A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a Phase II, single-arm, multicenter trial for patients with metastatic non-small cell lung cancer who have brain metastases and no known actionable mutations. Eligible patients will receive a combination of Datopotamab-deruxtecan, Carboplatin, and Pembrolizumab every three weeks for four cycles, followed by maintenance therapy with Datopotamab-deruxtecan and Pembrolizumab until disease progression or intolerable toxicity. Patients with intracranial progression but no systemic progression may receive stereotactic radiosurgery and continue treatment based on the investigator's decision.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony niepłaskokomórkowy rak płuca z przerzutami do mózgu
- •Wynik badania PD-L1 poniżej 50%
- •Negatywne wyniki testów genetycznych na mutacje EGFR i ALK
- •Brak wcześniejszego leczenia systemowego dla zaawansowanego raka płuca
- •Mierzalne przerzuty do mózgu (co najmniej jeden guz o rozmiarze ≥10 mm)
- •Mierzalne ogniska choroby poza mózgiem
- •Wyrażona świadoma zgoda na uczestnictwo w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- August 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (13)
CRIO - Centro Regional Integrado de Oncologia
Fortaleza, Brazil
Santa Casa de Misericórdia da Bahia - Hospital Santa Izabel (Oncoclínicas)
Salvador, Brazil
Oncocentro de Minas Gerais (Oncoclínicas)
Belo Horizonte, Brazil
IMIP - Instituto de Medicina Integral Professor Fernando Figueira
Recife, Brazil
CTTB - Centro de Tratamento de Tumores Botafogo (Oncoclínicas)
Rio de Janeiro, Brazil
Liga Norte Riograndense Contra o Câncer
Natal, Brazil
ISCMPA - Santa Casa de Porto Alegre
Porto Alegre, Brazil
CPO - Centro de Pesquisa em Oncologia do Hospital São Lucas da PUCRS
Porto Alegre, Brazil
Catarina Pesquisa Clínica - Clínica de Neoplasias Litoral
Itajaí, Brazil
Hospital de Amor de Barretos
Barretos, Brazil
FUNFARME - Hospital de Base de São José do Rio Preto
São José do Rio Preto, Brazil
A.C. Camargo Cancer Center
São Paulo, Brazil
CPO - Centro Paulista de Oncologia (Oncoclínicas)
São Paulo, Brazil
Trial contact
Project Manager
Laura Voelcker
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/15/2026.
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