Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

Phase I: Characterize safety and tolerability of ECI830 as a single agent and in combination with ribociclib and fulvestrant. Identify dose range for optimization/recommended dose for future studies. Phase II: Assess the anti-tumor activity of ECI830 in combination with ribociclib and fulvestrant in patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Osoby powyżej 18. roku życia.
  • Pacjenci z zaawansowanym rakiem piersi (HR+/HER2-) u których choroba postąpiła pomimo wcześniejszego leczenia.
  • Pacjenci z zaawansowanym lub rozsianym rakiem potwierdzonym badaniami, z pewnym typem amplifikacji genu CCNE1.
  • W fazie II: Pacjenci z zaawansowanym rakiem piersi (HR+/HER2-) u których choroba postąpiła po leczeniu inhibitory aromatazy lub tamoksyfenem w połączeniu z inhibitorem CDK4/6.

✗ Disqualifies

  • Osoby, które wcześniej otrzymywały inhibitor CDK2.
  • Pacjenci z niewystarczającą funkcją szpiku kostnego lub narządów.
  • Osoby z poważnymi, niekontrolowanymi chorobami serca.
  • Osoby z objawowymi przerzutami do mózgu lub wymagającymi leczenia w ciągu ostatnich 2 tygodni.
  • W leczeniu skojarzonym: Pacjenci z objawową chorobą narządów wewnętrznych.
  • Kobiety w ciąży lub karmiące piersią, lub te, które nie chcą stosować skutecznej antykoncepcji.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Maximum age
100 Years
Last updated (source)
July 13, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (33)

University of California LA

Los Angeles, United States

Florida Cancer Specialists

Fort Myers, United States

Dana Farber Cancer Institute

Boston, United States

WA Uni School Of Med

St Louis, United States

Memorial Sloan Kettering

New York, United States

SCRI Oncology Partners

Nashville, United States

MD Anderson Cancer Center Uni of Te

Houston, United States

Fred Hutch Cancer Research

Seattle, United States

Novartis Investigative Site

Clayton, Australia

Novartis Investigative Site

Melbourne, Australia

Novartis Investigative Site

Toronto, Canada

Novartis Investigative Site

Montreal, Canada

Novartis Investigative Site

Nanjing, China

Novartis Investigative Site

Xian, China

Novartis Investigative Site

Brno, Czechia

Novartis Investigative Site

Copenhagen, Denmark

Novartis Investigative Site

Odense C, Denmark

Novartis Investigative Site

Bordeaux, France

Novartis Investigative Site

Saint-Herblain, France

Novartis Investigative Site

Freiburg im Breisgau, Germany

Novartis Investigative Site

Heidelberg, Germany

Novartis Investigative Site

Ulm, Germany

Novartis Investigative Site

Haifa, Israel

Novartis Investigative Site

Tel Aviv, Israel

Novartis Investigative Site

Modena, Italy

Novartis Investigative Site

Milan, Italy

Novartis Investigative Site

Chuo Ku, Japan

Novartis Investigative Site

Singapore, Singapore

Novartis Investigative Site

Seoul, South Korea

Novartis Investigative Site

Barcelona, Spain

Novartis Investigative Site

Barcelona, Spain

Novartis Investigative Site

Tainan, Taiwan

Novartis Investigative Site

London, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/1/2026.

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