A Study of Navlimetostat (BMS-986504) Alone or in Combination With Izalontamab Brengitecan in Participants With Pre-treated Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) With Homozygous MTAP Deletion or MTAP Loss (MountainTAP-9)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The purpose of this study is to evaluate the safety and efficacy of Navlimetostat (BMS-986504) monotherapy or in combination with Izalontamab Brengitecan in participants with advanced or metastatic Non-small Cell Lung Cancer (NSCLC) with homozygous MTAP deletion or MTAP loss after progression on prior therapies.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony histologicznie rak płuca bez drobnych komórek z brakiem genu MTAP potwierdzonym w tkance nowotworu
- •Zaawansowany rak płuca przerzutowy, którego nie można wyleczyć chirurgicznie, przy wcześniejszym leczeniu
- •Co najmniej jedno zmierzone ognisko nowotworowe widoczne w badaniach obrazowych
- •Postęp choroby widoczny w badaniach obrazowych po ostatnim leczeniu
- •Ogólny stan zdrowia pozwalający na leczenie (skala ECOG 0-1)
- •Wiek co najmniej 18 lat
- •Zdolność połykania tabletek w całości
- •Dla grupy z kombinacją leków: znany status genu EGFR
✗ Disqualifies
- •Przerzuty do mózgu lub nowotwór opon mózgowych
- •Zaburzenia żołądka lub jelita mogące uniemożliwić przyjmowanie leków doustnych
- •Wcześniejsze leczenie lekami hamującymi PRMT5 lub MAT2A
- •Ciężka uczulenie na leki stosowane w badaniu
- •Dla grupy z kombinacją: wcześniejsze leczenie iza-bren lub podobnymi lekami skierowanymi na EGFR lub HER3
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 18, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (67)
Local Institution - 0088
Anchorage, United States
Dana-Farber Cancer Institute
Boston, United States
Karmanos Cancer Institute
Detroit, United States
Washington University School of Medicine
St Louis, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Gabrail Cancer Center
Canton, United States
Providence Portland Medical Center
Portland, United States
Oregon Health and Science University
Portland, United States
Fred Hutchison Cancer Center
Seattle, United States
Medical College of Wisconsin
Milwaukee, United States
GenesisCare - Campbelltown
Campbelltown, Australia
Chris O'Brien Lifehouse
Camperdown, Australia
Princess Alexandra Hospital
Woolloongabba, Australia
Local Institution - 0097
Adelaide, Australia
Beijing Chest Hospital,Capital Medical University
Beijing, China
The First Affiliated hospital of Xiamen University
Xiamen, China
Guangxi Medical University Affiliated Tumor Hospital
Nanning, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Shandong Cancer Hospital
Jinan, China
LinYi Cancer Hospital
Linyi, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, China
Taizhou Hospital of Zhejiang Province
Linhai, China
Chu Grenoble Alpes
La Tronche, France
Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
Saint-Herblain, France
Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois
Vandœuvre-lès-Nancy, France
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, France
Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, France
Institut Curie
Paris, France
Hôpital Tenon
Paris, France
Groupe hospitalier Paris saint Joseph
Paris, France
Klinikum der Ludwig-Maximilians-Universitaet Muenchen
München, Germany
Universitätsklinikum Frankfurt Goethe-Universität
Frankfurt am Main, Germany
Krankenhaus Martha-Maria Halle-Dölau
Halle, Germany
Universitaetsklinikum Koeln
Cologne, Germany
Universitaetsklinikum Wuerzburg
Würzburg, Germany
AOU della Campania Luigi Vanvitelli
Naples, Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale
Naples, Italy
Fondazione IRCCS San Gerardo dei Tintori
Monza, Italy
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy
Istituto Oncologico Veneto IRCCS
Padova, Italy
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
Bologna, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, Italy
National Cancer Center Hospital East
Kashiwa, Japan
Sendai Kousei Hospital
Sendai, Japan
Kansai Medical University Hospital
Hirakata, Japan
Mazowiecki Szpital Onkologiczny
Wieliszew, Poland
Szpital Specjalistyczny w Prabutach Spolka z o.o.
Prabuty, Poland
Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
Bucharest, Romania
SC Radiotherapy Center Cluj SRL
Florești, Romania
Centrul de Oncologie "Sfântul Nectarie"
Craiova, Romania
Centrul de Diagnostic si Tratament Provita
Bucharest, Romania
Institutul Oncologic Cluj
Cluj-Napoca, Romania
S.C. Centrul de Oncologie Euroclinic S.R.L.
Iași, Romania
Institutul Regional de Oncologie
Iași, Romania
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Institut Català d'Oncologia - L'Hospitalet
Hospitalet, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital Universitario 12 de Octubre
Madrid, Spain
Hospital Universitario La Paz
Madrid, Spain
H.R.U Málaga - Hospital General
Málaga, Spain
Hospital Universitario Virgen Del Rocio
Seville, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Karolinska Universitetssjukhuset Solna
Solna, Sweden
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden
Queen Elizabeth Hospital Birmingham
Birmingham, United Kingdom
Sarah Cannon Research Institute UK
London, United Kingdom
Freeman Hospital
Newcastle upon Tyne, United Kingdom
Trial contact
BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
First line of the email MUST contain NCT # and Site #.
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/19/2026.
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