Testing the Addition of an Anti-cancer Drug, Sapanisertib, to the Usual Chemotherapy Treatment (Cabozantinib) in Metastatic Liver Cell Cancer With a Change in Genes for the Protein β-Catenin, The SAPHIRE Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I/II trial studies the side effects and best dose of sapanisertib when given together with cabozantinib, and to see how well they work in treating patients with liver cancer that has spread from where it first started to other places in the body (metastatic) and contains a mutation (change) in the β-catenin gene. Sapanisertib and cabozantinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving sapanisertib and cabozantinib together may work better than giving cabozantinib alone in treating β-catenin-mutated metastatic hepatocellular carcinoma.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie lub cytologicznie rak wątroby, który nie może być wyleczony operacyjnie
- •Wiek co najmniej 18 lat
- •Wcześniejsze otrzymanie przynajmniej jednej linii leczenia systemowego dla nowotworu rozprzestrzenionego
- •Mutacja genu β-catenin potwierdzona badaniem genetycznym (NGS)
- •Dobry ogólny stan zdrowia (ECOG status ≤ 2)
- •Wyniki badań krwi spełniające określone normy (neutrofile, płytki, bilirubina, enzymy wątroby, nerkowe)
✗ Disqualifies
- •Wiek poniżej 18 lat
- •Pacjenci z poważnymi zaburzeniami czynności wątroby (Child Pugh > A)
- •Ostre wirusowe zapalenie wątroby bez leczenia
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 24, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (4)
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, United States
Oregon Health and Science University
Portland, United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, United States
Trial contact
Site Public Contact
April Choi
PRINCIPAL_INVESTIGATOR
Site Public Contact
Emerson Y. Chen
PRINCIPAL_INVESTIGATOR
Site Public Contact
Anwaar Saeed
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/26/2026.
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