A Study of Ifinatamab Deruxtecan in Subjects With Pretreated Advanced or Metastatic Esophageal Squamous Cell Carcinoma (ESCC) (IDeate-Esophageal01)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study is designed to assess the efficacy and safety of ifinatamab deruxtecan (I-DXd) in patients with unresectable advanced or metastatic esophageal squamous cell carcinoma (ESCC) who have experienced disease progression following treatment with a platinum-based systemic therapy and an immune checkpoint inhibitor (ICI) compared with investigator's choice of chemotherapy (ICC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rakiem przełyku typu płaskonabłonkowego (zaawansowany lub z przerzutami), który nie da się operacyjnie wyleczyć
- •Choroba postępująca po leczeniu chemioterapią na bazie platyny i immunoterapią
- •Dostarczone próbki guza o wystarczającej jakości do badań
- •Co najmniej jeden mierzalny guz widoczny w tomografii komputerowej lub rezonansie magnetycznym
- •Ogólny stan zdrowia pozwalający na uczestnictwo (skala 0-1)
✗ Disqualifies
- •Wcześniejsze leczenie lekami skierowanymi na białko B7-H3 lub topoisomerazami
- •Potwierdzona inna odmiana histologiczna (gruczolakowopłaskonabłonkowy)
- •Brak możliwości podania żadnych dostępnych chemioterapii porównawczych
- •Guz naciekający blisko leżące narządy (aorta, drogi oddechowe) z wysokim ryzykiem krwawienia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 4, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (132)
Mayo Clinic Hospital
Phoenix, United States
Providence Medical Foundation
Fullerton, United States
Univ of California Irvine College of Medicine
Orange, United States
Henry Ford Health System
Detroit, United States
Mayo Clinic Rochester
Rochester, United States
MidAmerica Cancer Care - American Oncology Partners
Kansas City, United States
Morristown Medical Center
Morristown, United States
Maimonides Cancer Center
Brooklyn, United States
Penn State University Milton S. Hershey Medical Center
Hershey, United States
Baptist Cancer Center
Memphis, United States
SCRI Oncology Partners
Nashville, United States
John Peter Smith Hospital
Fort Worth, United States
Virginia Cancer Specialists
Fairfax, United States
Institut Jules Bordet
Brussels, Belgium
Cliniques Universitaires Saint-Luc
Brussels, Belgium
Antwerp University Hospital
Edegem, Belgium
UZ Leuven
Leuven, Belgium
Chu de Liege
Liège, Belgium
Anyang Cancer Hospital
Anyang, China
Beijing Cancer Hospital
Beijing, China
Jilin Cancer Hospital
Changchun, China
Changzhou Cancer Hospital
Changzhou, China
Sichuan cancer hospital
Chengdu, China
West China Hospital Sichuan University
Chengdu, China
Fujian Cancer Hospital
Fuzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
The First Affiliated Hospital of Fujian Medical University
Hefei, China
Jinan Central Hospital
Jinan, China
Shandong Cancer Hospital
Jinan, China
Affiliated Hospital of Jining Medical University
Jining, China
Guangxi Medical University Affiliated Tumor Hospital
Nanning, China
Liaoning Cancer Hospital and Institute
Shenyang, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, China
The First Affiliated Hospital of Xinxiang Medical University
Weihui, China
Hubei Cancer Hospital
Wuhan, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Zhongshan Hospital Xiamen University
Xiamen, China
Subei Peoples Hospital
Yangzhou, China
Aarhus University Hospital
Arhus N, Denmark
Rigshospitalet
Copenhagen, Denmark
Odense University Hospital. Department of Research, Oncology
Odense C, Denmark
Sainte Catherine Institut du cancer Avignon en Provence
Avignon, France
CHU Brest - Hôpital de la Cavale Blanche
Brest, France
Centre Georges François Leclerc
Dijon, France
Institut Régional du Cancer de Montpellier
Montpellier, France
Hôpital Européen Georges Pompidou
Paris, France
CHU Poitiers - Hôpital la Milétrie
Poitiers, France
Crlcc Eugene Marquis
Rennes, France
Unité de recherche clinique ICANS
Strasbourg, France
CHU Toulouse Rangueil Service dOncologie médicale
Toulouse, France
Charité - Campus Charité Mitte
Berlin, Germany
Vivantes Klinikum Im Friedrichshain
Berlin, Germany
Universitaetsklinikum Bonn Aoer
Bonn, Germany
Universitaetsklinikum Carl Gustav Carus TU Dresden
Dresden, Germany
Krankenhaus Nordwest GmbH
Frankfurt am Main, Germany
Hämatologisch Onkologische Praxis Eppendorf HOPE
Hamburg, Germany
Asklepios Klinik Altona
Hamburg, Germany
Universitaetsklinikum Jena
Jena, Germany
Universitaetsklinikum Leipzig AoeR
Leipzig, Germany
Klinikum Nuernberg Nord
Nuremberg, Germany
Universitaetsklinikum Tuebingen
Tübingen, Germany
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
Azienda Ospedaliera Universitaria Luigi Vanvitelli
Naples, Italy
IOV - Istituto Oncologico Veneto IRCCS
Padova, Italy
Fondazione Policlinico Gemelli
Rome, Italy
IRCCS Istituto Clinico Humanitas
Rozzano, Italy
National Cancer Center Hospital
Chūōku, Japan
Hiroshima University Hospital
Hiroshima, Japan
National Cancer Center Hospital East
Kashiwa, Japan
Kagawa University Hospital
Kita-gun, Japan
Kobe City Hospital Organization Kobe City Medical Center General Hospital
Kobe, Japan
Cancer Institute Hospital of JFCR
Kōtoku, Japan
Shikoku Cancer Center
Matsuyama, Japan
Aichi Cancer Center
Nagoya, Japan
Osaka International Cancer Institute
Osaka, Japan
Kindai University Hospital
Ōsaka-sayama, Japan
Saitama Cancer Center
Saitama, Japan
Hokkaido University Hospital
Sapporo, Japan
SHOWA Medical University Hospital
Shinagawa-ku, Japan
Keio University Hospital
Shinjuku-ku, Japan
The University of Osaka Hospital
Suita-shi, Japan
Shizuoka Cancer Center
Sunto-gun, Japan
Kanagawa Cancer Center
Yokohama, Japan
Netherlands Cancer Institute
Amsterdam, Netherlands
Amsterdam UMC - location VUmc
Amsterdam, Netherlands
Erasmus MC
Rotterdam, Netherlands
Akershus Universitetssykehus Hf
Lørenskog, Norway
Stavanger University Hospital
Stavanger, Norway
Zanamed Medical Clinic Sp z o o
Lublin, Poland
Mazowiecki Szpital Wojewódzki
Siedlce, Poland
Wojskowy Instytut Medyczny
Warsaw, Poland
Memorial Healthcare International S R L
Bucharest, Romania
Institutul Clinic Fundeni
Bucharest, Romania
S.C Radiotherapy Center Cluj S.R.L
Comuna Floresti, Romania
Centrul de Oncologie Sfantul Nectarie Craiova
Craiova, Romania
S.C. Sigmedical Services SRL
Suceava, Romania
Kyungpook National University Chilgok Hospital
Daegu, South Korea
National Cancer Center
Goyang-si, South Korea
Chonnam National University Hwasun Hospital
Hwasun-gun, South Korea
Gachon University Gil Medical Center
Incheon, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
The Catholic University of Korea, Seoul St. Marys Hospital
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Hospital Universitario de Burgos
Burgos, Spain
Hospital General Universitario de Elche
Elche, Spain
Ico L Hospitalet - Hospital Duran I Reynals
L'Hospitalet de Llobregat, Spain
Hospital General Universitario Gregorio Marañon
Madrid, Spain
Hospital Univ Regional de Málaga Hosp Civil
Málaga, Spain
Complejo Hospitalario Universitario de Orense
Ourense, Spain
Hospital Universitario Central de Asturias
Oviedo, Spain
Hospital Universitario de Navarra
Pamplona, Spain
Hospital Universitario Marques de Valdecilla
Santander, Spain
Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitari i Politecnic La Fé
Valencia, Spain
Sahlgrenska Sjukhuset
Gothenburg, Sweden
Karolinska Universitetssjukhuset Solna
Solna, Sweden
Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
China Medical University Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Hospital
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Altnagelvin Area Hospital
Belfast, United Kingdom
Ninewells Hospital
Dundee, United Kingdom
Barts Hospital
London, United Kingdom
University College London Hospitals
London, United Kingdom
Sarah Cannon Research Institute UK
London, United Kingdom
Charing Cross Hospital
London, United Kingdom
The Christie
Manchester, United Kingdom
Derriford Hospital
Plymouth, United Kingdom
Trial contact
Daiichi Sankyo Contact for Clinical Trial Information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/5/2026.
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