RecruitingPhase III🇵🇱 PolandMale onlyEN original

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This study will explore whether a combination of the investigational drug PF-06821497 and enzalutamide will work better than taking enzalutamide alone in participants with mCRPC who are ARSi or abiraterone naïve.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony rak prostaty (bez cech raka drobnokomórkowego).
  • Rozsiane zmiany (w kościach lub tkankach miękkich), potwierdzone badaniami obrazowymi.
  • Postęp choroby mimo kastracji medycznej lub chirurgicznej.
  • Pacjent czuje się na tyle dobrze, że może wykonywać codzienne czynności (stan sprawności ECOG 0 lub 1) i ma przewidywaną długość życia co najmniej 12 miesięcy.

✗ Disqualifies

  • Choroby lub problemy psychiczne, w tym myśli samobójcze w ciągu ostatniego roku lub zachowania samobójcze w ciągu ostatnich 5 lat.
  • Problemy z żołądkiem lub jelitami, np. choroby zapalne jelit, przewlekłe biegunki, przebyte operacje żołądka.
  • Poważne choroby serca.
  • Problemy z mózgiem (np. przerzuty do mózgu), choroby opon mózgowych, drgawki.
  • Wcześniejsze choroby szpiku kostnego lub inne nowotwory (z pewnymi wyjątkami).
  • Pacjenci, którzy wcześniej byli leczeni lekami na zaawansowanego raka prostaty, takimi jak chemioterapia, terapie celowane (np. PSMA), inhibitory CDK4/6, inhibitory 5-alfa-reduktazy, inhibitory receptora androgenowego (jak enzalutamid, apalutamid, darolutamid), czy terapie PARP (z pewnymi wyjątkami).

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 1, 2026
Sex
Male only

Therapies / drugs in trial

Locations (241)

Ironwood Cancer & Research Centers

Chandler, United States

Ironwood Cancer & Research Centers

Gilbert, United States

Palo Verde Hematology Oncology

Glendale, United States

Ironwood Cancer & Research Centers

Glendale, United States

Ironwood Cancer & Research Centers

Goodyear, United States

Ironwood Cancer & Research Centers

Mesa, United States

Ironwood Cancer & Research Centers

Mesa, United States

Ironwood Cancer & Research Centers

Phoenix, United States

Ironwood Cancer & Research Centers

Scottsdale, United States

Highlands Oncology

Fayetteville, United States

Arkansas Urology - Little Rock

Little Rock, United States

Highlands Oncology

Rogers, United States

Highlands Oncology Group

Springdale, United States

Los Angeles Cancer Network (LACN)

Anaheim, United States

Los Angeles Cancer Network (LACN)

Fountain Valley, United States

Los Angeles Cancer Network (LACN)

Glendale, United States

Los Angeles Cancer Network (LACN)

Glendale, United States

Los Angeles Cancer Network (LACN)

Laguna Hills, United States

Los Angeles Cancer Network (LACN)

Los Angeles, United States

Los Angeles Cancer Network (LACN)

Los Angeles, United States

Medical Oncology Associates of San Diego

San Diego, United States

Accellacare of Duly

Lisle, United States

Duly Health and Care (Bone Scintigraphy)

Lisle, United States

Blessing Hospital

Quincy, United States

Blessing Physician Services

Quincy, United States

Duly Health and Care (CT and MRI)

Westmont, United States

Adult & Pediatric Urology, PC

Omaha, United States

CHRISTUS St. Vincent Regional Cancer Center

Santa Fe, United States

Montefiore Medical Center - Medical Park

The Bronx, United States

Montefiore Medical Center

The Bronx, United States

Salisbury VA Medical Center

Salisbury, United States

AUC Urologists, LLC

Myrtle Beach, United States

Carolina Urologic Research Center, LLC

Myrtle Beach, United States

Grand Strand Medical Center

Myrtle Beach, United States

Parkway Surgery Center

Myrtle Beach, United States

USA Clinical Trials

San Antonio, United States

Northwest Medical Specialties, PLLC

Bonney Lake, United States

Northwest Medical Specialties, PLLC

Federal Way, United States

Northwest Medical Specialties, PLLC

Gig Harbor, United States

Northwest Medical Specialties, PLLC

Puyallup, United States

Harborview Medical Center

Seattle, United States

Fred Hutchinson Cancer Center

Seattle, United States

University of Washington Medical Center - Montlake

Seattle, United States

Northwest Medical Specialties, PLLC

Tacoma, United States

Centro de Urología (CDU)

CABA, Argentina

Hospital Sirio Libanes

Capital Federal, Argentina

Imagenes Mdq

Mar del Plata, Argentina

Instituto de Investigaciones Clínicas Mar del Plata

Mar del Plata, Argentina

Centro Medico Privado CEMAIC

Capital, Argentina

IMAXE

Buenos Aires, Argentina

Centro Medico Fleischer

Buenos Aires, Argentina

Hospital Privado Centro Médico de Córdoba

Córdoba, Argentina

Oncocentro Servico Medicos e Hospitalares Ltda

Fortaleza, Brazil

Hospital São Carlos

Fortaleza, Brazil

Oncocentro Oncologia

Fortaleza, Brazil

Instituto D'Or de Pesquisa e Ensino

Fortaleza, Brazil

Crio - Centro Regional Integrado de Oncologia

Fortaleza, Brazil

Instituto D'Or de Pesquisa e Ensino (IDOR) - Filial Salvador

Salvador, Brazil

Clinica Amo - Rio Vermelho

Salvador, Brazil

Clinica Amo - Rio Vermelho

Salvador, Brazil

Hospital Sirio Libanes

Brasília, Brazil

Liga Norte Riograndense Contra o Câncer

Natal, Brazil

Hospital São Lucas da PUCRS

Porto Alegre, Brazil

MedPlex Eixo Norte

Porto Alegre, Brazil

Hospital Nossa Senhora da Conceição

Porto Alegre, Brazil

Fundação Pio XII - Hospital de Câncer de Barretos

Barretos, Brazil

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

Santo André, Brazil

Fundação Faculdade Regional de Medicina de São José do Rio Preto

São José do Rio Preto, Brazil

Hospital Alemao Oswaldo Cruz

São Paulo, Brazil

Instituto do Cancer Arnaldo Vieira de Carvalho

São Paulo, Brazil

IBCC - Núcleo de Pesquisa e Ensino

São Paulo, Brazil

"University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski" EAD

Pleven, Bulgaria

Complex Oncology Center - Plovdiv EOOD

Plovdiv, Bulgaria

University Multiprofile Hospital for Active Treatment Sofiamed

Sofia, Bulgaria

Complex Oncology Center Stara Zagora EOOD

Stara Zagora, Bulgaria

Prostate Cancer Centre

Calgary, Canada

Cross Cancer Institute

Edmonton, Canada

QEII Health Sciences Centre - Victoria General Site

Halifax, Canada

Lakeridge Health

Oshawa, Canada

CIUSSS- saguenay-Lac-Saint-Jean

Chicoutimi, Canada

Centre Hospitalier de l'Université de Montréal

Montreal, Canada

Centro de Investigacion Clinica del Sur

Temuco, Chile

IC La Serena Research

La Serena, Chile

Clinica Universidad Catolica del Maule

Talca, Chile

Fundación Arturo López Pérez

Providencia, Chile

Fundacion Arturo Lopez Perez

Providencia, Chile

Oncovida

Providencia, Chile

Centro de Estudios Clínicos SAGA

Santiago, Chile

FALP

Santiago, Chile

Bradfordhill

Santiago, Chile

Oncocentro Apys

Viña del Mar, Chile

Wannan Medical College Yijishan Hospital

Wuhu, China

Cancer Hospital Chinese Academy of Medical Science

Beijing, China

Fujian Cancer Hospital

Fuzhou, China

Guangzhou First People's Hospital

Guangzhou, China

The Second Affiliated Hospital of Shantou University School of Medicine

Shantou, China

The Second Affiliated Hospital of Guilin Medical University

Guilin, China

The Third Affiliated Hospital of Xinxiang Medical University

Xinxiang, China

Henan Cancer Hospital

Zhengzhou, China

Union Hospital Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

Hunan Cancer Hospital

Changsha, China

Inner Mongolia People's Hospital

Hohhot, China

Huai'an First People's Hospital

Huai'an, China

Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School

Nanjing, China

Nantong Tumor Hospital

Nantong, China

The Second Affiliated Hospital of Soochow University

Suzhou, China

The First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, China

Shaanxi Provincial People' Hospital

Xi'an, China

Shandong Provincial Hospital

Jinan, China

The Affiliated Hospital of Qingdao University

Qingdao, China

Weifang People's Hospital

Weifang, China

Yantai Yuhuangding Hospital

Yantai, China

Tongji Hospital of Tongji University

Shanghai, China

West China Hospital, Sichuan University

Chengdu, China

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine

Hangzhou, China

The first affiliated hospital of Ningbo university

Ningbo, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China

The First Hospital of Jiaxing

Jiaxing, China

Peking University Third Hospital

Beijing, China

First Affiliated Hospital of China Medical University

Shenyang, China

The Second Hospital of Tianjin Medical University

Tianjin, China

Fakultni nemocnice Ostrava

Ostrava, Czechia

Fakultní nemocnice Ostrava

Ostrava - Poruba, Czechia

Fakultni nemocnice Olomouc

Olomouc, Czechia

Multiscan

Pardubice, Czechia

Fakultni nemocnice Kralovske Vinohrady

Prague, Czechia

Urocentrum Praha

Prague, Czechia

Fakultni Thomayerova nemocnice

Prague, Czechia

Krajská nemocnice Liberec

Liberec, Czechia

Næstved Sygehus

Næstved, Denmark

Odense Universitetshospital

Odense, Denmark

Vejle Sygehus

Vejle, Denmark

Oulun yliopistollinen sairaala

Oulu, Finland

Kuopion Yliopistollinen Sairaala

Kuopio, Finland

Tampereen yliopistollinen sairaala

Tampere, Finland

Turku University Hospital

Turku, Finland

Helsinki university hospital

Helsinki, Finland

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux, France

Centre Leon Berard

Lyon Cedex08, France

Hopitaux Universitaire de Strasbourg - Hopital Hautepierre

Strasbourg, France

CHRU de Brest

Brest, France

Centre Hospitalier Privé Saint-Grégoire

Saint-Grégoire, France

Institut de Cancérologie de l'Ouest

Saint-Herblain, France

Institut Jean Godinot

Reims, France

Clinique Victor Hugo Le Mans

Le Mans, France

Centre Hospitalier Lyon Sud

Pierre-Bénite, France

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne

Clermont-Ferrand, France

Institut Godinot

Reims, France

Studienpraxis Urologie

Nürtingen, Germany

Universitaetsklinikum Tuebingen

Tübingen, Germany

Universitätsklinikum Münster - Albert Schweitzer Campus

Münster, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

University Hospital of Patras

Pátrai, Greece

Alexandra General Hospital of Athens

Athens, Greece

Athens Medical Center

Athens, Greece

University General Hospital "ATTIKON" - General Hospital of West Attica "H AGIA VARVARA"

Chaïdári, Greece

University General Hospital of Larissa

Larissa, Greece

Borsod-Abaúj-Zemplén Vármegyei Központi Kórház és Egyetemi Oktatókórház

Miskolc, Hungary

Petz Aladar Egyetemi Oktato Korhaz

Győr, Hungary

Nograd Varmegyei Szent Lazar Korhaz

Salgótarján, Hungary

Országos Onkológiai Intézet

Budapest, Hungary

IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"

Meldola, Italy

Istituto Nazionale Tumori Regina Elena

Rome, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore

Rome, Italy

IRCCS Istituto Clinico Humanitas

Rozzano, Italy

Azienda Socio Sanitaria Territoriale di Cremona

Cremona, Italy

Ospedale San Raffaele

Milan, Italy

Istituto Nazionale Tumori IRCCS Fondazione Pascale

Naples, Italy

Azienda Ospedaliera Santa Maria Terni

Terni, Italy

APSS- Presidio Ospedaliero S. Chiara

Trento, Italy

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma

Verona, Italy

Chiba cancer center

Chiba, Japan

National Cancer Center Hospital East

Kashiwa, Japan

National Hospital Organization Shikoku Cancer Center

Matsuyama, Japan

National Hospital Organization Hokkaido Cancer Center

Sapporo, Japan

Hokkaido University Hospital

Sapporo, Japan

Kobe University Hospital

Kobe, Japan

Kanazawa University Hospital

Kanazawa, Japan

Yokohama City University Medical Center

Yokohama, Japan

Yokosuka Kyosai Hospital

Yokosuka, Japan

The University of Osaka Hospital

Suita, Japan

Keio university hospital

Shinjuku-ku, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan

National Hospital Organization Kumamoto Medical Center

Kumamoto, Japan

Osaka International Cancer Institute

Osaka, Japan

Yamagata University Hospital

Yamagata, Japan

Canisius-Wilhelmina Ziekenhuis

Nijmegen, Netherlands

Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)

Amsterdam, Netherlands

Frisius Medisch Centrum

Leeuwarden, Netherlands

Franciscus Gasthuis & Vlietland, Locatie Vlietland

Schiedam, Netherlands

Imed Radiology

Tauranga, New Zealand

Tauranga Hospital

Tauranga, New Zealand

Christchurch Hospital

Christchurch, New Zealand

Waikato Hospital

Hamilton, New Zealand

Auckland City Hospital

Auckland, New Zealand

Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego

Grudziądz, Poland

Centrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o.

Krakow, Poland

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie

Krakow, Poland

4 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ

Wroclaw, Poland

Clinical Best Solutions

Lublin, Poland

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie

Warsaw, Poland

Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie

Koszalin, Poland

SP ZOZ Opolskie Centrum Onkologii im. prof. Tadeusza Koszarowskiego w Opolu

Opole, Poland

Provita Profamilia

Piotrkow Trybunalski, Poland

CUIMED, s.r.o., Urologicka ambulancia

Bratislava, Slovakia

Privatna urologicka ambulancia, s.r.o.

Trenčín, Slovakia

Cancercare Langenhoven Drive Oncology Centre

Port Elizabeth, South Africa

Wilgers Oncology Centre

Pretoria, South Africa

Wits Clinical Research

Soweto, South Africa

TASK Eden

George, South Africa

Chonnam National University Hwasun Hospital

Hwasun, South Korea

National Cancer Center

Goyang-si, South Korea

Seoul National University Hospital

Seoul, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Kyungpook National University Chilgok Hospital

Daegu, South Korea

Chungnam national university hospital

Junggu, South Korea

Institut Català d'Oncologia - L'Hospitalet

L'Hospitalet de Llobregat, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Fundación Instituto Valenciano de Oncología

Valencia, Spain

Hospital Universitario Fundación Jiménez Díaz

Madrid, Spain

Hospital Universitario HM Sanchinarro

Madrid, Spain

Södersjukhuset

Stockholm, Sweden

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Hospital

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Koç Üniversitesi Hastanesi

Istanbul, Turkey (Türkiye)

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi

Istanbul, Turkey (Türkiye)

Marmara Universitesi Pendik Egitim Arastirma Hastanesi

Istanbul, Turkey (Türkiye)

I.E.U. Medical Point Hastanesi

Izmir, Turkey (Türkiye)

Sbü Gülhane Eğitim Ve Araştirma Hastanesi

Ankara, Turkey (Türkiye)

Memorial Ankara Hastanesi

Ankara, Turkey (Türkiye)

Ankara University Health Practice and Research Hospitals

Ankara, Turkey (Türkiye)

Royal Blackburn Hospital

Blackburn, United Kingdom

Mid and South Essex NHS Foundation Trust

Chelmsford, United Kingdom

Royal Derby Hospital

Derby, United Kingdom

The Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom

The Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.

A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer. | Fundacja Potrójniepozytywna