RecruitingPhase IIIEN originalMelanomaMetastatic / advanced

SUPRAME-ACTengine® IMA203 vs. Investigator's Choice of Treatment in Previously Treated, Unresectable or Metastatic Cutaneous Melanoma

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This clinical trial is a prospective, multicenter, open-label, randomized, actively controlled, parallel-group Phase 3 clinical trial to evaluate the efficacy, safety and tolerability of treatment with IMA203 administered at the recommended phase 2 dose versus investigator's choice of treatment in patients with previously treated, unresectable or metastatic cutaneous melanoma. For patients interested in additional information on how to participate, please follow this link: https://mytomorrows.com/trials/suprame/en-us/

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony czerniak skóry, który się rozszerzył na inne części ciała lub nie da się go operować
  • Posiadanie specjalnego markera genetycznego (HLA-A*02:01)
  • Wcześniejsze leczenie lekami hamującymi PD-1 bez efektu lub z powodu skutków ubocznych
  • Oczekiwana długość życia ponad 6 miesięcy
  • Możliwość zmierzenia guza za pomocą badań obrazowych
  • Dobry ogólny stan zdrowotny (możliwość samodzielnej opieki nad sobą)
  • Gotowość do stosowania antykoncepcji przez okres leczenia i pół roku po nim

✗ Disqualifies

  • Czerniak błon śluzowych (jamy ustnej, nosa) lub oka
  • Inne nowotwory w ciągu ostatnich 3 lat (poza rakiem skóry basalioma)
  • Poważne choroby autoimmunologiczne

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
August 18, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (71)

Mayo Clinic

Phoenix, United States

Honor Health Research Institute

Scottsdale, United States

City of Hope National Medical Center

Duarte, United States

UC San Diego Moores Cancer Center

La Jolla, United States

UCLA Hematology/Oncology

Los Angeles, United States

UCSF Helen Diller Family Comprehensive Cancer Center

San Francisco, United States

Stanford Cancer Center

Stanford, United States

University of Colorado, Anschutz Medical Campus

Aurora, United States

Yale Cancer Center

New Haven, United States

Mayo Clinic Florida

Jacksonville, United States

University of Miami - Sylvester Comprehensive Cancer Cente

Miami, United States

AdventHealth, Orlando

Orlando, United States

Moffitt Cancer Center

Tampa, United States

Winship Cancer Institute, Emory University

Atlanta, United States

University of Chicago Medical Center

Chicago, United States

University of MD Greenebaum Comprehensive Cancer Center

Baltimore, United States

Massachusetts General Hospital

Boston, United States

Beth Israel Deaconess Medical Center

Boston, United States

University of Michigan

Ann Arbor, United States

Mayo Clinic

Rochester, United States

University of Nebraska Medical Center

Omaha, United States

Atlantic Health System/Morristown Medical Center

Morristown, United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health

New York, United States

Memorial Sloan Kettering Cancer Center

New York, United States

University of Rochester

Rochester, United States

UNC Hospitals, The University of North Carolina at Chapel Hill

Chapel Hill, United States

Cleveland Clinic, Taussig Cancer Institute

Cleveland, United States

Ohio State University

Columbus, United States

Providence Cancer Institute Franz Clinic

Portland, United States

Lehigh Valley Topper Cancer Institute

Allentown, United States

University of Pennsylvania, Abramson Cancer Center

Philadelphia, United States

Thomas Jeffersion University, Sidney Kimmel Cancer Center

Philadelphia, United States

Fox Chase Cancer Center

Philadelphia, United States

UPMC Hillman Cancer Center

Pittsburgh, United States

Avera Cancer Institute

Sioux Falls, United States

SCRI Oncology Partners

Nashville, United States

Baylor University

Dallas, United States

University of Texas Southwestern Medical Center

Dallas, United States

The University of Texas MD Anderson Cancer Center

Houston, United States

Huntsman Cancer Institute, University of Utah

Salt Lake City, United States

Virginia Commonwealth University

Richmond, United States

Fred Hutchinson Cancer Center

Seattle, United States

University of Wisconsin

Madison, United States

Cross Cancer Institute, Alberta

Edmonton, Canada

BC Cancer - Vancouver

Vancouver, Canada

University Health Network, Princess Margaret Cancer Centre

Toronto, Canada

Centre hospitalier de l'Université de Montréal (CHUM)

Montreal, Canada

Centre Hospitalier Universitaire De Lille

Lille, France

Assistance Publique Hopitaux De Paris, Hôpital Saint Louis

Paris, France

Institut Gustave Roussy

Villejuif, France

Universitatsklinikum Koeln

Cologne, Germany

Charite Universitaetsmedizin Berlin KöR

Berlin, Germany

Universitaetsklinikum Bonn AöR

Bonn, Germany

Technische Universitaet Dresden

Dresden, Germany

Universitaetsklinikum Erlangen AöR

Erlangen, Germany

Universitaetsklinikum Essen AöR

Essen, Germany

Goethe University Frankfurt

Frankfurt am Main, Germany

University Medical Center Hamburg-Eppendorf

Hamburg, Germany

Universitaetsklinikum Heidelberg AöR

Heidelberg, Germany

Universitaet Leipzig

Leipzig, Germany

Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR

Mainz, Germany

Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting

Amsterdam, Netherlands

Universitair Medisch Centrum Groningen

Groningen, Netherlands

Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC)

Rotterdam, Netherlands

Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital

Cambridge, United Kingdom

Greater Glasgow and Clyde NHS, Beatson West of Scotland Cancer Center

Glasgow, United Kingdom

Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital

London, United Kingdom

The Royal Marsden NHS Foundation Trust

London, United Kingdom

The Christie NHS Foundation Trust

Manchester, United Kingdom

Oxford University Hospitals NHS Foundation Trust, Churchill Hospital

Oxford, United Kingdom

University of Southampton NHS Foundation Trust, Southampton General Hospital

Southampton, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/19/2026.

You can help another person

We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.