RecruitingPhase III🇵🇱 PolandEN original

Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer

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This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony rak płuca drobnokomórkowy w zaawansowanym stadium.
  • Brak wcześniejszego leczenia systemowego (chemioterapii, itp.) na raka płuca drobnokomórkowego.
  • Posiadanie guza, który można zmierzyć za pomocą badań obrazowych.
  • Ogólny stan zdrowia pozwalający na prowadzenie terapii (ocena wg skali ECOG 0 lub 1).

✗ Disqualifies

  • Rak płuca drobnokomórkowy z dodatkowymi typami komórek rakowych.
  • Otrzymanie niektórych leków lub terapii (np. radioterapii całego mózgu) w ciągu ostatnich 2 tygodni.
  • Otrzymanie małych cząsteczkowych leków w ciągu ostatnich 2 tygodni.
  • Otrzymanie radioterapii poza klatką piersiową w ciągu ostatnich 2 tygodni (poza niektórymi wyjątkami dotyczącymi mózgu i kości).

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 1, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (211)

ACRC Arizona Clinical Research Center

Tucson, United States

Clermont Oncology Center

Clermont, United States

Cancer Care Centers of Brevard, Inc

Palm Bay, United States

Northside Hospital Atlanta

Atlanta, United States

Illinois Cancer Specialists

Niles, United States

Fort Wayne Medical Oncology and Hematology, Inc

Fort Wayne, United States

McFarland Clinic

Ames, United States

Helen G. Nassif Community Cancer Center

Cedar Rapids, United States

Baptist Health Hardin Cancer Center

Elizabethtown, United States

Frederick Health Hospital- James M Stockman Cancer Institute

Frederick, United States

Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center

Burlington, United States

Baptist Cancer Center

Southaven, United States

Washington University School of Medicine

St Louis, United States

Nebraska Hematology-Oncology (NHO)

Lincoln, United States

Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center

New York, United States

White Plains Hospital

White Plains, United States

Cleveland Clinic - Akron General Hematology & Oncology

Akron, United States

Cleveland Clinic Mercy Hospital Cancer Center

Canton, United States

The Christ Hospital Cancer Center

Cincinnati, United States

University Hospitals Cleveland Medical Center

Cleveland, United States

The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion

Cleveland, United States

Cleveland Clinic Foundation

Cleveland, United States

Kettering Medical Center

Kettering, United States

Cleveland Clinic - Hillcrest Hospital

Mayfield Heights, United States

St. Luke's Physician Group - St. Luke's Cancer Care Associates

Fountain Hill, United States

West Cancer Center & Research Institute

Germantown, United States

University of Tennessee Medical Center

Knoxville, United States

The University of Texas MD Anderson Cancer Center

Houston, United States

Millennium Research and Clinical Development, LLC

Houston, United States

Texas Oncology Cancer Center

Sugar Land, United States

Virginia Cancer Specialists

Fairfax, United States

Hematology Oncology Associates of Fredericksburg, Inc.

Fredericksburg, United States

Virginia Commonwealth University School of Medicine

Richmond, United States

Shenandoah Oncology

Winchester, United States

Calvary Mater Newcastle

Waratah, Australia

Cancer Care Wollongong Pty Limited

Wollongong, Australia

Cairns Hospital

Cairns, Australia

Icon Cancer Centre Kurralta Park

Kurralta Park, Australia

The Queen Elizabeth Hospital

Woodville, Australia

Peninsula & South Eastern Haematology and Oncology Group

Frankston, Australia

Olivia Newton-John Cancer Wellness & Research centre

Heidelberg, Australia

Western Health Sunshine Hospital

St Albans, Australia

Cairns Hospital

Cairns, Australia

Sir Charles Gairdner Hospital (SCGH)

Nedlands, Australia

Royal North Shore Hospital

Saint Leonards, Australia

Jilin Cancer Hospital

Changchun, China

Affiliated Hospital of Hebei University

Baoding, China

Beijing Friendship Hospital, Capital Medical University

Beijing, China

Peking Union Medical College Hospital

Beijing, China

Beijing Chest Hospital,Capital Medical University

Beijing, China

The First Affiliated Hospital of Bengbu Medical College

Bengbu, China

Fujian Provincial Cancer Hospital

Fuzhou, China

Guangdong General Hospital

Guangzhou, China

Zhejiang Medical University, Zhejiang Cancer Hospital

Hangzhou, China

Harbin Medical University Cancer Hospital

Ha’erbin, China

Cancer Hospital Chinese Academy of Medical Sciences

Hebei, China

Anhui Provincial Hospital

Hefei, China

Jiamusi Cancer Hospital

Jiamusi, China

Shandong University - Jinan Central Hospital

Jinan, China

Shandong Cancer Hospital and Institute

Jinan, China

Yunnan Provincial Cancer Hospital

Kunming, China

Linyi Cancer Hospital

Linyi, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

Jiangsu Peoples Hospital

Nanjing, China

Guangxi Tumour Hospital

Nanning, China

Shanghai Chest Hospital

Shanghai, China

Fudan University - Shanghai Cancer Center (FUSCC)

Shanghai, China

Cancer Hospital of Shantou University Medical College

Shantou, China

The First Affiliated Hospital of Soochow University

Suzhou, China

Shanxi Provincial Tumor Hospital (Shanxi Oncology Hospital)

Taiyuan, China

Chongqing University Three Gorges Hospital

Wanzhou, China

The First Affiliated Hospital Of Wenzhou Medical University

Wenzhou, China

Union Hospital Tongji Medical College of Huazhong University of Science and Technology (HUST)

Wuhan, China

Zhongnan Hospital of Wuhan University

Wuhan, China

Xiangyang Central Hospital

Xiangyang, China

The First Affiliated Hospital of Henan Medical University

Xinxiang, China

Northern Jiangsu Peoples Hospital (NJPH)

Yangzhou, China

Taizhou Hospital of Zhejiang Province

Zhejiang, China

Henan Cancer Hospital (Affiliated Cancer Hospital of Zhengzhou University)

Zhengzhou, China

Centre Hospitalier Universitaire d'Angers (CHU Angers)

Angers, France

Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

Bordeaux, France

CHU de Caen

Caen, France

Institut Curie - Centre de Recherche

Paris, France

CHU de Rennes, Hopital de Pontchaillou

Rennes, France

Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau

Saint-Herblain, France

Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hopital Sainte Musse

Toulon, France

Evangelische Lungenklinik Berlin

Berlin, Germany

Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK)

Berlin, Germany

Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling

Bonn, Germany

Klinikum Chemnitz Gmbh

Chemnitz, Germany

Klinikum Esslingen GmbH

Esslingen am Neckar, Germany

Asklepios Fachkliniken Muenchen Gauting

Gauting, Germany

SRH Wald-Kliniken Gera GmbH

Gera, Germany

LungenClinic Grosshansdorf GmbH

Großhansdorf, Germany

Krankenhaus Martha-Maria Halle-Doelau gGmbH

Halle, Germany

Klinikum Kempten-Oberallgau gGmbH

Kempten, Germany

Universitaetsklinikum Schleswig-Holstein (UKSH) - Campus Luebeck

Lübeck, Germany

University Medical Center of Johannes Gutenberg-University Mainz

Mainz, Germany

Staedtisches Klinikum Muenchen Bogenhausen

München, Germany

MVZ for oncology and hematology Rhein-Kreis Neuss GmbH

Neuss, Germany

Klinikum Nuernberg Nord

Nuremberg, Germany

Helios Klinikum Wuppertal-Universitaet Witten-Herdecke

Wuppertal, Germany

Azienda Ospedaliera San Giuseppe Moscati

Avellino, Italy

Centro di Riferimento Oncologico

Aviano, Italy

Azienda Socio Sanitaria Territoriale di Cremona

Cremona, Italy

Ospedale San Luca

Lucca, Italy

IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST)

Meldola, Italy

Universita Degli Studi Di Milano-Bicocca - Azienda Ospedaliera San Gerardo Di Monza

Monza, Italy

Casa Di Cura Polispecialistica Dott Pederzoli

Peschiera del Garda, Italy

Tokyo Metropolitan Komagome Hospital

Bunkyō City, Japan

National Cancer Center Hospital

Chūōku, Japan

National Hospital Organization Kyushu Cancer Center

Fukuoka, Japan

Saitama Medical University International Medical Center

Hidaka, Japan

National Hospital Organization Himeji Medical Center

Himeji, Japan

National Hospital Organization Iwakuni Clinical Center

Iwakuni, Japan

Kurume University Hospital

Kurume, Japan

Matsusaka Municipal Hospital

Matsusaka, Japan

National Hospital Organization Shikoku Cancer Center

Matsuyama, Japan

Sendai Kousei Hospital

Miyagi, Japan

National Hospital Organization Nagoya Medical Center

Nagoya, Japan

Niigata Cancer Center Hospital

Niigata, Japan

Okayama University Hospital

Okayama, Japan

Osaka Prefectural Hospital Organization Osaka International Cancer Institute

Osaka, Japan

NHO Kinki Chuo Chest Medical Center

Sakai, Japan

Shibukawa Medical Center

Shibukawa, Japan

National Hospital Organization Yamaguchi-Ube Medical Center

Ube, Japan

Yokohama Municipal Citizen's Hospital

Yokohama, Japan

Kanagawa Cancer Center

Yokohama, Japan

Uniwersyteckie Centrum Kliniczne

Gdansk, Poland

Pratia Onkologia Katowice

Katowice, Poland

KOMED Roman Karaszewski I Wspolnicy Spolka Jawna

Konin, Poland

FutureMeds Krakow

Krakow, Poland

Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie

Lublin, Poland

Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie

Olsztyn, Poland

Wielkopolskie Centrum Pulmonologii i Tarakochirurgii

Poznan, Poland

Pratia S.A. , Pratia Poznan

Poznan, Poland

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu

Przemyśl, Poland

Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy

Warsaw, Poland

Pratia Wroclaw Onkologia

Wroclaw, Poland

SC Oncopremium Team SRL

Baia Mare, Romania

Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti (IOB)

Bucharest, Romania

Coltea Clinical Hospital

Bucharest, Romania

Cardiomed

Cluj-Napoca, Romania

Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center)

Craiova, Romania

Centrul de Oncologie Euroclinic srl

Iași, Romania

City Hospital Onesti

Onești, Romania

Oncocenter Oncologie Clinica S.R.L

Timișoara, Romania

Oncomed

Timișoara, Romania

Korea University Guro Hospital

Seoul, South Korea

National Cancer Center

Goyang-si, South Korea

The Catholic University Of Korea, St. Vincent's Hospital

Suwon, South Korea

Ajou University Hospital

Suwon, South Korea

Gyeongsang National University Hospital (GNUH)

Jinju, South Korea

Gachon University Gil Medical Center

Incheon, South Korea

Chungbuk National University Hospital

Cheongju-si, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center (AMC)

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Hospital Universitario de Badajoz

Badajoz, Spain

Parc de Salut Mar - Hospital del Mar

Barcelona, Spain

UOMI Cancer Center-Clinica Tres Torres

Barcelona, Spain

Hospital Universitario Vall d'Hebron

Barcelona, Spain

Consorcio Hospitalario Provincial de Castellon

Castellon, Spain

Hospital General Universitario Gregorio Maranon (HGUGM)

Madrid, Spain

Clinica MD Anderson International

Madrid, Spain

Hospital Regional Universitario de Malaga

Málaga, Spain

Universidad de Sevilla - Hospital Universitario Virgen Macarena

Seville, Spain

Hospital Universitario Nuestra Senora De Valme

Seville, Spain

Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)

Valencia, Spain

Hospital Alvaro Cunqueiro

Vigo, Spain

Hospital Clinico Universitario Lozano Blesa de Zaragoza

Zaragoza, Spain

Acibadem Adana Hospital

Adana, Turkey (Türkiye)

Seyhan Medical Park Hospital

Adana, Turkey (Türkiye)

Baskent University Adana Turgut Noyan Application and Research Center

Adana, Turkey (Türkiye)

Ankara Etlik City Hospital

Ankara, Turkey (Türkiye)

Gulhane Training and Research Hospital

Ankara, Turkey (Türkiye)

Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital

Ankara, Turkey (Türkiye)

Hacettepe University Medical Faculty Hospital

Ankara, Turkey (Türkiye)

Memorial Ankara Hospital

Ankara, Turkey (Türkiye)

Gazi University, Medical Faculty Hospital

Ankara, Turkey (Türkiye)

Liv Hospital Ankara

Ankara, Turkey (Türkiye)

Ankara Bilkent City Hospital

Ankara, Turkey (Türkiye)

Akdeniz University Hospital

Antalya, Turkey (Türkiye)

Trakya University Faculty of Medicine

Edirne, Turkey (Türkiye)

Koc Universitesi Hastanesi (Koc University Hospital)

Istanbul, Turkey (Türkiye)

Medical Park Florya Hospital

Istanbul, Turkey (Türkiye)

Yeditepe University Kosuyolu Hospital

Istanbul, Turkey (Türkiye)

Marmara University Pendik Training and Research Hospital

Istanbul, Turkey (Türkiye)

Goztepe Prof. Dr. Suleyman Yalcin City Hospital

Istanbul, Turkey (Türkiye)

Medical Point Izmir Hospital

Izmir, Turkey (Türkiye)

Kocaeli University Medical Faculty Hospital

Kocaeli, Turkey (Türkiye)

Ankara University Medical Faculty Hospital

Mamak, Turkey (Türkiye)

Sakarya University Training and Research Hospital

Sakarya, Turkey (Türkiye)

The Christie NHS Foundation Trust

Manchester, United Kingdom

Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust

Chelsea, United Kingdom

Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust

Sutton, United Kingdom

Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust

Huddersfield, United Kingdom

Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals NHS Foundation Trust

Newcastle upon Tyne, United Kingdom

Nottingham University Hospitals NHS Trust - Nottingham City Hospital

Nottingham, United Kingdom

Churchill Hospital - Oxford University Hospitals NHS Foundation Trust

Oxford, United Kingdom

Ninewells Hospital and Medical School - Tayside Health Board

Dundee, United Kingdom

Torbay and South Devon NHS Foundation Trust

Torquay, United Kingdom

Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust

Stoke-on-Trent, United Kingdom

Velindre NHS Trust, Velindre Cancer Centre

Cardiff, United Kingdom

New Cross Hospital

Wolverhampton, United Kingdom

Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust

Cambridge, United Kingdom

Hull University Teaching Hospitals NHS Trust

Cottingham, United Kingdom

Royal Devon and Exeter Hospital, Royal Devon University Healthcare NHS Foundation Trust

Exeter, United Kingdom

St James's University Hospital - Leeds Teaching Hospitals NHS Trust

Leeds, United Kingdom

Guy's Hospital - Guy's & St Thomas' NHS Foundation Trust

London, United Kingdom

Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust

Preston, United Kingdom

Trial contact

BioNTech clinical trials patient information

Contact information from ClinicalTrials.gov. Contact in English.

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.