A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Researchers are looking for ways to treat germinal center B-cell-like diffuse large B-cell lymphoma (GCB DLBCL). DLBCL is a fast-growing blood cancer that affects B-cells. GCB is a type of DLBCL that affects young B-cells that are still maturing. The goal of this study is to learn if more people who receive zilovertamab vedotin (MK-2140) and R-CHP have the cancer respond (go away) than those who receive polatuzumab vedotin and R-CHP.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Potwierdzony typ chłoniaka: rozlany chłoniak z dużych komórek B, typ GCB.
- •Choroba widoczna w badaniu PET.
- •Brak wcześniejszego leczenia chłoniaka.
- •Zakażeni wirusem HIV muszą mieć dobrze kontrolowane wirusy przyjmowanymi lekami.
- •Osoby zakażone wirusem zapalenia wątroby typu B muszą przyjmować leki i mieć niewykrywalną ilość wirusa.
- •Osoby po przebytym zapaleniu wątroby typu C muszą mieć niewykrywalną ilość wirusa.
✗ Disqualifies
- •Inny, łagodniejszy typ chłoniaka, który przekształcił się w rozlany chłoniak z dużych komórek B.
- •Inny rzadki typ chłoniaka (pierwotny śródpiersiowy chłoniak z dużych komórek B, chłoniak strefy szarej).
- •Chłoniak we wczesnym stadium (Ann Arbor I).
- •Znaczne problemy z sercem (np. niedawny zawał, niewydolność serca).
- •Płyn w osierdziu lub opłucnej.
- •Problem z nerwami obwodowymi (stopień 2 lub gorszy).
- •Nieleczona choroba Charcota-Mariego-Tootha.
- •Osoby zakażone wirusem HIV z przebytym mięsakiem Kaposiego lub chorobą Castlemana.
- •Przyjmowanie kortykosteroidów w trakcie.
- •Inny nowotwór, który się rozwija lub wymaga leczenia.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (133)
Infirmary Cancer Care ( Site 0157)
Mobile, United States
Ironwood Cancer & Research Centers ( Site 0204)
Chandler, United States
Palo Verde Cancer Specialists ( Site 0105)
Glendale, United States
City of Hope - Phoenix ( Site 0202)
Goodyear, United States
Genesis Cancer and Blood Institute ( Site 0193)
Hot Springs, United States
Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0135)
Burbank, United States
City of Hope Comprehensive Cancer Center ( Site 0191)
Duarte, United States
Bass Medical Group ( Site 0123)
Walnut Creek, United States
Rocky Mountain Cancer Centers (RMCC) ( Site 8001)
Aurora, United States
Colorado West Healthcare System-Grand Valley Oncology ( Site 0165)
Grand Junction, United States
Medical Oncology Hematology Consultants (MOHC) ( Site 8007)
Newark, United States
Georgetown University Medical Center ( Site 0117)
Washington D.C., United States
Boca Raton Regional Hospital-Lynn Cancer Institute ( Site 0130)
Boca Raton, United States
Baptist MD Anderson Cancer Center ( Site 0176)
Jacksonville, United States
Mount Sinai Braman Comprehensive Cancer Center ( Site 0140)
Miami Beach, United States
Mid Florida Hematology and Oncology Center ( Site 0152)
Orange City, United States
Beacon Cancer Care ( Site 0142)
Post Falls, United States
University of Chicago Medical Center ( Site 0126)
Chicago, United States
Illinois Cancer Care ( Site 7005)
Peoria, United States
University of Iowa-Holden Comprehensive Cancer Center ( Site 0139)
Iowa City, United States
Mission Blood & Cancer Care ( Site 0114)
Waukee, United States
Saint Elizabeth Medical Center Edgewood ( Site 0141)
Edgewood, United States
Baptist Health Hardin ( Site 0154)
Elizabethtown, United States
Baptist Health Lexington ( Site 0127)
Lexington, United States
Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0185)
Louisville, United States
Our Lady of the Lake Physician Group-Medical Oncology ( Site 0180)
Baton Rouge, United States
Ochsner LSU Health - Monroe Medical Center, Family Medicine Clinic ( Site 0209)
Monroe, United States
Ochsner Clinic Foundation ( Site 0189)
New Orleans, United States
Louisiana State University Health Sciences Shreveport ( Site 0195)
Shreveport, United States
Beth Israel Deaconess Medical Center ( Site 0161)
Boston, United States
Dana Farber Cancer Institute ( Site 0111)
Boston, United States
Minnesota Oncology Hematology (MNO) ( Site 8004)
Burnsville, United States
Bozeman Health Deaconess Hospital ( Site 0183)
Bozeman, United States
NHO Revive Research Institute, LLC ( Site 0121)
Lincoln, United States
University Of Nebraska Medical Center ( Site 0110)
Omaha, United States
Atlantic Health Morristown Medical Center ( Site 0163)
Morristown, United States
Valley Health Systems - Ridgewood Campus ( Site 0125)
Paramus, United States
Erie County Medical Center ( Site 0175)
Buffalo, United States
Roswell Park Cancer Institute ( Site 0192)
Buffalo, United States
Perlmutter Cancer Center at NYU Langone Hospital - Long Island ( Site 0208)
Mineola, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 0108)
New York, United States
SUNY Upstate Cancer Center ( Site 0178)
Syracuse, United States
Optum Medical Care, PC ( Site 0122)
Westbury, United States
University of North Carolina Medical Center ( Site 0136)
Chapel Hill, United States
Novant Health Presbyterian Medical Center ( Site 0177)
Charlotte, United States
Novant Health Forsyth Medical Center ( Site 0206)
Winston-Salem, United States
University of Cincinnati Medical Center ( Site 0156)
Cincinnati, United States
University Hospitals of Cleveland ( Site 0155)
Cleveland, United States
Fairview Hospital-Moll Cancer Center ( Site 0198)
Cleveland, United States
Cleveland Clinic Main ( Site 0101)
Cleveland, United States
Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0199)
Mayfield Heights, United States
Providence Portland Medical Center ( Site 0120)
Portland, United States
Providence Oncology and Hematology Clinic Westside ( Site 0179)
Portland, United States
Temple University Hospital ( Site 0133)
Philadelphia, United States
Alliance Cancer Specialists (ACS) ( Site 8010)
Sellersville, United States
Cancer Care Associates Of York ( Site 0174)
York, United States
Medical University of South Carolina ( Site 0153)
Charleston, United States
Tennessee Cancer Specialists ( Site 7004)
Knoxville, United States
SCRI Oncology Partners ( Site 7002)
Nashville, United States
Texas Oncology - West Texas ( Site 8008)
Amarillo, United States
Texas Oncology - Central/South Texas ( Site 8006)
Austin, United States
Texas Oncology - Northeast Texas ( Site 8002)
Palestine, United States
Texas Oncology - San Antonio ( Site 8009)
San Antonio, United States
The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0145)
Tyler, United States
Intermountain Medical Center ( Site 0182)
Murray, United States
Intermountain Healthcare - St. George ( Site 0203)
St. George, United States
Virginia Cancer Specialists, PC ( Site 8003)
Manassas, United States
VCU Health Adult Outpatient Pavillion ( Site 0138)
Richmond, United States
Northwest Cancer Specialists (Compass Oncology) ( Site 8000)
Vancouver, United States
SSM Health Dean Medical Group ( Site 0106)
Madison, United States
Medical College of Wisconsin ( Site 0103)
Milwaukee, United States
AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 0306)
Mechelen, Belgium
CHU HELORA asbl ( Site 0304)
Mons, Belgium
Cliniques Universitaires Saint-Luc ( Site 0302)
Brussels, Belgium
VITAZ ( Site 0307)
Sint-Niklaas, Belgium
UZ Leuven ( Site 0301)
Leuven, Belgium
AZ Delta ( Site 0303)
Roeselare, Belgium
Klinikum Stuttgart. Klinik fur Hamatologie. Onkologie. Palliativmedizin und Stammzelltransplantation ( Site 0419)
Stuttgart, Germany
Uniklinik Erlangen ( Site 0412)
Erlangen, Germany
Universitaetsklinikum Wuerzburg ( Site 0401)
Würzburg, Germany
Centrum für Hämatologie und Onkologie Bethanien ( Site 0417)
Frankfurt am Main, Germany
KRH Klinikum Siloah ( Site 0441)
Hanover, Germany
Dietrich Bonhoeffer Klinikum-Neubrandenburg ( Site 0439)
Neubrandenburg, Germany
HELIOS Klinikum Wuppertal ( Site 0435)
Wuppertal, Germany
Klinikum Chemnitz gGmbH ( Site 0405)
Chemnitz, Germany
Otto-Von-Guericke-Universitaet Magdeburg ( Site 0411)
Magdeburg, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck ( Site 0425)
Lübeck, Germany
Universitätsklinikum Jena ( Site 0438)
Jena, Germany
St Vincent's University Hospital ( Site 0502)
Dublin, Ireland
Mater Misercordiae University Hospital ( Site 0501)
Dublin, Ireland
University Hospital Limerick ( Site 0503)
Limerick, Ireland
Soroka Medical Center ( Site 0606)
Beersheba, Israel
Rambam Health Care Campus ( Site 0604)
Haifa, Israel
Edith Wolfson Medical Center ( Site 0602)
Holon, Israel
Haddasah Medical Center ( Site 0601)
Jerusalem, Israel
Rabin Medical Center ( Site 0607)
Petah Tikva, Israel
Sheba Medical Center ( Site 0603)
Ramat Gan, Israel
ZIV Medical Center ( Site 0605)
Safed, Israel
Sourasky Medical Center ( Site 0608)
Tel Aviv, Israel
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 0707)
Meldola, Italy
Istituto Clinico Humanitas ( Site 0704)
Rozzano, Italy
Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0703)
Alessandria, Italy
Istituto Europeo di Oncologia ( Site 0701)
Milan, Italy
Universita degli Studi di Napoli Federico II ( Site 0705)
Naples, Italy
Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 0702)
Palermo, Italy
Arcispedale Santa Maria Nuova ( Site 0706)
Reggio Emilia, Italy
Aichi Cancer Center ( Site 1007)
Nagoya, Japan
Fujita Health University Hospital ( Site 1003)
Toyoake, Japan
Hokkaido University Hospital ( Site 1004)
Sapporo, Japan
National Hospital Organization Sendai Medical Center ( Site 1005)
Sendai, Japan
Kansai Medical University Hospital ( Site 1006)
Hirakata, Japan
Shimane University Hospital ( Site 1002)
Izumo, Japan
Nippon Medical School Hospital ( Site 1001)
Bunkyo, Japan
National Cancer Center Hospital ( Site 1009)
Chūō, Japan
Nagasaki University Hospital ( Site 1008)
Nagasaki, Japan
Pratia MCM Krakow ( Site 0804)
Karkow, Poland
Szpital Specjalistyczny im. Jedrzeja Sniadeckiego w Nowym Saczu ( Site 0806)
Nowy Sącz, Poland
Specjalistyczny Szpital im. Dr Alfreda Sokolowskiego w Walbrzychu ( Site 0807)
Wałbrzych, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0803)
Warsaw, Poland
Uniwersyteckie Centrum Kliniczne ( Site 0802)
Gdansk, Poland
Pratia Onkologia Katowice ( Site 0801)
Katowice, Poland
Bristol Haematology and Oncology Centre ( Site 0908)
Bristol, United Kingdom
Stoke Mandeville Hospital ( Site 0917)
Aylesbury, United Kingdom
Royal Devon & Exeter Hospital ( Site 0910)
Exeter, United Kingdom
University Hospitals Plymouth NHS Trust ( Site 0905)
Plymouth, United Kingdom
The James Cook University Hospital ( Site 0909)
Middlesbrough, United Kingdom
Lincoln County Hospital ( Site 0906)
Lincoln, United Kingdom
Guy s & St Thomas NHS Foundation Trust ( Site 0904)
London, United Kingdom
Hammersmith Hospital ( Site 0915)
London, United Kingdom
Churchill Hospital ( Site 0903)
Oxford, United Kingdom
Queen Elizabeth Hospital Birmingham ( Site 0912)
Birmingham, United Kingdom
Clatterbridge Cancer Centre - Liverpool ( Site 0911)
Liverpool, United Kingdom
Christie Hospital NHS Trust ( Site 0901)
Manchester, United Kingdom
Trial contact
Toll Free Number
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.