Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of this clinical trial is to compare adverse even rates after EMR for large (≥20mm) flat colorectal polyps (so-called laterally spreading lesions, LSLs) when performing complete or no defect closure. It will also evaluate lesion recurrence after EMR for large colorectal LSLs. The hypothesis is that performing complete defect closure following EMR of large colorectal LSLs will result in lower rates of adverse events compared to cases where no defect closure is performed. For participants with planned EMR, endoscopists will perform EMRs as per standard of care and: * prophylactic defect closure will either not be performed (control group), or will be performed (experimental group); * then, patients will be called between 14 and 44 days after EMR to assess for possible adverse events, and electronic medical files will be verified for emergency room visits and healthcare received for an adverse event; * finally, patients will undergo follow-up colonoscopy 6 months and 18 months after randomization.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej
- •Zaplanowana operacja usunięcia dużego polipa jelita grubego (co najmniej 20 mm)
- •Wyrażona pisemna zgoda na udział w badaniu
✗ Disqualifies
- •Choroba zapalna jelit
- •Poważne problemy ogólne ze zdrowiem
- •Zaburzenia krzepnięcia krwi lub niedobór płytek krwi
- •Polip na szypule
- •Podejrzenie głębokich zmian nowotworowych
- •Ciąża
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 11, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Centre Hospitalier de l'Université de Montréal
Montreal, Canada
Trial contact
Daniel von Renteln, MD
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/12/2026.
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