RecruitingPhase III🇵🇱 PolandEN original

A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The goal of this study is to compare how well sonrotoclax plus zanubrutinib works versus zanubrutinib plus placebo in treating adults with relapsed/refractory (R/R) mantle cell lymphoma (MCL). This study will also look at the safety of sonrotoclax plus zanubrutinib versus zanubrutinib plus placebo.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzona histologicznie diagnoza chłoniaka płaszcza
  • Możliwość dostarczenia próbki guza do potwierdzenia diagnozy
  • Wcześniejsze leczenie systemowe (1-5 linii) włączając immunoterapię
  • Nawrót choroby lub brak odpowiedzi na ostatnie leczenie
  • Widoczne ogniska guza mierzalne badaniami obrazowymi
  • Dobry ogólny stan zdrowia (skala ECOG 0-2)
  • Prawidłowo funkcjonujące narządy

✗ Disqualifies

  • Wcześniejsze leczenie inhibitorami BCL2
  • Wcześniejsze leczenie degraderami BTK
  • Wcześniejsze leczenie innymi inhibitorami BTK (chyba że pacjent ich nie tolerował)
  • Przeszczep komórek macierzystych w ciągu 3 miesięcy
  • Przeszczep z innego dawcy w ciągu 6 miesięcy
  • Przerzuty chłoniaka do mózgu
  • Poważne choroby serca
  • Udar lub krwawienie do mózgu w ciągu 6 miesięcy

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 22, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (155)

University of Alabama At Birmingham Hospital

Birmingham, United States

University of Arizona Cancer Center

Tucson, United States

Ucsf Fresno

Fresno, United States

Kaiser Permanente Southern California

Irvine, United States

Yale University Yale Cancer Center

New Haven, United States

Memorial Cancer Institute, Memorial Healthcare System

Pembroke Pines, United States

Cleveland Clinic Florida

Weston, United States

Rush University Medical Center

Chicago, United States

University of Chicago Medical Center

Chicago, United States

Fort Wayne Medical Oncology and Hematology

Fort Wayne, United States

Mission Cancer and Blood

Waukee, United States

Our Lady of the Lake Hospital

Baton Rouge, United States

The University of Maryland Greenebaum Comprehensive Cancer Center

Baltimore, United States

Dana Farber Cancer Institute Longwood Medical Center

Boston, United States

University of Michigan

Ann Arbor, United States

The Cancer and Hematology Centers

Grand Rapids, United States

Mayo Clinic Rochester

Rochester, United States

Hattiesburg Hematology and Oncology Clinic

Hattiesburg, United States

Washington University School of Medicine

St Louis, United States

Nebraska Cancer Specialists St Francis Grand Island

Grand Island, United States

Nebraska Cancer Specialists

Omaha, United States

The Valley Hospital, Inc

Paramus, United States

Memorial Sloan Kettering Cancer Center Mskcc

New York, United States

Atrium Health Levine Cancer Institute (Lci)

Charlotte, United States

Duke University

Durham, United States

Atrium Health Wake Forest Baptist

Winston-Salem, United States

University Hospitals

Cleveland, United States

Cleveland Clinic Foundation

Cleveland, United States

Ohio State University Comprehensive Cancer Center

Columbus, United States

Ohio Health Research Institute

Columbus, United States

Penn State Milton S Hershey Medical Center

Hershey, United States

McGlinn Cancer Institute

West Reading, United States

Tennessee Oncology Nashville St Thomas Midtown Clinic

Nashville, United States

Tennessee Oncology

Nashville, United States

Md Anderson Cancer Center

Houston, United States

Texas Oncology Austin Midtown

Round Rock, United States

University of Virginia

Charlottesville, United States

Virgina Cancer Specialists

Gainesville, United States

Vcu Massey Cancer Center

Richmond, United States

Northwest Cancer Specialist, Pc(Us Oncology Research)

Vancouver, United States

University of Wisconsin

Madison, United States

Hospital Aleman

CABA, Argentina

FUNDALEU

Caba, Argentina

Hospital Italiano de Buenos Aires

Ciudad Autonoma Buenos Aires, Argentina

Hospital Universitario de Cordoba

Córdoba, Argentina

Concord Repatriation General Hospital

Concord, Australia

Genesiscare North Shore

St Leonards, Australia

Westmead Hospital

Westmead, Australia

Sunshine Coast Hospital and Health Service

Birtinya, Australia

Box Hill Hospital

Box Hill, Australia

Monash Health

Clayton, Australia

Rockingham Hospital

Cooloongup, Australia

Linear Clinical Research

Nedlands, Australia

One Clinical Research

Nedlands, Australia

Perth Blood Institute

West Perth, Australia

Ordensklinikum Linz Gmbh Elisabethinen

Linz, Austria

Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg

Salzburg, Austria

Uk St Poelten

Sankt Pölten, Austria

Medical University Vienna Oncology

Vienna, Austria

Fundacao Pio Xii Hospital de Amor de Barretos

Barretos, Brazil

Hospital Felicio Rocho

Belo Horizonte, Brazil

Universidade de Campinas Centro de Hematologia E Hemoterapia

Campinas, Brazil

Hospital Erasto Gaertner

Curitiba, Brazil

Instituto Joinvilense de Hematologia E Oncologia

Joinville, Brazil

Fundacao Universidade de Caxias Do Sul Instituto de Pesquisas Em Saude

Petrópolis, Brazil

Hospital de Clinicas de Porto Alegre

Porto AlegreRS, Brazil

Hospital Do Cancer de Pernambuco

Recife, Brazil

Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular

São Paulo, Brazil

Hospital Santa Rita de Cassia Afecc

Vitória, Brazil

Beijing Cancer Hospital

Beijing, China

Beijing Hospital

Beijing, China

The First Affiliated Hospital of Chongqing Medical University

Chongqing, China

Sun Yat Sen University Cancer Center

Guangzhou, China

Nanfang Hospital, Southern Medical University

Guangzhou, China

Harbin Medical University Cancer Hospital

Harbin, China

The First Affiliated Hospital of Zhengzhou University

Zhengzhou, China

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Wuhan, China

Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology

Wuhan, China

Jiangsu Province Hospital

Nanjing, China

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, China

Jiangxi Cancer Hospital

Nanchang, China

Liaoning Cancer Hospital and Institute

Shenyang, China

Shaanxi Provincial Peoples Hospital

Xi'an, China

Linyi Cancer Hospital

Linyi, China

The Affiliated Hospital of Qingdao University Branch West Coast

Qingdao, China

Fudan University Shanghai Cancer Center

Shanghai, China

Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

Chengdu, China

The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan

Hangzhou, China

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, China

Chu Montpellier Hopital Saint Eloi

Montpellier, France

Centre Hospitalier Universitaire Nantes Hotel Dieu

Nantes, France

Chu Hopital Lyon Sud

PierreBenite, France

Chu Tours Hopital Bretonneau

Tours, France

Klinikum Chemnitz Ggmbh

Chemnitz, Germany

Universitatsklinikum Frankfurt

Frankfurt am Main, Germany

Universitatsklinikum Halle

Halle, Germany

Universitatsklinikum Hamburg Eppendorf

Hamburg, Germany

Stauferklinikum Schwabisch Gmund Kliniken Ostalb

Mutlangen, Germany

Dept of Medicine Iii, University Hospitallmu

München, Germany

Policlinico Sorsola Malpighi, Aou Di Bologna

Bologna, Italy

Ospedale Vito Fazzi, Asl Lecce

Lecce, Italy

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori Irst

Meldola, Italy

Azienda Sanitaria Universitaria Giuliano Isontina

Trieste, Italy

Centroricerche Cliniche Di Verona Srl

Verona, Italy

Aichi Cancer Center Hospital Clinical Oncology

Nagoya, Japan

Toyohashi Municipal Hospital

Toyohashishi, Japan

Chiba Cancer Center

Chiba, Japan

Matsuyama Red Cross Hospital

Matsuyama, Japan

Ogaki Municipal Hospital

Ōgaki, Japan

Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital

Hiroshima, Japan

Hokkaido University Hospital

Sapporo, Japan

Kobe City Medical Center General Hospital

KobeShi, Japan

Kagoshima University Hospital

Kagoshima, Japan

Kanagawa Cancer Center

Yokohama, Japan

Tohoku University Hospital

Sendai, Japan

Kurashiki Central Hospital

Kurashikishi, Japan

National Hospital Organization Okayama Medical Center

Okayama, Japan

Osaka Metropolitan University Hospital

Osaka, Japan

Osaka Red Cross Hospital

Osakashi, Japan

Dokkyo Medical University Saitama Medical Center

Koshigaya, Japan

Institute of Science Tokyo Hospital

Bunkyoku, Japan

Yokohama Municipal Citizens Hospital

Yokohama, Japan

North Shore Hospital

Auckland, New Zealand

Christchurch Hospital

Christchurch, New Zealand

Dunedin Hospital

Dunedin, New Zealand

Tauranga Hospital

Tauranga, New Zealand

Wellington Regional Hospital (Ccdhb)

Wellington, New Zealand

Pratia McM Krakow

Krakow, Poland

Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi

Lodz, Poland

Uniwersytecki Szpital Kliniczny Nr 4 W Lublinie

Lublin, Poland

Aidport Sp Z O O

Skorzewo, Poland

Dolnoslaskie Centrum Onkologii, Pulmonologii I Hematologii

Wroclaw, Poland

Auxilio Mutuo Cancer Center

San Juan, Puerto Rico

Pusan National University Hospital

Seogu, South Korea

Seoul National University Bundang Hospital

Seongnam-si, South Korea

Samsung Medical Center

GangnamGu, South Korea

The Catholic University of Korea, Seoul St Marys Hospital

SeochoGu, South Korea

Severance Hospital Yonsei University Health System

SeodaemunGu, South Korea

Seoul National University Hospital

Seoul, South Korea

Asan Medical Center

SongpaGu, South Korea

The Catholic University of Korea, Yeouido St Marys Hospital

Yeongdeungpo-gu, South Korea

Hospital Clinic de Barcelona

Barcelona, Spain

Ico H Duran I Reynals

Barcelona, Spain

Hospital Universitario Fundacion Jimenez Diaz

Madrid, Spain

H Puerta de Hierro Majadahonda

Majadahonda, Spain

Etlik City Hospital

Ankara, Turkey (Türkiye)

Antalya Memorial Hospital

Dokuma, Turkey (Türkiye)

Kocaeli Universitesi Tip Fakultesi

Kocaeli, Turkey (Türkiye)

Birmingham Heartlands Hospital

Birmingham, United Kingdom

The Royal Bournemouth and Christchurch Hospitals Nhs Foundation

Bournemouth, United Kingdom

Beatson West of Scotland Cancer Centre

Glasgow, United Kingdom

Oxford University Hospitals Nhs Trust Churchill Hospital

Headington, United Kingdom

University College Hospital

London, United Kingdom

Clatterbridge Cancer Centre

Metropolitan Borough of Wirral, United Kingdom

Derriford Hospital

Plymouth, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.

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