, Netherlands

Meander Medisch Centrum ( Site 1703)

Amersfoort, Netherlands

University Medical Center Groningen ( Site 1707)

Groningen, Netherlands

Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 2201)

Tauranga, New Zealand

Dunedin Hospital ( Site 2202)

Dunedin, New Zealand

Waikato Hospital ( Site 2204)

Hamilton, New Zealand

Aliada ( Site 2753)

Lima, Peru

Clínica Internacional - Sede San Borja ( Site 2752)

Lima, Peru

Detecta Clínica ( Site 2751)

Lima, Peru

Wielkopolskie Centrum Pulmonologii i Torakochirurgii ( Site 1763)

Poznan, Poland

Krakowski Szpital Specjalistyczny im. Jana Pawla II ( Site 1756)

Krakow, Poland

Dolnoslaskie Centrum Onkologii Pulmonologii i Hematologii ( Site 1765)

Wroclaw, Poland

Instytut Gruzlicy i Chorob Pluc w Warszawie ( Site 1764)

Warsaw, Poland

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1759)

Przemyśl, Poland

Uniwersyteckie Centrum Kliniczne ( Site 1758)

Gdansk, Poland

Warmińsko - Mazurskie Centrum Chorób Płuc w Olsztynie ( Site 1760)

Olsztyn, Poland

Swietokrzyskie Centrum Onkologii. ( Site 1754)

Kielce, Poland

Centrul Medical Medicover Victoria ( Site 1802)

Bucharest, Romania

Cabinet Medical Oncomed ( Site 1803)

Timișoara, Romania

S.C. ONCO CARD S.R.L ( Site 1805)

Brasov, Romania

Institutul Regional de Oncologie ( Site 1804)

Iași, Romania

National Cancer Centre Singapore ( Site 2251)

Singapore, Singapore

Tan Tock Seng Hospital ( Site 2252)

Singapore, Singapore

National Cancer Center ( Site 2305)

Goyang-si, South Korea

The Catholic University of Korea St. Vincent s Hospital ( Site 2301)

Suwon, South Korea

Ajou University Hospital ( Site 2306)

Suwon, South Korea

Seoul National University Hospital ( Site 2303)

Seoul, South Korea

Severance Hospital Yonsei University Health System ( Site 2302)

Seoul, South Korea

Samsung Medical Center ( Site 2304)

Seoul, South Korea

Seoul St. Mary's Hospital ( Site 2307)

Seoul, South Korea

Hospital Insular de Gran Canaria ( Site 1911)

Canarias, Spain

Complejo Hospitalario Universitario A Coruna ( Site 1916)

A Coruña, Spain

Hospital Universitario Quiron Madrid ( Site 1913)

Pozuelo de Alarcón, Spain

Hospital Universitari Vall D Hebron ( Site 1910)

Barcelona, Spain

Hospital Clinic de Barcelona ( Site 1919)

Barcelona, Spain

Hospital General Universitario Gregorio Maranon ( Site 1912)

Madrid, Spain

Hospital Quiron Malaga ( Site 1914)

Málaga, Spain

Karolinska Universitetssjukhuset Solna ( Site 1951)

Stockholm, Sweden

Chung Shan Medical University Hospital ( Site 2351)

Taichung, Taiwan

China Medical University Hospital ( Site 2358)

Taichung, Taiwan

National Cheng Kung University Hospital ( Site 2354)

Tainan, Taiwan

National Taiwan University Cancer Center (NTUCC) ( Site 2360)

Taipei, Taiwan

Mackay Memorial Hospital ( Site 2355)

Taipei, Taiwan

Taipei Medical University Hospital ( Site 2352)

Taipei, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center ( Site 2359)

Taipei, Taiwan

Taipei Veterans General Hospital ( Site 2357)

Taipei, Taiwan

Chang Gung Memorial Hospital ( Site 2361)

Taoyuan, Taiwan

Faculty of Medicine Siriraj Hospital ( Site 2403)

Bangkoknoi, Thailand

Ramathibodi Hospital ( Site 2405)

Ratchathewi, Thailand

Faculty of Medicine - Khon Kaen University ( Site 2401)

Muang, Thailand

Songklanagarind Hospital ( Site 2402)

Hat Yai, Thailand

Maharaj Nakorn Chiang Mai Hospital ( Site 2404)

Muang, Thailand

Hacettepe Universite Hastaneleri ( Site 2001)

Sıhhiye, Turkey (Türkiye)

Sakarya Universitesi Tip Fakultesi Hastanesi ( Site 2006)

Adapazarı, Turkey (Türkiye)

Namık Kemal University Medical Faculty ( Site 2007)

Tekirdağ, Turkey (Türkiye)

Adana Medical Park Seyhan Hastanesi ( Site 2010)

Adana, Turkey (Türkiye)

Ankara Bilkent Sehir Hastanesi ( Site 2002)

Ankara, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi ( Site 2003)

Istanbul, Turkey (Türkiye)

Erciyes Universitesi Tıp Fakultesi Hastaneleri ( Site 2009)

Kayseri, Turkey (Türkiye)

Karadeniz Technical University ( Site 2008)

Trabzon, Turkey (Türkiye)

Bristol Haematology and Oncology Centre ( Site 2072)

Bristol, United Kingdom

ROYAL MARSDEN HOSPITAL (CHELSEA)-Lung Unit ( Site 2075)

London, United Kingdom

St Bartholomews Hospital ( Site 2052)

London, United Kingdom

Royal Free Hospital ( Site 2074)

London, United Kingdom

Guys Hospital ( Site 2057)

London, United Kingdom

Royal Marsden Hospital (Sutton) ( Site 2076)

London, United Kingdom

Nottingham City Hospital ( Site 2058)

Nottingham, United Kingdom

St James University Hospital ( Site 2055)

Leeds, United Kingdom

Leicester Royal Infirmary ( Site 2051)

Leicester, United Kingdom

The Christie NHS Foundation Trust ( Site 2066)

Manchester, United Kingdom

The Clatterbridge Cancer Centre ( Site 2069)

Metropolitan Borough of Wirral, United Kingdom

Queen Alexandra Hospital ( Site 2059)

Portsmouth, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/7/2026.

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