A Phase 2 Study of PTX 100 in Patients With Relapsed/Refractory CTCL
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This is an open-label, phase 2 randomized study to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmadynamics (PD), of PTX-100 monotherapy at 500 or 1000 mg/m2 in patients with relapsed/refractory Cutaneous T-Cell Lymphoma (CTCL). PTX-100 will be administered by IV infusion over 60 minutes on days 1 to 5 of a 14-day cycle for 4 cycles, then 21 day cycle thereafter. Subjects will be treated or followed up, if subjects discontinue treatment, for up to 18 months.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzony rozpoznaniem chłoniaka T-komórkowego skóry (CTCL) na podstawie badania histologicznego
- •Zaawansowana choroba (co najmniej stadium Ib)
- •Brak odpowiedzi na co najmniej 2 poprzednie leczenia lub nietolerancja ich
- •Mierzalne ogniska choroby widoczne w badaniach
- •Zdrowe funkcje szpiku kostnego, wątroby i nerek
- •Ujemny wynik testu na HTLV-1
- •Oczekiwana długość życia co najmniej 3 miesiące
✗ Disqualifies
- •Aktualnie w ciąży lub karmieniu piersią
- •Dodatni wynik testu na HIV bez stabilnego leczenia lub z wiremią powyżej 400 kopii/mL
- •Niedawne leczenie przeciwnowotworowe (brak wymaganego okresu przerwy)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 9, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (15)
City of Hope Comprehensive Cancer Cente
Duarte, United States
University of California Irvine
Irvine, United States
Yale Cancer Center
New Haven, United States
Dana-Farber Cancer Institute
Boston, United States
Rochester Skin Lymphoma Medical Group. PLLC
Rochester, United States
Virginia Commonwealth University Massey Comprehensive Cancer Cente
Richmond, United States
Westmead Hospital
Westmead, Australia
Epworth Healthcare
Melbourne, Australia
Linear Clinical Research
Nedlands, Australia
CHU de Bordeaux - Hopital Saint André
Bordeaux, France
Hopital Lyon Sud
Lyon, France
Hopital Saint Louis
Paris, France
IRCCS Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi
Bologna, Italy
Universita degli Studi Di Brescia-Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Brescia, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele (HSR) (Istituto Scientifico Universitario San Raffaele)
Milan, Italy
Trial contact
Upaly Bahadure
David Wong
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/10/2026.
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