A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this study is to compare how well sonrotoclax plus zanubrutinib works versus zanubrutinib plus placebo in treating adults with relapsed/refractory (R/R) mantle cell lymphoma (MCL). This study will also look at the safety of sonrotoclax plus zanubrutinib versus zanubrutinib plus placebo.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona histologicznie diagnoza chłoniaka płaszcza
- •Możliwość dostarczenia próbki guza do potwierdzenia diagnozy
- •Wcześniejsze leczenie systemowe (1-5 linii) włączając immunoterapię
- •Nawrót choroby lub brak odpowiedzi na ostatnie leczenie
- •Widoczne ogniska guza mierzalne badaniami obrazowymi
- •Dobry ogólny stan zdrowia (skala ECOG 0-2)
- •Prawidłowo funkcjonujące narządy
✗ Disqualifies
- •Wcześniejsze leczenie inhibitorami BCL2
- •Wcześniejsze leczenie degraderami BTK
- •Wcześniejsze leczenie innymi inhibitorami BTK (chyba że pacjent ich nie tolerował)
- •Przeszczep komórek macierzystych w ciągu 3 miesięcy
- •Przeszczep z innego dawcy w ciągu 6 miesięcy
- •Przerzuty chłoniaka do mózgu
- •Poważne choroby serca
- •Udar lub krwawienie do mózgu w ciągu 6 miesięcy
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (155)
University of Alabama At Birmingham Hospital
Birmingham, United States
University of Arizona Cancer Center
Tucson, United States
Ucsf Fresno
Fresno, United States
Kaiser Permanente Southern California
Irvine, United States
Yale University Yale Cancer Center
New Haven, United States
Memorial Cancer Institute, Memorial Healthcare System
Pembroke Pines, United States
Cleveland Clinic Florida
Weston, United States
Rush University Medical Center
Chicago, United States
University of Chicago Medical Center
Chicago, United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne, United States
Mission Cancer and Blood
Waukee, United States
Our Lady of the Lake Hospital
Baton Rouge, United States
The University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, United States
Dana Farber Cancer Institute Longwood Medical Center
Boston, United States
University of Michigan
Ann Arbor, United States
The Cancer and Hematology Centers
Grand Rapids, United States
Mayo Clinic Rochester
Rochester, United States
Hattiesburg Hematology and Oncology Clinic
Hattiesburg, United States
Washington University School of Medicine
St Louis, United States
Nebraska Cancer Specialists St Francis Grand Island
Grand Island, United States
Nebraska Cancer Specialists
Omaha, United States
The Valley Hospital, Inc
Paramus, United States
Memorial Sloan Kettering Cancer Center Mskcc
New York, United States
Atrium Health Levine Cancer Institute (Lci)
Charlotte, United States
Duke University
Durham, United States
Atrium Health Wake Forest Baptist
Winston-Salem, United States
University Hospitals
Cleveland, United States
Cleveland Clinic Foundation
Cleveland, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
Ohio Health Research Institute
Columbus, United States
Penn State Milton S Hershey Medical Center
Hershey, United States
McGlinn Cancer Institute
West Reading, United States
Tennessee Oncology Nashville St Thomas Midtown Clinic
Nashville, United States
Tennessee Oncology
Nashville, United States
Md Anderson Cancer Center
Houston, United States
Texas Oncology Austin Midtown
Round Rock, United States
University of Virginia
Charlottesville, United States
Virgina Cancer Specialists
Gainesville, United States
Vcu Massey Cancer Center
Richmond, United States
Northwest Cancer Specialist, Pc(Us Oncology Research)
Vancouver, United States
University of Wisconsin
Madison, United States
Hospital Aleman
CABA, Argentina
FUNDALEU
Caba, Argentina
Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, Argentina
Hospital Universitario de Cordoba
Córdoba, Argentina
Concord Repatriation General Hospital
Concord, Australia
Genesiscare North Shore
St Leonards, Australia
Westmead Hospital
Westmead, Australia
Sunshine Coast Hospital and Health Service
Birtinya, Australia
Box Hill Hospital
Box Hill, Australia
Monash Health
Clayton, Australia
Rockingham Hospital
Cooloongup, Australia
Linear Clinical Research
Nedlands, Australia
One Clinical Research
Nedlands, Australia
Perth Blood Institute
West Perth, Australia
Ordensklinikum Linz Gmbh Elisabethinen
Linz, Austria
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg
Salzburg, Austria
Uk St Poelten
Sankt Pölten, Austria
Medical University Vienna Oncology
Vienna, Austria
Fundacao Pio Xii Hospital de Amor de Barretos
Barretos, Brazil
Hospital Felicio Rocho
Belo Horizonte, Brazil
Universidade de Campinas Centro de Hematologia E Hemoterapia
Campinas, Brazil
Hospital Erasto Gaertner
Curitiba, Brazil
Instituto Joinvilense de Hematologia E Oncologia
Joinville, Brazil
Fundacao Universidade de Caxias Do Sul Instituto de Pesquisas Em Saude
Petrópolis, Brazil
Hospital de Clinicas de Porto Alegre
Porto AlegreRS, Brazil
Hospital Do Cancer de Pernambuco
Recife, Brazil
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
São Paulo, Brazil
Hospital Santa Rita de Cassia Afecc
Vitória, Brazil
Beijing Cancer Hospital
Beijing, China
Beijing Hospital
Beijing, China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, China
Sun Yat Sen University Cancer Center
Guangzhou, China
Nanfang Hospital, Southern Medical University
Guangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Jiangsu Province Hospital
Nanjing, China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Jiangxi Cancer Hospital
Nanchang, China
Liaoning Cancer Hospital and Institute
Shenyang, China
Shaanxi Provincial Peoples Hospital
Xi'an, China
Linyi Cancer Hospital
Linyi, China
The Affiliated Hospital of Qingdao University Branch West Coast
Qingdao, China
Fudan University Shanghai Cancer Center
Shanghai, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
Chengdu, China
The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan
Hangzhou, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Chu Montpellier Hopital Saint Eloi
Montpellier, France
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, France
Chu Hopital Lyon Sud
PierreBenite, France
Chu Tours Hopital Bretonneau
Tours, France
Klinikum Chemnitz Ggmbh
Chemnitz, Germany
Universitatsklinikum Frankfurt
Frankfurt am Main, Germany
Universitatsklinikum Halle
Halle, Germany
Universitatsklinikum Hamburg Eppendorf
Hamburg, Germany
Stauferklinikum Schwabisch Gmund Kliniken Ostalb
Mutlangen, Germany
Dept of Medicine Iii, University Hospitallmu
München, Germany
Policlinico Sorsola Malpighi, Aou Di Bologna
Bologna, Italy
Ospedale Vito Fazzi, Asl Lecce
Lecce, Italy
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst
Meldola, Italy
Azienda Sanitaria Universitaria Giuliano Isontina
Trieste, Italy
Centroricerche Cliniche Di Verona Srl
Verona, Italy
Aichi Cancer Center Hospital Clinical Oncology
Nagoya, Japan
Toyohashi Municipal Hospital
Toyohashishi, Japan
Chiba Cancer Center
Chiba, Japan
Matsuyama Red Cross Hospital
Matsuyama, Japan
Ogaki Municipal Hospital
Ōgaki, Japan
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
Hiroshima, Japan
Hokkaido University Hospital
Sapporo, Japan
Kobe City Medical Center General Hospital
KobeShi, Japan
Kagoshima University Hospital
Kagoshima, Japan
Kanagawa Cancer Center
Yokohama, Japan
Tohoku University Hospital
Sendai, Japan
Kurashiki Central Hospital
Kurashikishi, Japan
National Hospital Organization Okayama Medical Center
Okayama, Japan
Osaka Metropolitan University Hospital
Osaka, Japan
Osaka Red Cross Hospital
Osakashi, Japan
Dokkyo Medical University Saitama Medical Center
Koshigaya, Japan
Institute of Science Tokyo Hospital
Bunkyoku, Japan
Yokohama Municipal Citizens Hospital
Yokohama, Japan
North Shore Hospital
Auckland, New Zealand
Christchurch Hospital
Christchurch, New Zealand
Dunedin Hospital
Dunedin, New Zealand
Tauranga Hospital
Tauranga, New Zealand
Wellington Regional Hospital (Ccdhb)
Wellington, New Zealand
Pratia McM Krakow
Krakow, Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
Lodz, Poland
Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie
Lublin, Poland
Aidport Sp Z O O
Skorzewo, Poland
Dolnoslaskie Centrum Onkologii, Pulmonologii I Hematologii
Wroclaw, Poland
Auxilio Mutuo Cancer Center
San Juan, Puerto Rico
Pusan National University Hospital
Seogu, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Samsung Medical Center
GangnamGu, South Korea
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, South Korea
Seoul National University Hospital
Seoul, South Korea
Asan Medical Center
SongpaGu, South Korea
The Catholic University of Korea, Yeouido St Marys Hospital
Yeongdeungpo-gu, South Korea
Hospital Clinic de Barcelona
Barcelona, Spain
Ico H Duran I Reynals
Barcelona, Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain
H Puerta de Hierro Majadahonda
Majadahonda, Spain
Etlik City Hospital
Ankara, Turkey (Türkiye)
Antalya Memorial Hospital
Dokuma, Turkey (Türkiye)
Kocaeli Universitesi Tip Fakultesi
Kocaeli, Turkey (Türkiye)
Birmingham Heartlands Hospital
Birmingham, United Kingdom
The Royal Bournemouth and Christchurch Hospitals Nhs Foundation
Bournemouth, United Kingdom
Beatson West of Scotland Cancer Centre
Glasgow, United Kingdom
Oxford University Hospitals Nhs Trust Churchill Hospital
Headington, United Kingdom
University College Hospital
London, United Kingdom
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, United Kingdom
Derriford Hospital
Plymouth, United Kingdom
Trial contact
Study Director
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.
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