Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial evaluates whether genetic testing in prostate cancer is helpful in deciding which study treatment patients are assigned. Patient cancer tissue samples are obtained from a previous surgery or biopsy procedure and tested for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) abnormalities or mutations in their cancer. Valemetostat tosylate is in a class of medications called EZH1/EZH2 inhibitors. It blocks proteins called EZH1 and EZH2, which may help slow or stop the spread of tumor cells. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of tumor cells. Cabazitaxel injection is in a class of medications called microtubule inhibitors. It works by slowing or stopping the growth of tumor cells. Abiraterone acetate blocks tissues from making androgens (male hormones), such as testosterone. This may cause the death of tumor cells that need androgens to grow. It is a type of anti-androgen. Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of tumor cells. Lutetium Lu 177 vipivotide tetraxetan is in a class of medications called radiopharmaceuticals. It works by targeting and delivering radiation directly to tumor cells which damages and kills these cells. Assigning patients to targeted treatment based on genetic testing may help shrink or slow the cancer from growing
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnosis raka prostaty (biopsja lub badanie tkanki)
- •Obecność przerzutów raka
- •Próbka tkanki raka dostępna z ostatnich 12 miesięcy
- •Wynik testu genetycznego (badanie DNA/RNA) wykonany w certyfikowanym laboratorium
- •Wiek co najmniej 18 lat
- •Rak oporny na leczenie hormonalne (niski poziom testosteronu w krwi)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 5, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (108)
University of Alabama at Birmingham Cancer Center
Birmingham, United States
Banner University Medical Center - Tucson
Tucson, United States
University of Arizona Cancer Center-North Campus
Tucson, United States
Enloe Medical Center
Chico, United States
UC San Diego Health System - Encinitas
Encinitas, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UC San Diego Moores Cancer Center
La Jolla, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
University of California Davis Comprehensive Cancer Center
Sacramento, United States
UC San Diego Medical Center - Hillcrest
San Diego, United States
UCHealth Memorial Hospital Central
Colorado Springs, United States
Memorial Hospital North
Colorado Springs, United States
Poudre Valley Hospital
Fort Collins, United States
Cancer Care and Hematology-Fort Collins
Fort Collins, United States
UCHealth Greeley Hospital
Greeley, United States
Medical Center of the Rockies
Loveland, United States
Stamford Hospital/Bennett Cancer Center
Stamford, United States
Beebe South Coastal Health Campus
Millville, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
Beebe Health Campus
Rehoboth Beach, United States
Jupiter Medical Center
Jupiter, United States
Tripler Army Medical Center
Honolulu, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Illinois CancerCare-Bloomington
Bloomington, United States
Illinois CancerCare-Canton
Canton, United States
Carle at The Riverfront
Danville, United States
Carle Physician Group-Effingham
Effingham, United States
Illinois CancerCare-Eureka
Eureka, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Cancer Care Center of O'Fallon
O'Fallon, United States
Illinois CancerCare-Ottawa Clinic
Ottawa, United States
Illinois CancerCare-Pekin
Pekin, United States
Illinois CancerCare-Peoria
Peoria, United States
Illinois CancerCare-Peru
Peru, United States
Memorial Hospital East
Shiloh, United States
Carle Cancer Center
Urbana, United States
Illinois CancerCare - Washington
Washington, United States
McFarland Clinic - Ames
Ames, United States
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, United States
University of Kansas Cancer Center
Kansas City, United States
The University of Kansas Cancer Center - Olathe
Olathe, United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, United States
University of Kansas Health System Saint Francis Campus
Topeka, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
Saint Elizabeth Healthcare Edgewood
Edgewood, United States
Saint Elizabeth Healthcare Fort Thomas
Fort Thomas, United States
Dana-Farber Cancer Institute
Boston, United States
Dana-Farber Cancer Institute at Foxborough
Foxborough, United States
Dana Farber-Merrimack Valley
Methuen, United States
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford, United States
Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth, United States
Baystate Medical Center
Springfield, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Essentia Health Cancer Center
Duluth, United States
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, United States
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters, United States
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, United States
Siteman Cancer Center at West County Hospital
Creve Coeur, United States
Washington University School of Medicine
St Louis, United States
Siteman Cancer Center-South County
St Louis, United States
Siteman Cancer Center at Christian Hospital
St Louis, United States
Billings Clinic Cancer Center
Billings, United States
Hackensack University Medical Center
Hackensack, United States
Roswell Park Cancer Institute
Buffalo, United States
Mount Sinai Hospital
New York, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Essentia Health Cancer Center-South University Clinic
Fargo, United States
MetroHealth Medical Center
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Providence Portland Medical Center
Portland, United States
Providence Saint Vincent Medical Center
Portland, United States
Oregon Health and Science University
Portland, United States
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, United States
Gibbs Cancer Center-Gaffney
Gaffney, United States
Gibbs Cancer Center-Pelham
Greer, United States
Spartanburg Medical Center
Spartanburg, United States
SMC Center for Hematology Oncology Union
Union, United States
Vanderbilt University/Ingram Cancer Center
Nashville, United States
Parkland Memorial Hospital
Dallas, United States
UT Southwestern Simmons Cancer Center - RedBird
Dallas, United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, United States
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, United States
UT Southwestern Clinical Center at Richardson/Plano
Richardson, United States
Bon Secours Memorial Regional Medical Center
Mechanicsville, United States
Bon Secours Saint Francis Medical Center
Midlothian, United States
Bon Secours Richmond Community Hospital
Richmond, United States
Bon Secours Saint Mary's Hospital
Richmond, United States
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, United States
VCU Massey Cancer Center at Stony Point
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Cancer Institute-Edmonds
Edmonds, United States
Swedish Medical Center-First Hill
Seattle, United States
West Virginia University Charleston Division
Charleston, United States
Edwards Comprehensive Cancer Center
Huntington, United States
Marshfield Medical Center-Marshfield
Marshfield, United States
Froedtert Menomonee Falls Hospital
Menomonee Falls, United States
Medical College of Wisconsin
Milwaukee, United States
Drexel Town Square Health Center
Oak Creek, United States
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, United States
Trial contact
Rana McKay, MD
Shiva Baghaie
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/6/2026.
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