A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase Ⅲ, randomized, open-label, Sponsor-blinded, 3-arm, global, multicenter study assessing the efficacy and safety of rilvegostomig in combination with fluoropyrimidine and T-DXd (Arm A) compared to trastuzumab, chemotherapy, and pembrolizumab (Arm B) in HER2-positive locally advanced or metastatic gastric or GEJ adenocarcinoma participants whose tumors express PD L1 CPS ≥ 1. Rilvegostomig in combination with trastuzumab and chemotherapy will be evaluated in a separate arm (Arm C) to assess the contribution of each component in the experimental arm.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony rak żołądka typu HER2-dodatni
- •Guz nigdy wcześniej nie leczony, który nie da się usunąć operacyjnie lub rozprzestrzenił się na inne części ciała
- •Ogólny stan zdrowia pozwalający na leczenie (ocena funkcjonalna 0-1)
- •Dostępna próbka tkanki guza do badań laboratoryjnych
- •Prawidłowo funkcjonujące narządy i szpik kostny
- •Serce pompuje prawidłowo (frakcja wyrzutu lewej komory ≥50%)
- •Brak poprzedniego leczenia przeciwnowotworowego lub wystarczająco długa przerwa od ostatniego leczenia
✗ Disqualifies
- •Uszkodzenie górnego przewodu pokarmowego uniemożliwiające przyjmowanie leków
- •Niedobór enzymu warunkującego metabolizm pewnych leków przeciwnowotworowych
- •Wcześniejsze niepowodzenia lub alergię na stosowane leki (pembrolizumab, trastuzumab lub chemioterapię)
- •Przerzuty do mózgu lub rdzenia kręgowego, jeśli powodują objawy
- •Aktywne lub niekontrolowane zakażenie, w tym gruźlicę lub zapalenie wątroby
- •Niedawne podanie żywej szczepionki
- •Aktywne zapalenie autoimmunologiczne wymagające stałego leczenia sterydami
- •Poważne problemy z sercem lub zaburzenia psychiczne
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (304)
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Anchorage, United States
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Phoenix, United States
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Duarte, United States
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La Jolla, United States
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Los Alamitos, United States
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Los Angeles, United States
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Los Angeles, United States
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Santa Monica, United States
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Solvang, United States
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Upland, United States
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Walnut Creek, United States
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Aurora, United States
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Newark, United States
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Jacksonville, United States
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Jacksonville, United States
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Orlando, United States
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Athens, United States
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Marietta, United States
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Chicago, United States
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Chicago, United States
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Evanston, United States
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Hinsdale, United States
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Niles, United States
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Dyer, United States
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Waukee, United States
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Lexington, United States
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Louisville, United States
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Silver Spring, United States
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Boston, United States
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Boston, United States
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Worcester, United States
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Detroit, United States
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Grand Rapids, United States
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Burnsville, United States
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Kansas City, United States
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St Louis, United States
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Omaha, United States
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Reno, United States
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Summit, United States
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Santa Fe, United States
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Albany, United States
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Clifton Park, United States
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New Hyde Park, United States
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New York, United States
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Cincinnati, United States
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Columbus, United States
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Oklahoma City, United States
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Lancaster, United States
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Knoxville, United States
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Nashville, United States
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Dallas, United States
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Round Rock, United States
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Webster, United States
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Charlottesville, United States
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Fairfax, United States
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Fairfax, United States
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Richmond, United States
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Charleston, United States
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Madison, United States
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Buenos Aires, Argentina
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Ciudad Autónoma Buenos Aires, Argentina
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Ciudad de Buenos Aires, Argentina
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Rosario, Argentina
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Rosario, Argentina
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Viedma, Argentina
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Darlinghurst, Australia
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Heidelberg, Australia
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Murdoch, Australia
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Westmead, Australia
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Linz, Austria
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Salzburg, Austria
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Vienna, Austria
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Wiener Neustadt, Austria
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Edegem, Belgium
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Ghent, Belgium
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Leuven, Belgium
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Liège, Belgium
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Barretos, Brazil
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Brasília, Brazil
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Campo Grande, Brazil
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Natal, Brazil
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Porto Alegre, Brazil
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Recife, Brazil
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Salvador, Brazil
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São Paulo, Brazil
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Vitória, Brazil
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Calgary, Canada
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Edmonton, Canada
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Winnipeg, Canada
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Barrie, Canada
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Brampton, Canada
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Hamilton, Canada
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Toronto, Canada
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Chicoutimi, Canada
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Lévis, Canada
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Montreal, Canada
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Port Montt, Chile
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Rancagua, Chile
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Santiago, Chile
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Santiago, Chile
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Santiago, Chile
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Temuco, Chile
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Viña del Mar, Chile
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Anyang, China
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Beijing, China
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Beijing, China
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Bengbu, China
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Changchun, China
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Changsha, China
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Chengdu, China
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Fuzhou, China
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Fuzhou, China
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Guangzhou, China
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Guangzhou, China
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Guangzhou, China
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Hangzhou, China
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Harbin, China
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Hefei, China
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Hefei, China
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Jinan, China
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Kunming, China
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Lanzhou, China
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Linfen, China
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Linyi, China
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Nanchang, China
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Nanjing, China
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Nanjing, China
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Shandong, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shenyang, China
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Shenyang, China
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Shijiazhuang, China
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Tianjin, China
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Wenzhou, China
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Wuhan, China
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Xi'an, China
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Xi'an, China
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Xining, China
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Yinchuan, China
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Zhengzhou, China
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Bordeaux, France
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Caen, France
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Clermont-Ferrand, France
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Dijon, France
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Lyon, France
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Marseille, France
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Poitiers, France
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Rennes, France
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Toulouse, France
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Vandœuvre-lès-Nancy, France
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Villejuif, France
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Augsburg, Germany
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Bad Saarow, Germany
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Berlin, Germany
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Berlin, Germany
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Berlin, Germany
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Braunschweig, Germany
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Chemnitz, Germany
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Düsseldorf, Germany
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Erlangen, Germany
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Essen, Germany
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Frankfurt, Germany
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Göttingen, Germany
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Hamburg, Germany
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Leipzig, Germany
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Ludwigshafen, Germany
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Lübeck, Germany
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Mainz, Germany
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Mannheim, Germany
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Regensburg, Germany
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Tübingen, Germany
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Ulm, Germany
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Hong Kong, Hong Kong
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Hong Kong, Hong Kong
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Hong Kong, Hong Kong
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Budapest, Hungary
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Budapest, Hungary
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Budapest, Hungary
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Gyöngyös, Hungary
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Győr, Hungary
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Gyula, Hungary
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Zalaegerszeg, Hungary
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Ansārinagar, India
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Bangalore, India
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Delhi, India
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Delhi, India
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Hyderabad, India
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Kolkata, India
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Mumbai, India
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Varanasi, India
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Cagliari, Italy
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Florence, Italy
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Milan, Italy
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Naples, Italy
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Padova, Italy
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Rozzano, Italy
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Torino, Italy
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Tricase, Italy
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Akashi-shi, Japan
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Bunkyō City, Japan
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Chūōku, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Hidaka-shi, Japan
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Hirakata-shi, Japan
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Hiroshima, Japan
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Kasama-shi, Japan
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Kita-gun, Japan
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Kitaadachi-gun, Japan
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Kōtoku, Japan
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Matsuyama, Japan
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Niigata, Japan
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Osaka, Japan
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Osakasayama-shi, Japan
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Ota-shi, Japan
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Sakaishi, Japan
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Sendai, Japan
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Shiwa-gun, Japan
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Suita-shi, Japan
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Sunto-gun, Japan
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Toyoake-shi, Japan
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Yokohama, Japan
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Yokohama, Japan
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George Town, Malaysia
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Ipoh, Malaysia
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Kuala Lumpur, Malaysia
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Kuala Lumpur, Malaysia
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Sabak Bernam, Malaysia
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Amsterdam, Netherlands
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Arnhem, Netherlands
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Leiden, Netherlands
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Arequipa, Peru
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Callao, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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Lima, Peru
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San Isidro, Peru
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Bialystok, Poland
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Gdansk, Poland
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Koszalin, Poland
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Lodz, Poland
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Olsztyn, Poland
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Przemyśl, Poland
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Tomaszów Mazowiecki, Poland
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Warsaw, Poland
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Wroclaw, Poland
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Rio Piedras, Puerto Rico
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Daegu, South Korea
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Goyang-si, South Korea
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Gyeonggi-do, South Korea
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Jeonnam, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Seoul, South Korea
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Badalona, Spain
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Barcelona, Spain
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Madrid, Spain
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Madrid, Spain
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Ourense, Spain
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Santander, Spain
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Seville, Spain
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Valencia, Spain
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Kaohsiung City, Taiwan
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Kaohsiung City, Taiwan
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Taichung, Taiwan
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Taichung, Taiwan
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Tainan, Taiwan
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Tainan, Taiwan
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Taipei, Taiwan
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Taipei, Taiwan
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Taoyuan, Taiwan
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Bangkok, Thailand
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Bangkok, Thailand
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Bangkok, Thailand
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Banphaeo, Thailand
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Dusit, Thailand
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Khon Kaen, Thailand
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Muang, Thailand
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Ankara, Turkey (Türkiye)
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Antalya, Turkey (Türkiye)
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Diyarbakır, Turkey (Türkiye)
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Erzurum, Turkey (Türkiye)
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Istanbul, Turkey (Türkiye)
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Izmir, Turkey (Türkiye)
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Mezitli, Turkey (Türkiye)
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Cambridge, United Kingdom
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Coventry, United Kingdom
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Dundee, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Manchester, United Kingdom
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Sutton, United Kingdom
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Hanoi, Vietnam
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Ho Chi Minh City, Vietnam
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Ho Chi Minh City, Vietnam
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Hồ Chí Minh, Vietnam
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Viet Tri, Vietnam
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Vinh, Vietnam
Trial contact
AstraZeneca Clinical Study Information Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/12/2026.
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