Testing the Addition of the Immunotherapy Drug, Pembrolizumab, to Radiation Therapy Compared to the Usual Chemotherapy Treatment During Radiation Therapy for Bladder Cancer, PARRC Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial compares the use of pembrolizumab and radiation therapy to chemotherapy with cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C and radiation therapy for the treatment of non-muscle invasive bladder cancer. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as cisplatin, gemcitabine, 5-fluorouracil or mitomycin-C, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Giving pembrolizumab with radiation may kill more tumor cells than chemotherapy with radiation therapy in patients with non-muscle invasive bladder cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Rak pęcherza moczowego, który nie nacieka głęboko mięśni, nie rozprzestrzenił się na węzły chłonne ani inne części ciała, i który zazwyczaj leczony jest operacyjnie.
- •Choroba potwierdzona badaniem histologicznym (rodzaj raka to 'urotelialny rak' o wysokim stopniu złośliwości).
- •Jeśli rak powrócił po leczeniu, musiał spełnić jeden z poniższych warunków: nawrót z rakiem wysokiego stopnia po wcześniejszym leczeniu; rak wysokiego stopnia z cechami zwiększonego ryzyka; rak wysokiego stopnia, który nie ustąpił po pierwszym zabiegu (TURBT).
- •Przed rozpoczęciem badania wykonano ponowne badanie usuniętej tkanki (TURBT), które potwierdziło brak głębokiego nacieku mięśni i usunięcie widocznych zmian.
- •Pacjenci powinni mieć zalecane usunięcie pęcherza moczowego (cystektomię), ale nie muszą być operacyjnie zdolni do tej operacji, aby wziąć udział w badaniu.
✗ Disqualifies
- •Obecność zmian w węzłach chłonnych większych niż 1 cm lub podejrzanych zmian w badaniu PET.
- •Rak pęcherza wyłącznie płaskonabłonkowy.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (134)
Highlands Oncology Group - Fayetteville
Fayetteville, United States
Highlands Oncology Group - Rogers
Rogers, United States
Highlands Oncology Group
Springdale, United States
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, United States
Los Angeles General Medical Center
Los Angeles, United States
USC / Norris Comprehensive Cancer Center
Los Angeles, United States
Shaw Cancer Center
Edwards, United States
Helen F Graham Cancer Center
Newark, United States
Medical Oncology Hematology Consultants PA
Newark, United States
UF Health Cancer Institute - Gainesville
Gainesville, United States
Mount Sinai Medical Center
Miami Beach, United States
Grady Health System
Atlanta, United States
Emory Proton Therapy Center
Atlanta, United States
Emory University Hospital Midtown
Atlanta, United States
Emory University Hospital/Winship Cancer Institute
Atlanta, United States
Emory Saint Joseph's Hospital
Atlanta, United States
Rush MD Anderson Cancer Center
Chicago, United States
Carle at The Riverfront
Danville, United States
Cancer Care Specialists of Illinois - Decatur
Decatur, United States
Decatur Memorial Hospital
Decatur, United States
Carle Physician Group-Effingham
Effingham, United States
Crossroads Cancer Center
Effingham, United States
Carle Physician Group-Mattoon/Charleston
Mattoon, United States
Carle BroMenn Medical Center
Normal, United States
Carle Cancer Institute Normal
Normal, United States
HSHS Saint Elizabeth's Hospital
O'Fallon, United States
Southern Illinois University School of Medicine
Springfield, United States
Springfield Clinic
Springfield, United States
Springfield Memorial Hospital
Springfield, United States
Carle Cancer Center
Urbana, United States
Mary Greeley Medical Center
Ames, United States
McFarland Clinic - Ames
Ames, United States
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, United States
Mercy Cancer Center-West Lakes
Clive, United States
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, United States
Iowa Methodist Medical Center
Des Moines, United States
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, United States
Broadlawns Medical Center
Des Moines, United States
Mercy Medical Center - Des Moines
Des Moines, United States
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, United States
UI Healthcare Mission Cancer and Blood - Pella
Pella, United States
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, United States
The Iowa Clinic PC
West Des Moines, United States
University of Kansas Cancer Center
Kansas City, United States
University of Kansas Cancer Center-Overland Park
Overland Park, United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, United States
Louisiana Hematology Oncology Associates LLC
Baton Rouge, United States
Mary Bird Perkins Cancer Center
Baton Rouge, United States
Mary Bird Perkins Cancer Center - Gonzales
Gonzales, United States
Mary Bird Perkins Cancer Center - Metairie
Metairie, United States
Massachusetts General Hospital Cancer Center
Boston, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, United States
Trinity Health Medical Center - Brighton
Brighton, United States
Trinity Health Medical Center - Canton
Canton, United States
Chelsea Hospital
Chelsea, United States
University of Michigan Health - Sparrow Lansing
Lansing, United States
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, United States
Michigan Healthcare Professionals Pontiac
Pontiac, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, United States
Sanford Joe Lueken Cancer Center
Bemidji, United States
Essentia Health Saint Joseph's Medical Center
Brainerd, United States
Essentia Health - Deer River Clinic
Deer River, United States
Essentia Health Cancer Center
Duluth, United States
Essentia Health Saint Mary's Medical Center
Duluth, United States
Miller-Dwan Hospital
Duluth, United States
Essentia Health Hibbing Clinic
Hibbing, United States
Essentia Health Sandstone
Sandstone, United States
Essentia Health Virginia Clinic
Virginia, United States
Saint Francis Medical Center
Cape Girardeau, United States
Parkland Health Center - Farmington
Farmington, United States
University of Kansas Cancer Center - Briarcliff
Kansas City, United States
University of Kansas Cancer Center - North
Kansas City, United States
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, United States
Lake Regional Hospital
Osage Beach, United States
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, United States
Mercy Hospital South
St Louis, United States
Missouri Baptist Medical Center
St Louis, United States
Mercy Hospital Saint Louis
St Louis, United States
Missouri Baptist Sullivan Hospital
Sullivan, United States
BJC Outpatient Center at Sunset Hills
Sunset Hills, United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, United States
Memorial Sloan Kettering Monmouth
Middletown, United States
Memorial Sloan Kettering Bergen
Montvale, United States
Memorial Sloan Kettering Commack
Commack, United States
Memorial Sloan Kettering Westchester
Harrison, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Memorial Sloan Kettering Nassau
Uniondale, United States
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, United States
Sanford Broadway Medical Center
Fargo, United States
Sanford Roger Maris Cancer Center
Fargo, United States
Riverside Methodist Hospital
Columbus, United States
Grant Medical Center
Columbus, United States
Doctors Hospital
Columbus, United States
Dublin Methodist Hospital
Dublin, United States
OhioHealth Mansfield Hospital
Mansfield, United States
OhioHealth Marion General Hospital
Marion, United States
University of Oklahoma Health Sciences Center
Oklahoma City, United States
Christiana Care Health System-Concord Health Center
Chadds Ford, United States
Geisinger Medical Center
Danville, United States
Geisinger Cancer Center Dickson City
Dickson City, United States
UPMC Hillman Cancer Center Erie
Erie, United States
UPMC Cancer Center at UPMC Horizon
Farrell, United States
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, United States
Penn State Milton S Hershey Medical Center
Hershey, United States
Geisinger Medical Oncology-Lewisburg
Lewisburg, United States
UPMC Cancer Center - Monroeville
Monroeville, United States
UPMC Hillman Cancer Center - Monroeville
Monroeville, United States
UPMC Hillman Cancer Center - New Castle
New Castle, United States
UPMC-Magee Womens Hospital
Pittsburgh, United States
UPMC-Saint Margaret
Pittsburgh, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
UPMC-Shadyside Hospital
Pittsburgh, United States
UPMC-Passavant Hospital
Pittsburgh, United States
UPMC Cancer Center at UPMC Northwest
Seneca, United States
UPMC Cancer Center-Washington
Washington, United States
UPMC Washington Hospital Radiation Oncology
Washington, United States
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, United States
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, United States
University of Vermont Medical Center
Burlington, United States
University of Vermont and State Agricultural College
Burlington, United States
University of Virginia Cancer Center
Charlottesville, United States
Bon Secours Memorial Regional Medical Center
Mechanicsville, United States
Bon Secours Saint Francis Medical Center
Midlothian, United States
Bon Secours Saint Mary's Hospital
Richmond, United States
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, United States
VCU Massey Comprehensive Cancer Center
Richmond, United States
VCU Community Memorial Health Center
South Hill, United States
West Virginia University Healthcare
Morgantown, United States
Duluth Clinic Ashland
Ashland, United States
Northwest Wisconsin Cancer Center
Ashland, United States
Marshfield Medical Center - Weston
Weston, United States
The Research Institute of the McGill University Health Centre (MUHC)
Montreal, Canada
CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
Québec, Canada
Trial contact
Site Public Contact
Joseph T. Beck
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Luis Mariscal
PRINCIPAL_INVESTIGATOR
Site Public Contact
Lauren A. Lukas
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Erin Schwab
PRINCIPAL_INVESTIGATOR
Site Public Contact
Gregory A. Masters
PRINCIPAL_INVESTIGATOR
Site Public Contact
Daniel V. Araujo
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bruno R. Bastos
PRINCIPAL_INVESTIGATOR
Site Public Contact
Kamran Salari
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Dian Wang
PRINCIPAL_INVESTIGATOR
Site Public Contact
Daniel H. Barnett
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bryan A. Faller
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Joseph J. Merchant
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Seema Harichand-Herdt
PRINCIPAL_INVESTIGATOR
Richard L. Deming
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Eugene K. Lee
PRINCIPAL_INVESTIGATOR
Site Public Contact
Scott E. Delacroix
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Sophia C. Kamran
PRINCIPAL_INVESTIGATOR
Site Public Contact
Samir Narayan
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Bret E. Friday
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Jay W. Carlson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Justin M. Haseltine
PRINCIPAL_INVESTIGATOR
Site Public Contact
Mary E. Westerman
PRINCIPAL_INVESTIGATOR
Site Public Contact
Michael Siedow
PRINCIPAL_INVESTIGATOR
Site Public Contact
Tyler Gunter
PRINCIPAL_INVESTIGATOR
Site Public Contact
Heath B. Mackley
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Adam Olson
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Hyma Polimera
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Site Public Contact
Alexander P. Lukez
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Site Public Contact
Christopher Luminais
PRINCIPAL_INVESTIGATOR
Site Public Contact
Joseph D. Pennington
PRINCIPAL_INVESTIGATOR
Site Public Contact
Site Public Contact
Joanna A. Kolodney
PRINCIPAL_INVESTIGATOR
Site Public Contact
Bevan Ly
PRINCIPAL_INVESTIGATOR
Site Public Contact
Fabio L. Cury
PRINCIPAL_INVESTIGATOR
Site Public Contact
Eric Vigneault
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/8/2026.
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