CER-1236 in Patients With Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Myelofibrosis (MF)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is a first in human, multi center, open label, phase 1/1b study to evaluate the safety and preliminary efficacy of CER-1236 in patients with relapsed/refractory (R/R), measurable residual disease (MRD) positive acute myeloid leukemia (AML), or TP53mut disease.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzona diagnoza białaczki szpikowej (AML) lub zespołu mielodysplastycznego (MDS/AML) z 10-19% zmienonych komórek
- •Liczba limfocytów we krwi powyżej określonego poziomu przed procedurą aperezy
- •Ogólny stan zdrowia oceniony jako bardzo dobry lub dobry (ECOG 0-1)
✗ Disqualifies
- •Poprzednia terapia genetycznie zmodyfikowanymi komórkami
- •Brak mierzalnych zmian białaczki w badaniu szpiku przed началem leczenia
- •Aktywna choroba autoimmunologiczna lub jej historia w ciągu ostatnich 2 lat (z wyjątkami)
- •Alergia na fludarabinę, cyklofosfamid lub składniki leku
- •Pierwotny niedobór odporności
- •Inne warunki medyczne zagrażające bezpieczeństwu lub udziałowi w badaniu
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 85 Years
- Last updated (source)
- August 21, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (4)
University of California, Davis Comprehensive Cancer Center
Sacramento, United States
Colorado Blood Cancer Institute
Denver, United States
Sarah Cannon Research Insitute
Nashville, United States
The University of Texas MD Anderson Cancer Center
Houston, United States
Trial contact
Brian Jonas, MD
Alpha Stem Cell Clinic
Brian Jonas, MD
PRINCIPAL_INVESTIGATOR
Maris Michael, MD
Michael Maris, MD
PRINCIPAL_INVESTIGATOR
AskSarah Help Line Have Cancer Questions? askSARAH | Sarah Cannon
Abhishek Maiti, MD
Abhishek Maiti, MD
PRINCIPAL_INVESTIGATOR
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/22/2026.
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