Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for the treatment of participants with previously untreated extensive-stage small-cell lung cancer (ES-SCLC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak płuca drobnokomórkowy w zaawansowanym stadium.
- •Brak wcześniejszego leczenia systemowego (chemioterapii, itp.) na raka płuca drobnokomórkowego.
- •Posiadanie guza, który można zmierzyć za pomocą badań obrazowych.
- •Ogólny stan zdrowia pozwalający na prowadzenie terapii (ocena wg skali ECOG 0 lub 1).
✗ Disqualifies
- •Rak płuca drobnokomórkowy z dodatkowymi typami komórek rakowych.
- •Otrzymanie niektórych leków lub terapii (np. radioterapii całego mózgu) w ciągu ostatnich 2 tygodni.
- •Otrzymanie małych cząsteczkowych leków w ciągu ostatnich 2 tygodni.
- •Otrzymanie radioterapii poza klatką piersiową w ciągu ostatnich 2 tygodni (poza niektórymi wyjątkami dotyczącymi mózgu i kości).
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (211)
ACRC Arizona Clinical Research Center
Tucson, United States
Clermont Oncology Center
Clermont, United States
Cancer Care Centers of Brevard, Inc
Palm Bay, United States
Northside Hospital Atlanta
Atlanta, United States
Illinois Cancer Specialists
Niles, United States
Fort Wayne Medical Oncology and Hematology, Inc
Fort Wayne, United States
McFarland Clinic
Ames, United States
Helen G. Nassif Community Cancer Center
Cedar Rapids, United States
Baptist Health Hardin Cancer Center
Elizabethtown, United States
Frederick Health Hospital- James M Stockman Cancer Institute
Frederick, United States
Beth Israel Lahey Health - Lahey Hospital & Medical Center (LHMC), Lahey Clinic Medical Center
Burlington, United States
Baptist Cancer Center
Southaven, United States
Washington University School of Medicine
St Louis, United States
Nebraska Hematology-Oncology (NHO)
Lincoln, United States
Cornell University - NewYork-Presbyterian/Weill Cornell Medical Center
New York, United States
White Plains Hospital
White Plains, United States
Cleveland Clinic - Akron General Hematology & Oncology
Akron, United States
Cleveland Clinic Mercy Hospital Cancer Center
Canton, United States
The Christ Hospital Cancer Center
Cincinnati, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
The Cleveland Clinic Cancer Center at Fairview Hospital, Moll Pavilion
Cleveland, United States
Cleveland Clinic Foundation
Cleveland, United States
Kettering Medical Center
Kettering, United States
Cleveland Clinic - Hillcrest Hospital
Mayfield Heights, United States
St. Luke's Physician Group - St. Luke's Cancer Care Associates
Fountain Hill, United States
West Cancer Center & Research Institute
Germantown, United States
University of Tennessee Medical Center
Knoxville, United States
The University of Texas MD Anderson Cancer Center
Houston, United States
Millennium Research and Clinical Development, LLC
Houston, United States
Texas Oncology Cancer Center
Sugar Land, United States
Virginia Cancer Specialists
Fairfax, United States
Hematology Oncology Associates of Fredericksburg, Inc.
Fredericksburg, United States
Virginia Commonwealth University School of Medicine
Richmond, United States
Shenandoah Oncology
Winchester, United States
Calvary Mater Newcastle
Waratah, Australia
Cancer Care Wollongong Pty Limited
Wollongong, Australia
Cairns Hospital
Cairns, Australia
Icon Cancer Centre Kurralta Park
Kurralta Park, Australia
The Queen Elizabeth Hospital
Woodville, Australia
Peninsula & South Eastern Haematology and Oncology Group
Frankston, Australia
Olivia Newton-John Cancer Wellness & Research centre
Heidelberg, Australia
Western Health Sunshine Hospital
St Albans, Australia
Cairns Hospital
Cairns, Australia
Sir Charles Gairdner Hospital (SCGH)
Nedlands, Australia
Royal North Shore Hospital
Saint Leonards, Australia
Jilin Cancer Hospital
Changchun, China
Affiliated Hospital of Hebei University
Baoding, China
Beijing Friendship Hospital, Capital Medical University
Beijing, China
Peking Union Medical College Hospital
Beijing, China
Beijing Chest Hospital,Capital Medical University
Beijing, China
The First Affiliated Hospital of Bengbu Medical College
Bengbu, China
Fujian Provincial Cancer Hospital
Fuzhou, China
Guangdong General Hospital
Guangzhou, China
Zhejiang Medical University, Zhejiang Cancer Hospital
Hangzhou, China
Harbin Medical University Cancer Hospital
Ha’erbin, China
Cancer Hospital Chinese Academy of Medical Sciences
Hebei, China
Anhui Provincial Hospital
Hefei, China
Jiamusi Cancer Hospital
Jiamusi, China
Shandong University - Jinan Central Hospital
Jinan, China
Shandong Cancer Hospital and Institute
Jinan, China
Yunnan Provincial Cancer Hospital
Kunming, China
Linyi Cancer Hospital
Linyi, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Jiangsu Peoples Hospital
Nanjing, China
Guangxi Tumour Hospital
Nanning, China
Shanghai Chest Hospital
Shanghai, China
Fudan University - Shanghai Cancer Center (FUSCC)
Shanghai, China
Cancer Hospital of Shantou University Medical College
Shantou, China
The First Affiliated Hospital of Soochow University
Suzhou, China
Shanxi Provincial Tumor Hospital (Shanxi Oncology Hospital)
Taiyuan, China
Chongqing University Three Gorges Hospital
Wanzhou, China
The First Affiliated Hospital Of Wenzhou Medical University
Wenzhou, China
Union Hospital Tongji Medical College of Huazhong University of Science and Technology (HUST)
Wuhan, China
Zhongnan Hospital of Wuhan University
Wuhan, China
Xiangyang Central Hospital
Xiangyang, China
The First Affiliated Hospital of Henan Medical University
Xinxiang, China
Northern Jiangsu Peoples Hospital (NJPH)
Yangzhou, China
Taizhou Hospital of Zhejiang Province
Zhejiang, China
Henan Cancer Hospital (Affiliated Cancer Hospital of Zhengzhou University)
Zhengzhou, China
Centre Hospitalier Universitaire d'Angers (CHU Angers)
Angers, France
Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest
Bordeaux, France
CHU de Caen
Caen, France
Institut Curie - Centre de Recherche
Paris, France
CHU de Rennes, Hopital de Pontchaillou
Rennes, France
Institut de Cancerologie de l'Ouest (ICO)- CRLCC Rene Gauducheau
Saint-Herblain, France
Centre Hospitalier Intercommunal Toulon La Seyne Sur Mer (C.H.I.T.S) - Hopital Sainte Musse
Toulon, France
Evangelische Lungenklinik Berlin
Berlin, Germany
Charite - Universitaetsmedizin Berlin - Campus Virchow-Klinikum (CVK)
Berlin, Germany
Praxiskooperation Bonn-Euskirchen-Rheinbach-Wesseling
Bonn, Germany
Klinikum Chemnitz Gmbh
Chemnitz, Germany
Klinikum Esslingen GmbH
Esslingen am Neckar, Germany
Asklepios Fachkliniken Muenchen Gauting
Gauting, Germany
SRH Wald-Kliniken Gera GmbH
Gera, Germany
LungenClinic Grosshansdorf GmbH
Großhansdorf, Germany
Krankenhaus Martha-Maria Halle-Doelau gGmbH
Halle, Germany
Klinikum Kempten-Oberallgau gGmbH
Kempten, Germany
Universitaetsklinikum Schleswig-Holstein (UKSH) - Campus Luebeck
Lübeck, Germany
University Medical Center of Johannes Gutenberg-University Mainz
Mainz, Germany
Staedtisches Klinikum Muenchen Bogenhausen
München, Germany
MVZ for oncology and hematology Rhein-Kreis Neuss GmbH
Neuss, Germany
Klinikum Nuernberg Nord
Nuremberg, Germany
Helios Klinikum Wuppertal-Universitaet Witten-Herdecke
Wuppertal, Germany
Azienda Ospedaliera San Giuseppe Moscati
Avellino, Italy
Centro di Riferimento Oncologico
Aviano, Italy
Azienda Socio Sanitaria Territoriale di Cremona
Cremona, Italy
Ospedale San Luca
Lucca, Italy
IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" (IRST)
Meldola, Italy
Universita Degli Studi Di Milano-Bicocca - Azienda Ospedaliera San Gerardo Di Monza
Monza, Italy
Casa Di Cura Polispecialistica Dott Pederzoli
Peschiera del Garda, Italy
Tokyo Metropolitan Komagome Hospital
Bunkyō City, Japan
National Cancer Center Hospital
Chūōku, Japan
National Hospital Organization Kyushu Cancer Center
Fukuoka, Japan
Saitama Medical University International Medical Center
Hidaka, Japan
National Hospital Organization Himeji Medical Center
Himeji, Japan
National Hospital Organization Iwakuni Clinical Center
Iwakuni, Japan
Kurume University Hospital
Kurume, Japan
Matsusaka Municipal Hospital
Matsusaka, Japan
National Hospital Organization Shikoku Cancer Center
Matsuyama, Japan
Sendai Kousei Hospital
Miyagi, Japan
National Hospital Organization Nagoya Medical Center
Nagoya, Japan
Niigata Cancer Center Hospital
Niigata, Japan
Okayama University Hospital
Okayama, Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute
Osaka, Japan
NHO Kinki Chuo Chest Medical Center
Sakai, Japan
Shibukawa Medical Center
Shibukawa, Japan
National Hospital Organization Yamaguchi-Ube Medical Center
Ube, Japan
Yokohama Municipal Citizen's Hospital
Yokohama, Japan
Kanagawa Cancer Center
Yokohama, Japan
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Pratia Onkologia Katowice
Katowice, Poland
KOMED Roman Karaszewski I Wspolnicy Spolka Jawna
Konin, Poland
FutureMeds Krakow
Krakow, Poland
Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie
Lublin, Poland
Warminsko Mazurskie Centrum Chorob Pluc w Olsztynie
Olsztyn, Poland
Wielkopolskie Centrum Pulmonologii i Tarakochirurgii
Poznan, Poland
Pratia S.A. , Pratia Poznan
Poznan, Poland
Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu
Przemyśl, Poland
Wojskowy Instytut Medyczny Panstwowy Instytut Badawczy
Warsaw, Poland
Pratia Wroclaw Onkologia
Wroclaw, Poland
SC Oncopremium Team SRL
Baia Mare, Romania
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti (IOB)
Bucharest, Romania
Coltea Clinical Hospital
Bucharest, Romania
Cardiomed
Cluj-Napoca, Romania
Centrul de Oncologie Sf. Nectarie S.R.L (Sf Nectarie Oncology Center)
Craiova, Romania
Centrul de Oncologie Euroclinic srl
Iași, Romania
City Hospital Onesti
Onești, Romania
Oncocenter Oncologie Clinica S.R.L
Timișoara, Romania
Oncomed
Timișoara, Romania
Korea University Guro Hospital
Seoul, South Korea
National Cancer Center
Goyang-si, South Korea
The Catholic University Of Korea, St. Vincent's Hospital
Suwon, South Korea
Ajou University Hospital
Suwon, South Korea
Gyeongsang National University Hospital (GNUH)
Jinju, South Korea
Gachon University Gil Medical Center
Incheon, South Korea
Chungbuk National University Hospital
Cheongju-si, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center (AMC)
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Hospital Universitario de Badajoz
Badajoz, Spain
Parc de Salut Mar - Hospital del Mar
Barcelona, Spain
UOMI Cancer Center-Clinica Tres Torres
Barcelona, Spain
Hospital Universitario Vall d'Hebron
Barcelona, Spain
Consorcio Hospitalario Provincial de Castellon
Castellon, Spain
Hospital General Universitario Gregorio Maranon (HGUGM)
Madrid, Spain
Clinica MD Anderson International
Madrid, Spain
Hospital Regional Universitario de Malaga
Málaga, Spain
Universidad de Sevilla - Hospital Universitario Virgen Macarena
Seville, Spain
Hospital Universitario Nuestra Senora De Valme
Seville, Spain
Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)
Valencia, Spain
Hospital Alvaro Cunqueiro
Vigo, Spain
Hospital Clinico Universitario Lozano Blesa de Zaragoza
Zaragoza, Spain
Acibadem Adana Hospital
Adana, Turkey (Türkiye)
Seyhan Medical Park Hospital
Adana, Turkey (Türkiye)
Baskent University Adana Turgut Noyan Application and Research Center
Adana, Turkey (Türkiye)
Ankara Etlik City Hospital
Ankara, Turkey (Türkiye)
Gulhane Training and Research Hospital
Ankara, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ankara, Turkey (Türkiye)
Hacettepe University Medical Faculty Hospital
Ankara, Turkey (Türkiye)
Memorial Ankara Hospital
Ankara, Turkey (Türkiye)
Gazi University, Medical Faculty Hospital
Ankara, Turkey (Türkiye)
Liv Hospital Ankara
Ankara, Turkey (Türkiye)
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)
Akdeniz University Hospital
Antalya, Turkey (Türkiye)
Trakya University Faculty of Medicine
Edirne, Turkey (Türkiye)
Koc Universitesi Hastanesi (Koc University Hospital)
Istanbul, Turkey (Türkiye)
Medical Park Florya Hospital
Istanbul, Turkey (Türkiye)
Yeditepe University Kosuyolu Hospital
Istanbul, Turkey (Türkiye)
Marmara University Pendik Training and Research Hospital
Istanbul, Turkey (Türkiye)
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul, Turkey (Türkiye)
Medical Point Izmir Hospital
Izmir, Turkey (Türkiye)
Kocaeli University Medical Faculty Hospital
Kocaeli, Turkey (Türkiye)
Ankara University Medical Faculty Hospital
Mamak, Turkey (Türkiye)
Sakarya University Training and Research Hospital
Sakarya, Turkey (Türkiye)
The Christie NHS Foundation Trust
Manchester, United Kingdom
Royal Marsden Hospital (RMH) - Royal Marsden NHS Foundation Trust
Chelsea, United Kingdom
Royal Marsden Hospital (Sutton) - Royal Marsden NHS Foundation Trust
Sutton, United Kingdom
Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust
Huddersfield, United Kingdom
Northern Centre for Cancer Care - The Newcastle Upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
Nottingham University Hospitals NHS Trust - Nottingham City Hospital
Nottingham, United Kingdom
Churchill Hospital - Oxford University Hospitals NHS Foundation Trust
Oxford, United Kingdom
Ninewells Hospital and Medical School - Tayside Health Board
Dundee, United Kingdom
Torbay and South Devon NHS Foundation Trust
Torquay, United Kingdom
Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, United Kingdom
Velindre NHS Trust, Velindre Cancer Centre
Cardiff, United Kingdom
New Cross Hospital
Wolverhampton, United Kingdom
Addenbrooke's Hospital - Cambridge University Hospitals NHS Foundation Trust
Cambridge, United Kingdom
Hull University Teaching Hospitals NHS Trust
Cottingham, United Kingdom
Royal Devon and Exeter Hospital, Royal Devon University Healthcare NHS Foundation Trust
Exeter, United Kingdom
St James's University Hospital - Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
Guy's Hospital - Guy's & St Thomas' NHS Foundation Trust
London, United Kingdom
Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust
Preston, United Kingdom
Trial contact
BioNTech clinical trials patient information
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.