Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a first in human study of TNG456 alone and in combination with abemaciclib in patients with advanced or metastatic solid tumors known to have an MTAP loss. The first part of the study is an open-label, dose escalation and the second part is an open label dose expansion in specific solid tumor types with a confirmed MTAP loss. The study drug, TNG456, is a selective PRMT5 inhibitor administered orally. The study is planned to treat up to 191 participants.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Nowotwór z potwierdzonym brakiem genu MTAP
- •Wiek co najmniej 18 lat
- •Brak odpowiedzi na standardowe leczenie lub nietolerancja istniejących terapii
- •Zdolność połykania tabletek
- •Prawidłowe funkcjonowanie organów wewnętrznych
- •Ujemny test ciąży (dla kobiet)
- •Stan sprawności 0-1 wg skali ECOG
- •Mierzalna choroba lub glejak z widocznym postępem
✗ Disqualifies
- •Ciąża lub karmienie piersią
- •Zaburzenia wchłaniania leków doustnych
- •Aktywna infekcja wymagająca leczenia
- •Wcześniejsze leczenie inhibitorami PRMT5 lub MAT2A
- •Wcześniejsze leczenie inhibitorami CDK4/6 (dla części badania)
- •Poważne choroby sercowo-naczyniowe
- •Inne przewlekłe choroby mogące wpływać na bezpieczeństwo
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (15)
Mayo Clinic Scottsdale
Scottsdale, United States
University of California, Irvine
Irvine, United States
University of California Los Angeles
Los Angeles, United States
University of California at San Francisco
San Francisco, United States
Sibley Memorial Hospital
Washington D.C., United States
Mayo Clinic Jacksonville
Jacksonville, United States
Northwestern Memorial Hospital
Chicago, United States
Dana Farber Cancer Institute
Boston, United States
Mayo Clinic Cancer Center
Rochester, United States
NYU Langone Health
New York, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Ohio State University Comprehensive Cancer Center
Columbus, United States
MD Anderson Cancer Center
Houston, United States
University of Utah, Huntsman Cancer Institute
Salt Lake City, United States
NEXT Virginia
Fairfax, United States
Trial contact
Adam Crystal, MD, PhD
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/17/2026.
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