Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase I trial studies the side effects and best dose of papaverine (PPV) when given together with radiation therapy (RT) and tests how well it works in treating patients with rectal cancer that has spread to nearby tissue or lymph nodes (locally advanced). PPV is an enzyme inhibitor, and it may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. RT uses high energy x-rays, particles, or radioactive seeds to kill tumor cells and shrink tumors. Giving PPV with RT may be safe, tolerable, and/or effective in treating patients with locally advanced rectal cancer.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony nowotwór złośliwy odbytnicy (gruczolakorak)
- •Rak zaawansowany lokalnie (rozprzestrzeniło się na okoliczne tkanki lub węzły chłonne)
- •Chęć leczenia bez operacji chirurgicznej po zakończeniu terapii wstępnej
- •Prawidłowe wyniki badań krwi (białe krwinki, płytki, hemoglobina, wątroba, nerki)
- •Możliwość uczestnictwa w dodatkowych badaniach (MRI, pobieranie próbek tkanki, krwi i stolca)
- •Nowotwór o określonym typie molekularnym (MSS - stabilny mikrosatellitowo)
- •Dla pacjentów z wirusem HIV/zapalenia wątroby: kontrolowana infekcja i niezakaźne wirusowo
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 22, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
City of Hope Medical Center
Duarte, United States
Trial contact
Terence M. Williams
Terence M. Williams
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/23/2026.
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