Tarlatamab for Advanced Extrapulmonary Small Cell Carcinoma and Neuroendocrine Carcinoma (TAURUS)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Extrapulmonary small cell carcinoma (EPSCC) or neuroendocrine carcinoma (NEC) is a rare but fatal disease. The prognosis of patients with advanced EPSCC or NEC failed platinum-etoposide chemotherapy is poor with median overall survival ranged 6 to 9 months. High expression levels of DLL3 has been demonstrated in many EPSCC or NEC. As tarlatamab, a bispecific T-cell engager with dual affinity for DLL3 on tumor cells and CD3 on T cells, has demonstrated clinically meaningful activity for patients with advanced small cell lung cancer. We thus hypothesize that tarlatamab also has clinically activity for patients with advanced EPSCC and NECs.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Zgoda na udział w badaniu
- •Wcześniejsza nieudana chemioterapia na bazie platyny
- •Potwierdzony diagnozą rak neuroendokrynny z różnych miejsc w organizmie
- •Widoczne zmiany nowotworu w badaniach obrazowych z ostatnich 28 dni
- •Ogólny stan zdrowia pozwalający na leczenie (ECOG 0 lub 1)
- •Wiek co najmniej 18 lat
- •Chęć dostarczenia próbki guza lub poddania się biopsji
- •Prawidłowe funkcje narządów, w tym krew i krzepnięcie
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 17, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan
Trial contact
Jhe-Cyuan Guo
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/18/2026.
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