Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This clinical trial is designed to assess the efficacy and safety of trastuzumab deruxtecan (T-DXd; Enhertu®) in combination with pembrolizumab versus platinum-based chemotherapy in combination with pembrolizumab in participants with no prior therapy for locally advanced unresectable or metastatic non-squamous NSCLC, whose tumors have HER2-overexpressing and PD-L1 TPS \<50% without known AGA that have locally available therapies targeting their AGAs in first-line advanced/metastatic setting.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Pacjent musi mieć ukończone 18 lat.
- •Pacjent musi mieć potwierdzonego niedrobnokomórkowego raka płuca (nie-płaskonabłonkowego), który jest zaawansowany lub nieoperacyjny/z przerzutami (stadia IV, IIIB lub IIIC).
- •Guz pacjenta musi nadmiernie produkować białko HER2.
- •Guz pacjenta nie może mieć znanych mutacji, dla których istnieją dostępne terapie celowane.
- •Pacjent nie był wcześniej leczony systemowymi lekami przeciwnowotworowymi z powodu zaawansowanego lub przerzutowego raka płuca.
- •Pacjent wyraża zgodę na udział w badaniu.
✗ Disqualifies
- •Pacjenci, którzy byli leczeni za pomocą leków zawierających substancje czynne wpływające na enzym topoizomerazę I (np. niektóre chemioterapeutyki, leki typu ADC).
- •Pacjenci z mutacją HER2.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- July 2, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (160)
Alaska Oncology & Hematology, LLC
Anchorage, United States
Orange Coast Memorial Medical Center Fountain Valley
Fountain Valley, United States
California Research Institute
Los Angeles, United States
Los Angeles Cancer Network (LACN)
Los Angeles, United States
Providence Medical Foundation
Santa Rosa, United States
Bay Pines VA Healthcare System
Bay Pines, United States
Lynn Cancer Institute Center
Boca Raton, United States
Holy Cross Hospital
Fort Lauderdale, United States
Mid-Florida Hematology & Oncology Centers, P.A.
Orange City, United States
BRCR Global Plantation
Plantation, United States
Hope and Healing Cancer Services
Hinsdale, United States
Dana-Farber Cancer Institute
Boston, United States
Logan Health Research
Kalispell, United States
Clinical Research Alliance
Westbury, United States
FirstHealth Cancer Center
Pinehurst, United States
Gabrail Cancer Center
Canton, United States
St. Charles Health System
Bend, United States
University of Texas M. D. Anderson Cancer Center
Houston, United States
Lumi Research
Kingwood, United States
Summit Cancer Treatment Center
Spokane, United States
CINME - Centro De Investigaciones Metabolicas
Buenos Aires, Argentina
Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
Instituto Argentino de Diagnostico y Tratamiento
Buenos Aires, Argentina
Instituto de Investigaciones Metabolicas (IDIM)
Buenos Aires, Argentina
Centro de Investigacion Pergamino SA
Pergamino, Argentina
Hospital Universitario Austral
Pilar, Argentina
Instituto de Oncologia de Rosario
Rosario, Argentina
Instituto Medico de la Fundacion Estudios Clinicos
Rosario, Argentina
Sanatorio Parque S.A.
Rosario, Argentina
Instituto San Marcos
San Juan, Argentina
Chu de Liăge
Liège, Belgium
CHU Helora-Hospital de Mons
Mons, Belgium
Hospital de Cancer de Barretos - Fundacao Pio XII
Barretos, Brazil
Centro de Pesquisas Clinica Reichow
Blumenau, Brazil
CIONC-Centro Integrado de Oncologia de Curitiba
Curitiba, Brazil
CRIO - Centro Regional Integrado de Oncologia
Fortaleza, Brazil
Liga Norte-Rio-Grandense Contra o Câncer
Natal, Brazil
Hospital Ernesto Dornelles
Porto Alegre, Brazil
Hospital Nossa Senhora Da Conceição
Porto Alegre, Brazil
Hospital São Lucas da PUCRS
Porto Alegre, Brazil
Centro de Tratamento Oncologico (CTO)
Ribeirão Preto, Brazil
Hospital das Clínicas FMRP-USP
Ribeirão Preto, Brazil
Instituto Dâor Pesquisa E Ensino - Rio de Janeiro
Rio de Janeiro, Brazil
Obras Sociais Irmã Dulce - Hospital Santo Antônio
Salvador, Brazil
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia
Santo André, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
Sao Jose Rio Preto, Brazil
Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira
São Paulo, Brazil
Centro Paulista de Oncologia S A
Vila Olímpia, Brazil
Biocenter
Concepción, Chile
Clinica Redsalud Vitacura
Santiago, Chile
China-Japan Friendship hospital
Beijing, China
The First Hospital of Jilin University
Changchun, China
Hunan Cancer Hospital
Changsha, China
Sichuan Cancer Hospital
Chengdu, China
West China Hospital, Sichuan University
Chengdu, China
Chongqing University Cancer Hospital
Chongqing, China
Nanfang Hospital of Southern Medical University
Guangzhou, China
Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
Hangzhou, China
Harbin Medical University Cancer Hospital
Harbin, China
Anhui Provincial Hospital
Hefei, China
The Second Hospital of Anhui Medical University
Hefei, China
Hong Kong Integrated Oncology Centre
Hong Kong, China
Cancer Hospital of Shandong First Medical University
Jinan, China
Hong Kong United Oncology Centre
Jordan, China
Linyi Cancer Hospital
Linyi, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Jiangsu Province Hospital
Nanjing, China
The Second People's Hospital of Neijiang
Neijiang, China
Shanghai East Hospital
Shanghai, China
Liaoning Cancer Hospital & Institute
Shenyang, China
Shanxi Provincial Cancer Hospital
Taiyuan, China
Tianjin Medical University General Hospital
Tianjin, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, China
Union Hospital of Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Xiangyang Central Hospital
Xiangyang, China
Institut Bergonié
Bordeaux, France
Hăpital Ambroise Pară
Boulogne-Billancourt, France
Hopital Albert Calmette - CHU Lille
Lille, France
Centre Leon Berard
Lyon, France
Hăpital Privă Du Confluent
Nantes, France
Chu Nantes - Hăpital Guillaume Et Renă Laă Nnec
Saint-Herblain, France
Institut de Cancerologie de L'Ouest
Saint-Herblain, France
Hăpital Foch
Suresnes, France
Universitaetsmedizin Mannheim
Manheim, Germany
Universtitaetsklinikum Essen
Nordrhein Westfalen, Germany
'Henry Dynant' Hospital Center
Athens, Greece
National and Kapodistrian University of Athens (Nkua)-University General Hospital Attikon
Athens, Greece
University General Hospital of Larissa
Larissa, Greece
University General Hospital of Patras
Pátrai, Greece
Special Anticancer Hospital of Piraeus 'Metaxa'
Piraeus, Greece
Queen Elizabeth Hospital
Hong Kong, Hong Kong
The University of Hong Kong
Hong Kong, Hong Kong
The Chinese University of Hong Kong
Shatin, Hong Kong
Mazumdar Shaw Medical Center
Bangalore, India
Narayana Superspeciality Hospital
Howrah, India
Yenepoya Medical College Hospital
Mangalore, India
Nirmal Hospital Private Limited
Surat, India
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi Irccs
Bologna, Italy
Fondazione del Piemonte per l'Oncologia IRCCS Candiolo
Candiolo, Italy
Istituto Nazionale Per La Ricerca Sul Cancro Di Genova
Genova, Italy
Presidio Ospedaliero Di Livorno
Livorno, Italy
Istituto Nazionale Tumori Regina Elena IRCCS
Roma, Italy
Saitama Medical University International Medical Center
Hidaka-shi, Japan
Kansai Medical University Hospital
Hirakata-shi, Japan
Hirosaki University Hospital
Hirosaki-shi, Japan
National Cancer Center Hospital East
Kashiwa-shi, Japan
St. Marianna University Hospital
Kawasaki-shi, Japan
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Japan
Saiseikai Kumamoto Hospital
Kumamoto, Japan
Kurume University Hospital
Kurume-shi, Japan
Matsusaka Municipal Hospital
Matsusaka-shi, Japan
NHO Okayama Medical Center
Okayama, Japan
Osaka City General Hospital
Osaka, Japan
Osaka International Cancer Institute
Osaka, Japan
Toho University Omori Medical Center
Ōta-ku, Japan
NHO Kinki-Chuo Chest Medical Center
Sakaishi, Japan
Keijinkai Teine Keijinkai Hospital
Sapporo, Japan
Tokyo Medical University Hospital
Shinjuku-ku, Japan
Shizuoka Cancer Center
Sunto-gun, Japan
Fujita Health University Hospital
Toyoake-shi, Japan
Wakayama Medical University Hospital
Wakayama, Japan
Kanagawa Cancer Center
Yokohama, Japan
Tottori University Hospital
Yonago-shi, Japan
Hospital Kuala Lumpur
Kuala Lumpur, Malaysia
Hospital Tengku Ampuan Afzan
Kuantan, Malaysia
Beacon Hospital Sdn Bhd
Petaling Jaya, Malaysia
Wojewodzki Szpital Im. SW. Ojca Pio W Przemyslu
Rzeszów, Poland
Unidade Local de Saude de Santa Maria, E.P.E. - Hospital Pulido Valente
Lisbon, Portugal
Colentina Hospital
Bucharest, Romania
Memorial Healthcare International S R L
Bucharest, Romania
S.C R.T.C Radiology Therapeutic Center S.R.L
Otopeni, Romania
National Cancer Center
Goyang-si, South Korea
Gyeongsang National University Hospital
Jinju, South Korea
CHA Bundang Medical Center, CHA University
Seongnam, South Korea
Seoul National University Bundang Hospital
Seongnam, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
The Catholic University of Korea, St. Vincent's Hospital
Suwon, South Korea
Hospital Universitari Dexeus
Barcelona, Spain
Hospital Universitari Vall d'Hebron - VHIO
Barcelona, Spain
Hospital Provincial de Castellon
Castellion, Spain
Hospital Universitario Clinico San Carlos
Madrid, Spain
Hospital Regional Universitario de Malaga
Málaga, Spain
Hospital Universitario Central de Asturias
Oviedo, Spain
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
Chi Mei Hospital, Liouying
Tainan, Taiwan
National Cheng Kung University Hospital
Tainan, Taiwan
Koo Foundation Sun Yat-Sen Cancer Center
Taipei, Taiwan
Taipei Veterans General Hospital
Taipei, Taiwan
Tri-Service General Hospital
Taipei, Taiwan
Chang Gung Memorial Hospital,Linkou
Taoyuan City, Taiwan
Phramongkutklao Hospital
Bangkok, Thailand
Chulabhorn Hospital
Laksi, Thailand
Rajavithi Hospital
Rajathevee, Thailand
Medical Park Seyhan Hospital
Adana, Turkey (Türkiye)
Hacettepe University Medical Faculty
Ankara, Turkey (Türkiye)
Charing Cross Hospital
London, United Kingdom
Trial contact
Contact for Trial Information
Contact information from ClinicalTrials.gov. Contact in English.
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.