Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)
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About the trial
This phase II MyeloMATCH treatment trial studies how well ASTX727 and venetoclax plus enasidenib works compared to ASTX727 and venetoclax alone for the treatment of older patients with newly diagnosed acute myeloid leukemia (AML) or younger patients who are considered unfit for standard treatment, and who have an abnormal change (mutation) in the IDH2 gene. This gene mutation can cause AML to grow and spread. This trial is being done to see if adding enasidenib to the usual treatment can help more patients with the IDH2 gene get rid of AML. ASTX727 is a fixed-dose formulation of two drugs, cedazuridine and decitabine. Cedazuridine is in a class of medications called cytidine deaminase inhibitors. It prevents the breakdown of decitabine, making it more available in the body so that decitabine will have a greater effect. Decitabine is in a class of medications called hypomethylation agents. It works by helping the bone marrow produce normal blood cells and by killing abnormal cells in the bone marrow. Venetoclax is in a class of medications called B-cell lymphoma-2 (BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein needed for cancer cell survival. Enasidenib works by stopping the growth and spread of tumor cells that have the IDH2 mutation. Giving ASTX727 and venetoclax plus enasidenib may work better in treating AML patients with the IDH2 mutation.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent musi mieć zdiagnozowaną ostrą białaczkę szpikową (AML) z obecną mutacją genu IDH2.
- •Pacjent nie może być poddawany lub planować poddawania się innym eksperymentalnym metodom leczenia.
- •Pacjent musi mieć co najmniej 60 lat LUB być w wieku od 18 lat i nie nadawać się do standardowego leczenia.
- •Pacjent musi mieć dobry ogólny stan zdrowia pozwalający na udział w badaniu (stan sprawności 0-3).
✗ Disqualifies
- •Pacjent nie może być poddawany lub planować poddawania się innym eksperymentalnym metodom leczenia.
- •Pacjent nie może być poddawany leczeniu AML, MDS lub MPN z wyjątkiem niektórych leków przyjmowanych krócej niż miesiąc.
- •Liczba białych krwinek musi być poniżej określonego poziomu przed rozpoczęciem leczenia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (133)
Banner University Medical Center - Tucson
Tucson, United States
University of Arizona Cancer Center-North Campus
Tucson, United States
University of Arkansas for Medical Sciences
Little Rock, United States
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, United States
UCSF Medical Center-Parnassus
San Francisco, United States
Mills Health Center
San Mateo, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, United States
Miami Cancer Institute
Miami, United States
Memorial Hospital West
Pembroke Pines, United States
Augusta University Medical Center
Augusta, United States
Saint Luke's Cancer Institute - Boise
Boise, United States
Kootenai Health - Coeur d'Alene
Coeur d'Alene, United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, United States
Saint Luke's Cancer Institute - Meridian
Meridian, United States
Saint Alphonsus Cancer Care Center-Nampa
Nampa, United States
Saint Luke's Cancer Institute - Nampa
Nampa, United States
Kootenai Clinic Cancer Services - Post Falls
Post Falls, United States
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, United States
Northwestern University
Chicago, United States
University of Illinois
Chicago, United States
University of Chicago Comprehensive Cancer Center
Chicago, United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, United States
Northwestern Medicine Cancer Center Delnor
Geneva, United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, United States
Northwestern Medicine Glenview Outpatient Center
Glenview, United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, United States
Loyola University Medical Center
Maywood, United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, United States
Northwestern Medicine Orland Park
Orland Park, United States
University of Chicago Medicine-Orland Park
Orland Park, United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, United States
UChicago Medicine Northwest Indiana
Crown Point, United States
University of Kansas Clinical Research Center
Fairway, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
The James Graham Brown Cancer Center at University of Louisville
Louisville, United States
UofL Health Medical Center Northeast
Louisville, United States
Our Lady of the Lake Physician Group
Baton Rouge, United States
Our Lady of The Lake
Baton Rouge, United States
MaineHealth Cancer Care and IV Therapy - Brunswick
Brunswick, United States
Mid Coast Hospital
Brunswick, United States
MaineHealth Maine Medical Center - Portland
Portland, United States
MaineHealth Maine Medical Center- Scarborough
Scarborough, United States
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland, United States
Tufts Medical Center
Boston, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, United States
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, United States
Henry Ford Hospital
Detroit, United States
OSF Saint Francis Hospital and Medical Group
Escanaba, United States
Cancer Hematology Centers - Flint
Flint, United States
Genesee Hematology Oncology PC
Flint, United States
Genesys Hurley Cancer Institute
Flint, United States
Allegiance Health
Jackson, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Henry Ford Medical Center-Columbus
Novi, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Henry Ford West Bloomfield Hospital
West Bloomfield, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, United States
Mercy Hospital
Coon Rapids, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Fairview Southdale Hospital
Edina, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Abbott-Northwestern Hospital
Minneapolis, United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, United States
Regions Hospital
Saint Paul, United States
United Hospital
Saint Paul, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Community Hospital of Anaconda
Anaconda, United States
Billings Clinic Cancer Center
Billings, United States
Bozeman Health Deaconess Hospital
Bozeman, United States
Benefis Sletten Cancer Institute
Great Falls, United States
Logan Health Medical Center
Kalispell, United States
Community Medical Center
Missoula, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Cooperman Barnabas Medical Center
Livingston, United States
Monmouth Medical Center
Long Branch, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Rutgers Cancer Institute of New Jersey
New Brunswick, United States
Community Medical Center
Toms River, United States
University of New Mexico Cancer Center
Albuquerque, United States
Roswell Park Cancer Institute
Buffalo, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
University of Rochester
Rochester, United States
Stony Brook University Medical Center
Stony Brook, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
Carolinas Medical Center/Levine Cancer Institute
Charlotte, United States
Duke University Medical Center
Durham, United States
East Carolina University
Greenville, United States
Wake Forest University Health Sciences
Winston-Salem, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Oregon Health and Science University
Portland, United States
Geisinger Medical Center
Danville, United States
Thomas Jefferson University Hospital
Philadelphia, United States
UPMC Hillman Cancer Center
Pittsburgh, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, United States
Rhode Island Hospital
Providence, United States
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, United States
Prisma Health Cancer Institute - Easley
Easley, United States
Prisma Health Cancer Institute - Butternut
Greenville, United States
Prisma Health Cancer Institute - Faris
Greenville, United States
Prisma Health Cancer Institute - Eastside
Greenville, United States
Prisma Health Cancer Institute - Greer
Greer, United States
Prisma Health Cancer Institute - Seneca
Seneca, United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
Swedish Cancer Institute-Edmonds
Edmonds, United States
Swedish Cancer Institute-Issaquah
Issaquah, United States
Swedish Medical Center-First Hill
Seattle, United States
Duluth Clinic Ashland
Ashland, United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, United States
Gundersen Lutheran Medical Center
La Crosse, United States
William S Middleton VA Medical Center
Madison, United States
Medical College of Wisconsin
Milwaukee, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, United States
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, United States
Sheboygan Physicians Group
Sheboygan, United States
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, United States
Marshfield Medical Center - Weston
Weston, United States
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico
San Juan City Hospital
San Juan, Puerto Rico
Trial contact
Site Public Contact
Sharad Khurana
PRINCIPAL_INVESTIGATOR
Site Public Contact
Ankur Varma
PRINCIPAL_INVESTIGATOR
Site Public Contact
Timothy Ferng
PRINCIPAL_INVESTIGATOR
Site Public Contact
Stanislav Ivanov
PRINCIPAL_INVESTIGATOR
Site Public Contact
Firas El Chaer
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Vamsi Kota
PRINCIPAL_INVESTIGATOR
Site Public Contact
Charles W. Drescher
PRINCIPAL_INVESTIGATOR
Site Public Contact
John M. Schallenkamp
PRINCIPAL_INVESTIGATOR
Elie G. Dib
PRINCIPAL_INVESTIGATOR
Site Public Contact
Himachandana Atluri
PRINCIPAL_INVESTIGATOR
Site Public Contact
Noah Birch
PRINCIPAL_INVESTIGATOR
Site Public Contact
Olatoyosi M. Odenike
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
David L. Grinblatt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Stephanie B. Tsai
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Kenneth Byrd
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mohamed M. Hegazi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Harry G. Sequeira Gross
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Pamela Egan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Andreas K. Klein
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Christopher A. Willner
PRINCIPAL_INVESTIGATOR
Site Public Contact
Matthew L. Ryan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
David M. King
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bret E. Friday
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Patrick W. Mellors
PRINCIPAL_INVESTIGATOR
Site Public Contact
Xin Wang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Neil D. Palmisiano
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Charles Foucar
PRINCIPAL_INVESTIGATOR
Site Public Contact
Eunice S. Wang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Paul M. Barr
PRINCIPAL_INVESTIGATOR
Site Public Contact
Suhu Liu
PRINCIPAL_INVESTIGATOR
Site Public Contact
Brittany K. Ragon
PRINCIPAL_INVESTIGATOR
Site Public Contact
Harry P. Erba
PRINCIPAL_INVESTIGATOR
Site Public Contact
Darla K. Liles
PRINCIPAL_INVESTIGATOR
Site Public Contact
Matthew J. Wieduwilt
PRINCIPAL_INVESTIGATOR
Site Public Contact
Manu Pandey
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph J. Vadakara
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lindsay Wilde
PRINCIPAL_INVESTIGATOR
Site Public Contact
Annie P. Im
PRINCIPAL_INVESTIGATOR
Site Public Contact
John L. Reagan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Suzanne R. Fanning
PRINCIPAL_INVESTIGATOR
Site Public Contact
Paul J. Shami
PRINCIPAL_INVESTIGATOR
Site Public Contact
Keri R. Maher
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
David E. Marinier
PRINCIPAL_INVESTIGATOR
Site Public Contact
Christopher D. Fletcher
PRINCIPAL_INVESTIGATOR
Site Public Contact
Guru Subramanian Guru Murthy
PRINCIPAL_INVESTIGATOR
Site Public Contact
Adedayo A. Onitilo
PRINCIPAL_INVESTIGATOR
Luis J. Santos Reyes
PRINCIPAL_INVESTIGATOR
Site Public Contact
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/1/2026.
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