Alpha Radiation Emitters (DaRT) With Chemotherapy for the Treatment of Locally Advanced and Metastatic Pancreatic Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a multi-center clinical study enrolling up to 50 participants. The primary objective of the study is to evaluate the safety of Alpha DaRT in combination with chemotherapy, based on the cumulative incidence rate, severity and outcome of device related AEs. Classification of AEs will be done according to CTCAE V6. The secondary objectives of the study are to: * Assess efficacy of the Alpha DaRT sources in combination with chemotherapy, determined by overall and progression-free survival. * Assess pain control * Assess rate of surgical resection in Cohort 1.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowodiagnozowany rak trzustki - typ niedający się operować (grupa 1) lub rak przerzutowy (grupa 2)
- •Wcześniejsze leczenie chemioterapią mFOLFIRINOX (2-4 cykle)
- •Guz nadający się do wszzczepienia implantu Alpha DaRT
- •Guz o średnicy do 5 cm
- •Stan ogólny pacjenta dobry (wyniku 0-2 w skali ECOG)
- •Oczekiwana długość życia ponad 6 miesięcy
- •Normy laboratoryjne w normie (liczba białych krwinek, płytek krwi, funkcja nerek i wątroby)
- •Wiek co najmniej 18 lat, zgoda na badanie i antykoncepcję przez 3 miesiące
✗ Disqualifies
- •Grupa 1: Rak trzustki możliwy do operacji, chyba że pacjent odmawia operacji
- •Wcześniejsze leczenie raka trzustki (inne niż dozwolona chemioterapia)
- •Alergia na składniki leczenia
- •Przyjmowanie leków tłumiących układ odpornościowy
- •Poważne problemy sercowo-naczyniowe
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 120 Years
- Last updated (source)
- August 25, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (15)
Banner MD Anderson Cancer Center
Gilbert, United States
City of Hope
Goodyear, United States
Honor Health
Scottsdale, United States
Cedars-Sinai
Los Angeles, United States
Advent Health Cancer Institute
Orlando, United States
Emory University
Atlanta, United States
Bassett Healthcare Network
Cooperstown, United States
NYU Langone Health
New York, United States
Lenox hill Hospital
New York, United States
Montefiore Medical Center
The Bronx, United States
Texas Oncology
Houston, United States
Baylor College of Medicine
Houston, United States
University Cancer and Diagnostic
Houston, United States
Jewish General Hospital
Montreal, Canada
Hadassah Ein Kerem
Jerusalem, Israel
Trial contact
Liron Dimnik
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/26/2026.
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