A Clinical Study of Raludotatug Deruxtecan in People With Ovarian Cancer (MK-5909-003)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for other ways to treat relapsed high-grade serous ovarian cancer. Relapsed means the cancer came back after treatment. High-grade means the cancer cells grow and spread quickly. Serous means the cancer started in the cells that cover the ovaries, the lining of the belly, or in the fallopian tubes. Standard treatment (usual treatment) for people with relapsed high-grade serous ovarian cancer may include: * Chemotherapy, which is a treatment that uses medicine to destroy cancer cells or stop them from growing * Targeted therapy, which is a treatment that works to control how specific types of cancer cells grow and spread Raludotatug deruxtecan (R-DXd) is a study treatment that is an antibody drug conjugate (ADC). An ADC attaches to a protein on cancer cells and delivers treatment to destroy those cells. Researchers want to know if R-DXd is safe to take with other treatments and if people tolerate them together. They also want to learn how many people have the cancer respond (gets smaller or goes away) to the treatments.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony diagnostycznie rak jajnika, rak otrzewnej lub rak jajowodu, który szybko rośnie
- •Widoczne nowotwory widoczne na badaniach obrazowych
- •Rak powrócił po 1-3 liniach poprzedniego leczenia
- •Biopsia potwierdzająca typ nowotworu
- •Dobry ogólny stan zdrowia (zdolność do pełnienia normalnych czynności)
- •Jeśli pacjent ma HIV, musi być ono kontrolowane lekami
- •Jeśli pacjent ma zapalenie wątroby, wirus musi być niewykrywalny lub kontrolowany
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 17, 2026
- Sex
- Female only
Therapies / drugs in trial
Locations (28)
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0019)
New Haven, United States
The University of Louisville, James Graham Brown Cancer Center ( Site 0009)
Louisville, United States
Dana-Farber Cancer Institute ( Site 0015)
Boston, United States
Memorial Sloan Kettering Cancer Center ( Site 0003)
New York, United States
OU Health University of Oklahoma Medical Center ( Site 7000)
Oklahoma City, United States
Texas Oncology - DFW ( Site 8000)
Fort Worth, United States
Houston Methodist Hospital ( Site 0010)
Houston, United States
START Mountain Region ( Site 0008)
West Valley City, United States
University of Virginia Health System ( Site 0011)
Charlottesville, United States
McGill University Health Centre ( Site 0100)
Montreal, Canada
Rambam Health Care Campus ( Site 0202)
Haifa, Israel
Shaare Zedek Medical Center ( Site 0201)
Jerusalem, Israel
Rabin Medical Center ( Site 0203)
Petah Tikva, Israel
Sheba Medical Center ( Site 0200)
Ramat Gan, Israel
Institut Català d'Oncologia - L'Hospitalet ( Site 0302)
L'Hospitalet de Llobregat, Spain
HOSPITAL UNIVERSITARIO PUERTA DE HIERRO MAJADAHONDA ( Site 0307)
Majadhonda, Spain
Clinica Universidad de Navarra ( Site 0301)
Madrid, Spain
Hospital General Universitario de Valencia ( Site 0305)
Valencia, Spain
Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0300)
Barcelona, Spain
Hospital Universitario Fundación Jiménez Díaz-START Madrid-FJD ( Site 0303)
Madrid, Spain
Hospital Universitario 12 de Octubre ( Site 0304)
Madrid, Spain
Hospital Universitario Virgen de la Victoria ( Site 0306)
Málaga, Spain
University Hospitals Sussex NHS Foundation Trust ( Site 0404)
Brighton, United Kingdom
Royal Marsden Hospital ( Site 0402)
Fulham, United Kingdom
The Royal Marsden NHS Foundation Trust. ( Site 0403)
Sutton, United Kingdom
Barts Health NHS Trust ( Site 0401)
London, United Kingdom
Guy s & St Thomas NHS Foundation Trust ( Site 0400)
London, United Kingdom
The Christie NHS Foundation Trust ( Site 0405)
Manchester, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/14/2026.
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