RecruitingPhase II/III🇵🇱 PolandEN originalHead and neck cancerMetastatic / advanced

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

Ficerafusp alfa is directed against two targets, Epidermal Growth Factor Receptor (EGFR) and Transforming Growth Factor beta (TGF-β). This study intends to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab versus placebo with pembrolizumab in 1L PD-L1-positive, recurrent or metastatic Head and Neck Squamous Cell Carcinoma (HNSCC).

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Wiek co najmniej 18 lat
  • Potwierdzony w badaniu histopatologicznym rak płaskonabłonkowy głowy i szyi, który się rozprzestrzeniał lub powrócił
  • Brak wcześniejszego leczenia chemioterapią w przypadku choroby zaawansowanej
  • Posiadanie próbki guza do analizy laboratoryjnej lub zgoda na pobranie próbki
  • Określony marker w guzie (PD-L1 CPS ≥1)
  • Zmierzoną chorobę widoczną w badaniach obrazowych
  • Ogólny stan zdrowia pozwalający na leczenie (ECOG 0-1)
  • Prawidłowe funkcjonowanie nerek, wątroby i innych narządów

✗ Disqualifies

  • Nowotwór możliwy do wyleczenia operacją lub radioterapią
  • Wcześniejsze leczenie lekami anty-TGF-beta
  • Wcześniejsze leczenie przeciwciałami anty-EGFR
  • Ciężka alergiczna reakcja na poprzednie leczenie anty-EGFR
  • Leczenie inhibitorami immunologicznymi w ciągu ostatnich 6 miesięcy
  • Przerzuty do mózgu, zapalenie opon mózgowych lub uciśnięcie rdzenia kręgowego
  • Aktywne poważne krwawienie lub krwawienie w ostatnich 4 tygodniach
  • Spodziewana długość życia poniżej 3 miesięcy

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 17, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (203)

Site # 0137

Birmingham, United States

Site #0147

Phoenix, United States

Site #0107

La Jolla, United States

Site #0106

Los Angeles, United States

Site#0144

Sacramento, United States

Site #0130

San Francisco, United States

Site #0150

Stanford, United States

Site #0122

Aurora, United States

Site #0124

Aurora, United States

Site#0121

Aurora, United States

Site #0148

Jacksonville, United States

Site #0136

Palm Bay, United States

Site #0105

Tampa, United States

Site#0140

Iowa City, United States

Site #0149

Westwood, United States

Site#0111

Louisville, United States

Site#0115

Louisville, United States

Site #0112

Baltimore, United States

Site #0131

Boston, United States

Site#0101

Boston, United States

Site #0156

Maplewood, United States

Site #0146

Rochester, United States

Site #0114

St Louis, United States

Site #0145

Newark, United States

Site #0155

New York, United States

Site#0142

New York, United States

Site#0118

Durham, United States

Site#0154

Canton, United States

Site#0117

Cincinnati, United States

Site #0151

Cleveland, United States

Site #0108

Cleveland, United States

Site #0113

Portland, United States

Site #0103

Pittsburgh, United States

Site #0123

Pittsburgh, United States

Site #0132

Providence, United States

Site#0104

Charleston, United States

Site#0126

Nashville, United States

Site #0116

Nashville, United States

Site#0102

Houston, United States

Site #0152

Waco, United States

Site#0134

Charlottesville, United States

Site #0129

Richmond, United States

Site #0138

Richmond, United States

Site # 0160

Edmonds, United States

Site # 0159

Seattle, United States

Site #0125

Seattle, United States

Site#0120

Vancouver, United States

Site #0141

Madison, United States

Site #0157

Madison, United States

Site # 0153

Milwaukee, United States

Site # 2301

Buenos Aires, Argentina

Site # 2306

Buenos Aires, Argentina

Site # 2303

Pilar, Argentina

Site # 2305

Rosario, Argentina

Site # 2302

Santa Fe, Argentina

Site#0302

Camperdown, Australia

Site #0306

Kingswood, Australia

Site#0304

Waratah, Australia

Site #0305

Southport, Australia

Site#0307

Tugun, Australia

Site #0303

Heidelberg, Australia

Site#0301

North Melbourne, Australia

Site#0308

Murdoch, Australia

Site #1602

Salzburg, Austria

Site #1601

Vienna, Austria

Site #1007

Bruges, Belgium

Site #1005

Mons, Belgium

Site #1002

Namur, Belgium

Site #1003

Namur, Belgium

Site #1001

Sint-Niklaas, Belgium

Site #1006

Wilrijk, Belgium

Site # 2420

Santa Cecília, Brazil

Site # 2413

Barretos, Brazil

Site # 2404

Curitiba, Brazil

Site # 2402

Ijuí, Brazil

Site # 2411

Jaú, Brazil

Site # 2422

Natal, Brazil

Site # 2419

Passo Fundo, Brazil

Site # 2412

Rio de Janeiro, Brazil

Site # 2415

Santa Cruz do Sul, Brazil

Site # 2401

Santa Lúcia, Brazil

Site # 2406

São José do Rio Preto, Brazil

Site # 2405

São Paulo, Brazil

Site # 2416

São Paulo, Brazil

Site #0202

Vancouver, Canada

Site #0203

Montreal, Canada

Site # 0204

Toronto, Canada

Site # 2101

Hradec Králové, Czechia

Site #2102

Prague, Czechia

Site #0809

Amiens, France

Site # 0812

Bordeaux, France

Site # 0804

Lille, France

Site #0810

Lyon, France

Site # 0813

Paris, France

Site #0805

Rennes, France

Site #0807

Saint-Grégoire, France

Site #0808

Strasbourg, France

Site # 0811

Toulouse, France

Site #0806

Vandœuvre-lès-Nancy, France

Site #0801

Villejuif, France

Site #0710

Aachen, Germany

Site # 0701

Berlin, Germany

Site # 0714

Berlin, Germany

Site # 0709

Braunschweig, Germany

Site # 0705

Chemnitz, Germany

Site #0707

Dresden, Germany

Site # 0711

Dresden, Germany

Site #0706

Düsseldorf, Germany

Site # 0716

Essen, Germany

Site # 0708

Göttingen, Germany

Site # 0718

Hanover, Germany

Site #0717

Karlsruhe, Germany

Site # 0715

München, Germany

Site # 0703

Stuttgart, Germany

Site # 0702

Ulm, Germany

Site # 1701

Athens, Greece

Site # 1702

Larissa, Greece

Site # 3002

Sūrat, India

Site # 0603

Cork, Ireland

Site #0602

Dublin, Ireland

Site #0601

Dublin, Ireland

Site # 1903

Jerusalem, Israel

Site # 1902

Tel Aviv, Israel

Site #0904

Bologna, Italy

Site #0911

Florence, Italy

Site #0907

Milan, Italy

Site #0901

Milan, Italy

Site #0905

Milan, Italy

Site # 0912

Milan, Italy

Site # 0916

Naples, Italy

Site #0915

Naples, Italy

Site # 0910

Padova, Italy

Site #0908

Palermo, Italy

Site # 0903

Pavia, Italy

Site # 0909

Pisa, Italy

Site #0917

Rome, Italy

Site #0918

Rome, Italy

Site #0906

Rome, Italy

Site # 0919

Rozzano, Italy

Site # 0902

Siena, Italy

Site # 2802

George Town, Malaysia

Site # 2803

Kuala Lumpur, Malaysia

Site # 2805

Kuala Lumpur, Malaysia

Site # 2801

Kuching, Malaysia

Site # 2804

Pulau Pinang, Malaysia

Site #0401

Christchurch, New Zealand

Site#0402

Rotorua, New Zealand

Site #1401

Gdansk, Poland

Site # 1405

Gliwice, Poland

Site #1403

Katowice, Poland

Site #1407

Konin, Poland

Site #1404

Krakow, Poland

Site #1402

Siedlce, Poland

Site #1406

Warsaw, Poland

Site #1506

Braga, Portugal

Site #1503

Coimbra, Portugal

Site #1508

Lisbon, Portugal

Site #1501

Portimão, Portugal

Site #1505

Porto, Portugal

Site #1507

Porto, Portugal

Site #1502

Senhora da Hora, Portugal

Site # 1504

Vila Nova de Gaia, Portugal

Site # 2902

Novena, Singapore

Site # 2901

Singapore, Singapore

Site # 2707

Busan, South Korea

Site # 2704

Goyang-si, South Korea

Site # 2705

Hwasun, South Korea

Site # 2706

Seongnam, South Korea

Site # 2701

Seoul, South Korea

Site # 2702

Seoul, South Korea

Site # 1311

Badalona, Spain

Site #1301

Barcelona, Spain

Site #1305

Barcelona, Spain

Site #1304

Barcelona, Spain

Site # 1302

Barcelona, Spain

Site #1310

Madrid, Spain

Site #1303

Madrid, Spain

Site #1306

Pamplona, Spain

Site #1309

Santander, Spain

Site #1307

Valencia, Spain

Site #1308

Valencia, Spain

Site # 1803

Fribourg, Switzerland

Site # 1802

Geneva, Switzerland

Site # 1801

Lausanne, Switzerland

Site # 2602

Changhua, Taiwan

Site # 2601

Kaohsiung City, Taiwan

Site # 2603

Taichung, Taiwan

Site # 2604

Taipei, Taiwan

Site # 1201

Ankara, Turkey (Türkiye)

Site #0504

Aberdeen, United Kingdom

Site #0512

Birmingham, United Kingdom

Site #0513

Cambridge, United Kingdom

Site # 0510

Glasgow, United Kingdom

Site #0511

Leeds, United Kingdom

Site #0507

Liverpool, United Kingdom

Site #0505

London, United Kingdom

Site #0502

London, United Kingdom

Site #0508

Manchester, United Kingdom

Site #0506

Middlesex, United Kingdom

Site #0503

Nottingham, United Kingdom

Site #0515

Oxford, United Kingdom

Site # 0514

Portsmouth, United Kingdom

Site # 0501

Sutton, United Kingdom

Trial contact

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/10/2026.

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