A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are investigating new treatments for untreated advanced non-small cell lung cancer (NSCLC), which is the most common form of lung cancer and lung cancer that has spread beyond surgical removal. Standard treatments include immunotherapy, such as pembrolizumab, and chemotherapy. This study aims to determine the effectiveness of adding other treatments, including the human epidermal growth factor receptor 3-directed antibody-drug conjugate (HER3-DXd) patritumab deruxtecan, to pembrolizumab, with or without chemotherapy. The primary goals are to assess safety and efficacy of the treatments.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony nowotok płuca w stadium IV (zaawansowany, rozprzestrzeniony)
- •Ogólny stan zdrowia oceniony na 0 lub 1 (pacjent jest w dobrym stanie do podjęcia leczenia)
- •Dostęp do próbki guza z poprzedniego badania lub świeża biopsja
- •Pacjenci z HIV muszą mieć kontrolowaną chorobę pod leczeniem
✗ Disqualifies
- •Rak płuca drobnokomórkowy lub nowotwór mieszany zawierający komórki drobnokomórkowe
- •Niektóre rzadkie mutacje genetyczne guza (EGFR, ALK, ROS1)
- •Pacjenci z HIV i historią poważnych powikłań (Kaposi, choroba Castelmana)
- •Poważne problemy z płucami lub zapalenia autoimmunologiczne obejmujące płuca
- •Przerzuty do opon mózgowych
- •Udar serca w ciągu ostatnich 6 miesięcy
- •Ciężka niewydolność serca (klasa III-IV)
- •Niekontrolowana choroba naczyniowa serca
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (41)
University of Kentucky ( Site 0019)
Lexington, United States
MedStar Franklin Square Medical Center ( Site 0033)
Baltimore, United States
Sanford Fargo Medical Center ( Site 0039)
Fargo, United States
Abramson Cancer Center ( Site 0010)
Philadelphia, United States
Sanford Cancer Center ( Site 0038)
Sioux Falls, United States
Centro de Estudios Clínicos SAGA ( Site 0162)
Santiago, Chile
FALP ( Site 0161)
Santiago, Chile
Bradfordhill ( Site 0160)
Santiago, Chile
THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 0204)
Athens, Greece
European Interbalkan Medical Center-Oncology Department ( Site 0205)
Thessaloniki, Greece
Petz Aladar Egyetemi Oktato Korhaz ( Site 0062)
Győr, Hungary
Jasz-Nagykun-Szolnok Megyei Hetenyi Gyula Korhaz-Rendelointezet ( Site 0061)
Szolnok, Hungary
Országos Korányi Pulmonológiai Intézet ( Site 0060)
Budapest, Hungary
Rambam Health Care Campus ( Site 0076)
Haifa, Israel
Shaare Zedek Medical Center ( Site 0075)
Jerusalem, Israel
Meir Medical Center ( Site 0071)
Kfar Saba, Israel
Rabin Medical Center ( Site 0074)
Petah Tikva, Israel
Sheba Medical Center ( Site 0070)
Ramat Gan, Israel
Sourasky Medical Center ( Site 0077)
Tel Aviv, Israel
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0175)
Milan, Italy
IRCCS Ospedale San Raffaele ( Site 0171)
Milan, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0174)
Roma, Italy
Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 0153)
Poznan, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 0151)
Warsaw, Poland
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150)
Gdansk, Poland
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0152)
Koszalin, Poland
Institut Català d'Oncologia - L'Hospitalet ( Site 0090)
L'Hospitalet de Llobregat, Spain
HOSPITAL CLÍNIC DE BARCELONA ( Site 0092)
Barcelona, Spain
Hospital Universitario Quiron Madrid ( Site 0091)
Madrid, Spain
Changhua Christian Hospital ( Site 0181)
Changhua, Taiwan
Taipei Medical University Hospital ( Site 0180)
Taipei, Taiwan
Chang Gung Medical Foundation-Linkou Branch ( Site 0182)
Taoyuan, Taiwan
Baskent University Dr. Turgut Noyan Research and Training Center ( Site 0141)
Adana, Turkey (Türkiye)
Hacettepe Universite Hastaneleri ( Site 0140)
Ankara, Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 0142)
Ankara, Turkey (Türkiye)
CNE CC of Oncology Hematol ( Site 0130)
Cherkasy, Ukraine
Municipal Enterprise "Bukovinian сlinical oncology сenter" ( Site 0136)
Chernivtsi, Ukraine
CNCE Precarpathian Clinical Oncologic Center ( Site 0131)
Ivano-Frankivsk, Ukraine
VISION PARTNER Medical Centre ( Site 0134)
Kyiv, Ukraine
Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 0133)
Vinnytsia, Ukraine
Shalimov Institute of Surgery and Transplantation ( Site 0135)
Kyiv, Ukraine
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.