ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Dorośli pacjenci (18 lat lub starsi) mający przejść operację usunięcia trzustki
- •Potwierdzony lub podejrzewany rak głowy trzustki, cholangiorak dystalne lub rak brodawki Vatera
- •Wysoki kliniczny risk powikłań (wycieku) ze szczęścia trzustki potwierdzona obrazami (CT, MRI lub USG endoskopowym)
- •Wyrażona pisemna zgoda na udział w badaniu
✗ Disqualifies
- •Rak dwunastnicy, ampularny typ jelitowy, nowotwory neuroendokrynne lub łagodne
- •Stan zdrowia uniemożliwiający pełne zrozumienie istoty badania
- •Ciąża lub potencjalna ciąża (test ciążowy będzie wymagany)
- •Niemożność uczestniczenia w badaniu z powodów psychicznych lub zaburzeń poznawczych
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (10)
Department of General, Visceral and Transplantation Surgery, University Hospital Münster
Münster, Germany
Department of General and Visceral Surgery, University Hospital Ulm
Ulm, Germany
Department of General and Visceral Surgery, Kantonsspital Aarau
Aarau, Switzerland
Department of Surgery, Kantonsspital Baden
Baden, Switzerland
Department of Visceral Surgery, University Hospital Basel
Basel, Switzerland
Inselspital, Bern University Hospital
Bern, Switzerland
Department of Visceral Surgery, University Hospital Geneva
Geneva, Switzerland
Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Department of Surgery, Stadtspital Triemli Zürich
Zurich, Switzerland
Department of Surgery and Transplantation, University Hospital Zürich
Zurich, Switzerland
Trial contact
Anna S Wenning, MD, PhD
Nadine Uebersax
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/22/2026.
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