A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This study aims to investigate the combination of BNT324, a B7-H3 antibody-drug conjugate (ADC) with BNT327, a programmed death-ligand 1 (PD-L1) and vascular endothelial growth factor (VEGF) bispecific antibody, in participants with advanced/metastatic or relapsed/progressive small cell lung cancer (SCLC) and non small cell lung cancer (NSCLC).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek co najmniej 18 lat
- •Potwierdzona histologicznie zaawansowana lub przerzutowa rak płuc, którego nie można operować
- •Możliwość zmierzenia wielkości guza
- •Ogólny stan zdrowia pozwalający na leczenie (skala 0-1)
- •Przewidywana długość życia co najmniej 12 tygodni
- •Wcześniejsze leczenie wymagane dla niektórych typów guza
✗ Disqualifies
- •Poprzednie leczenie B7-H3 - rodzajem terapii celowanej
- •Poprzednie leczenie określonymi lekami chemii (ADC z inhibitorami topoisomerazy) - z wyjątkami dla pacjentów po wcześniejszych liniach terapii
- •Możliwość przeprowadzenia operacji lub radioterapii, która mogłaby całkowicie wyleczyć raka
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 16, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (88)
Mayo Clinic Arizona
Phoenix, United States
Precision NextGen Oncology and Research Center
Beverly Hills, United States
Cedars Sinai Medical Center
Los Angeles, United States
UCLA - David Geffen School of Medicine
Santa Monica, United States
University of Colorado Cancer Center
Aurora, United States
Mayo Clinic in Florida
Jacksonville, United States
University of Iowa Hospitals & Clinics PARENT
Iowa City, United States
Mayo Clinic-Rochester
Rochester, United States
John Theurer Cancer Center at Hackensack UMC
Hackensack, United States
Memorial Sloan Kettering Cancer Center (MSKCC)
New York, United States
Icahn School of Medicine at Mount Sinai PRIME
New York, United States
Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center
Cleveland, United States
Texas Oncology - DFW
Dallas, United States
MD Anderson Cancer Center
Houston, United States
Texas Oncology - Northeast
Tyler, United States
Virginia Cancer Specialists
Fairfax, United States
Chris O'Brien Lifehouse
Camperdown, Australia
Flinders Medical Centre
Bedford Park, Australia
Bendigo Hospital
Bendigo, Australia
Barwon Health
Geelong, Australia
Sunshine Hospital
Saint Albans, Australia
St John of God Subiaco Hospital
Subiaco, Australia
Anhui Provincial Cancer Hospital
Hefei, China
Beijing Cancer Hospital
Beijing, China
Beijing GoBroad Hospital
Beijing, China
Fujian Medical University Union Hospital
Fuzhou, China
Fujian Cancer Hospital
Fuzhou, China
Guangxi Medical University Cancer Hospital
Nanning, China
The First Affiliated Hospital of Xinxiang Medical University
Weihui, China
Henan Provincial Cancer Hospital
Zhengzhou, China
Jingzhou First People's Hospital
Jingzhou, China
Xiangyang Central Hospital
Xiangyang, China
Yichang Central People's Hospital
Yichang, China
Hunan Province People's Hospital
Changsha, China
Nanjing Chest Hospital
Nanjing, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Jiangxi Cancer Hospital
Nanchang, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
Jilin Cancer Hospital
Changchun, China
Linyi Cancer Hospital
Shandong, China
The First Affiliated Hospital of Xian Jiaotong University
Xi'an, China
Jinan Central Hospital
Jinan, China
Shandong Cancer Hospital
Jinan, China
Shanghai GoBroad Cancer Hospital
Shanghai, China
West China Hospital, Sichuan University
Chengdu, China
First Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, China
Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
Hangzhou, China
Zhejiang Cancer Hospital
Hangzhou, China
The First Affiliated Hospital of Xiamen University
Fujian, China
Affiliated Cancer Hospital and Institute of Guangzhou Medical University
Guandong, China
Xuzhou Central Hospital
Xuzhou, China
Centre Hospitalier Intercommunal de Créteil
Créteil, France
Assistance Publique-Hôpitaux de Marseille
Marseille, France
Hôpital Foch
Suresnes, France
Hopital Larrey
Toulouse, France
IRCCS Istituto di Candiolo
Candiolo, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Istituto Nazionale Tumori Regina Elena IRCCS
Roma, Italy
Azienda Ospedaliera Universitaria Integrata Verona (Ospedale Borgo Roma)
Verona, Italy
Uniwersyteckie Centrum Kliniczne
Gdansk, Poland
Pratia Onkologia Katowice
Katowice, Poland
Centrum Medyczne Pratia Poznań
Poznan, Poland
Hospital Universitari Dexeus
Barcelona, Spain
Clinica Universidad de Navarra
Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Hospital Quironsalud Malaga
Málaga, Spain
Hospital Universitario Nuestra Señora de Valme
Seville, Spain
Hospital Universitario de Torrejón
Torrejón de Ardoz, Spain
Hospital Universitari i Politecnic La Fe
Valencia, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
National Taiwan University Cancer Center
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Adana City Hospital
Adana, Turkey (Türkiye)
Hacettepe University Medical Faculty
Ankara, Turkey (Türkiye)
Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital
Ankara, Turkey (Türkiye)
Ankara City Hospital
Ankara, Turkey (Türkiye)
Yeditepe University Medical School Hospital
Istanbul, Turkey (Türkiye)
Koc University Hospital
Istanbul, Turkey (Türkiye)
Sakarya Training and Research Hospital
Sakarya, Turkey (Türkiye)
Bristol Haematology and Oncology Centre
Bristol, United Kingdom
St. James's University Hospital
Leeds, United Kingdom
The Clatterbridge Cancer Center
Liverpool, United Kingdom
St George's Hospitals NHS Foundation Trust
London, United Kingdom
University College London Hospital
London, United Kingdom
The Christie NHS Foundation Trust
Manchester, United Kingdom
Trial contact
BioNTech clinical trials patient information
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/17/2026.
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