RecruitingPhase III🇵🇱 PolandEN originalLung cancerHER2 positiveMetastatic / advanced

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

This clinical trial is designed to assess the efficacy and safety of trastuzumab deruxtecan (T-DXd; Enhertu®) in combination with pembrolizumab versus platinum-based chemotherapy in combination with pembrolizumab in participants with no prior therapy for locally advanced unresectable or metastatic non-squamous NSCLC, whose tumors have HER2-overexpressing and PD-L1 TPS \<50% without known AGA that have locally available therapies targeting their AGAs in first-line advanced/metastatic setting.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Pacjent musi mieć ukończone 18 lat.
  • Pacjent musi mieć potwierdzonego niedrobnokomórkowego raka płuca (nie-płaskonabłonkowego), który jest zaawansowany lub nieoperacyjny/z przerzutami (stadia IV, IIIB lub IIIC).
  • Guz pacjenta musi nadmiernie produkować białko HER2.
  • Guz pacjenta nie może mieć znanych mutacji, dla których istnieją dostępne terapie celowane.
  • Pacjent nie był wcześniej leczony systemowymi lekami przeciwnowotworowymi z powodu zaawansowanego lub przerzutowego raka płuca.
  • Pacjent wyraża zgodę na udział w badaniu.

✗ Disqualifies

  • Pacjenci, którzy byli leczeni za pomocą leków zawierających substancje czynne wpływające na enzym topoizomerazę I (np. niektóre chemioterapeutyki, leki typu ADC).
  • Pacjenci z mutacją HER2.

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 21, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (237)

Alaska Oncology & Hematology, LLC

Anchorage, United States

Orange Coast Memorial Medical Center Fountain Valley

Fountain Valley, United States

California Research Institute

Los Angeles, United States

Los Angeles Cancer Network (LACN)

Los Angeles, United States

Providence Medical Foundation

Santa Rosa, United States

Bay Pines VA Healthcare System

Bay Pines, United States

Lynn Cancer Institute Center

Boca Raton, United States

Holy Cross Hospital

Fort Lauderdale, United States

Mid-Florida Hematology & Oncology Centers, P.A.

Orange City, United States

BRCR Global Plantation

Plantation, United States

Cleveland Clinic Florida - Weston

Weston, United States

Piedmont Cancer Institute OneOncology

Atlanta, United States

The Queens Medical Center

Honolulu, United States

Hope and Healing Cancer Services

Hinsdale, United States

Dana-Farber Cancer Institute

Boston, United States

Mayo Clinic

Rochester, United States

Logan Health Research

Kalispell, United States

Renown Regional Medical Center

Reno, United States

Clinical Research Alliance

Westbury, United States

FirstHealth Cancer Center

Pinehurst, United States

Carolina Cancer Research Center

Wilson, United States

Gabrail Cancer Center

Canton, United States

St. Charles Health System

Bend, United States

University of Texas M. D. Anderson Cancer Center

Houston, United States

Lumi Research

Kingwood, United States

Summit Cancer Treatment Center

Spokane, United States

CINME - Centro De Investigaciones Metabolicas

Buenos Aires, Argentina

Hospital Italiano de Buenos Aires

Buenos Aires, Argentina

Instituto Argentino de Diagnostico y Tratamiento

Buenos Aires, Argentina

Instituto de Investigaciones Metabolicas (IDIM)

Buenos Aires, Argentina

Centro de Investigaciones Medicas y Desarrollo LC SRL (LC Investigacion)

Ciudad Autonoma Buenos Aires, Argentina

Instituto de Investigaciones Clinicas Cordoba S.A.

Córdoba, Argentina

Centro de Investigacion Pergamino SA

Pergamino, Argentina

Hospital Universitario Austral

Pilar, Argentina

Sanatorio Britanico S.A.

Rosario, Argentina

Instituto de Oncologia de Rosario

Rosario, Argentina

Instituto Medico de la Fundacion Estudios Clinicos

Rosario, Argentina

Sanatorio Parque S.A.

Rosario, Argentina

Instituto San Marcos

San Juan, Argentina

Grand Hôpital de Charleroi-Les Viviers

Gilly, Belgium

Chu Helora Hospital La Louvière Site Jolimont

La Louvière, Belgium

Chu de Liăge

Liège, Belgium

CHU Helora-Hospital de Mons

Mons, Belgium

Hospital de Cancer de Barretos - Fundacao Pio XII

Barretos, Brazil

Centro de Pesquisas Clinica Reichow

Blumenau, Brazil

CIONC-Centro Integrado de Oncologia de Curitiba

Curitiba, Brazil

CRIO - Centro Regional Integrado de Oncologia

Fortaleza, Brazil

Liga Norte-Rio-Grandense Contra o Câncer

Natal, Brazil

Hospital Ernesto Dornelles

Porto Alegre, Brazil

Hospital São Lucas da PUCRS

Porto Alegre, Brazil

Hospital Nossa Senhora Da Conceição

Porto Alegre, Brazil

Centro de Tratamento Oncologico (CTO)

Ribeirão Preto, Brazil

Hospital das Clínicas FMRP-USP

Ribeirão Preto, Brazil

Oncoclínicas Rio de Janeiro

Rio de Janeiro, Brazil

Instituto Dâor Pesquisa E Ensino - Rio de Janeiro

Rio de Janeiro, Brazil

Obras Sociais Irmã Dulce - Hospital Santo Antônio

Salvador, Brazil

CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia

Santo André, Brazil

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

Sao Jose Rio Preto, Brazil

Icesp - Instituto Do Câncer Do Estado de São Paulo Octavio Frias de Oliveira

São Paulo, Brazil

Centro Paulista de Oncologia S A

Vila Olímpia, Brazil

Biocenter

Concepción, Chile

Orlandi Oncologia

Santiago, Chile

Centro de Oncologia de Precision

Santiago, Chile

Hospital Clinico Universidad de Chile

Santiago, Chile

Centro de Investigacion Clinica Bradford Hill

Santiago, Chile

Clinica Redsalud Vitacura

Santiago, Chile

Beijing Cancer Hospital

Beijing, China

China-Japan Friendship hospital

Beijing, China

Jilin Cancer Hospital

Changchun, China

The First Hospital of Jilin University

Changchun, China

Hunan Cancer Hospital

Changsha, China

Sichuan Cancer Hospital

Chengdu, China

West China Hospital, Sichuan University

Chengdu, China

Chongqing University Cancer Hospital

Chongqing, China

Nanfang Hospital of Southern Medical University

Guangzhou, China

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine

Hangzhou, China

Harbin Medical University Cancer Hospital

Harbin, China

Anhui Provincial Hospital

Hefei, China

The Second Hospital of Anhui Medical University

Hefei, China

Hong Kong Integrated Oncology Centre

Hong Kong, China

Cancer Hospital of Shandong First Medical University

Jinan, China

Hong Kong United Oncology Centre

Jordan, China

Linyi Cancer Hospital

Linyi, China

The First Affiliated Hospital of Nanchang University

Nanchang, China

The Second Affiliated Hospital of Nanchang University

Nanchang, China

Jiangsu Province Hospital

Nanjing, China

The Second People's Hospital of Neijiang

Neijiang, China

Shanghai East Hospital

Shanghai, China

The First Hospital of China Medical University

Shenyang, China

Liaoning Cancer Hospital & Institute

Shenyang, China

Shanxi Provincial Cancer Hospital

Taiyuan, China

Tianjin Medical University General Hospital

Tianjin, China

Hubei Cancer Hospital

Wuhan, China

Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

Wuhan, China

Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Wuhan, China

Xiangyang Central Hospital

Xiangyang, China

Henan Cancer Hospital

Zhengzhou, China

CHU Angers - Hôpital Larrey

Angers, France

Institut Bergonié

Bordeaux, France

Hăpital Ambroise Pară

Boulogne-Billancourt, France

Hospices Civils de Lyon

Bron, France

Centre Hospitalier Intercommunal de Créteil

Créteil, France

Centre Georges Francois Leclerc

Dijon, France

Hopital Albert Calmette - CHU Lille

Lille, France

Centre Leon Berard

Lyon, France

Assistance Publique-Hôpitaux de Marseille

Marseille, France

Clinique Clementville

Montpellier, France

Hăpital Privă Du Confluent

Nantes, France

Hopital Bichat - Claude Bernard

Paris, France

Chu Nantes - Hăpital Guillaume Et Renă Laă Nnec

Saint-Herblain, France

Institut de Cancerologie de L'Ouest

Saint-Herblain, France

Hăpital Foch

Suresnes, France

Hopital Larrey

Toulouse, France

Universitatsmedizin Mainz

Essen, Germany

Klinikum Esslingen GmbH

Esslingen am Neckar, Germany

Universitaetsmedizin Mannheim

Manheim, Germany

Universtitaetsklinikum Essen

Nordrhein Westfalen, Germany

General Hospital of Athens of Chest Diseases "SOTIRIA"

Athens, Greece

'Henry Dynant' Hospital Center

Athens, Greece

National and Kapodistrian University of Athens (Nkua)-University General Hospital Attikon

Athens, Greece

University General Hospital of Larissa

Larissa, Greece

Metropolitan Hospital

Neo Faliro, Greece

St Luke's Hospital

Panórama, Greece

University General Hospital of Patras

Pátrai, Greece

Special Anticancer Hospital of Piraeus 'Metaxa'

Piraeus, Greece

General Hospital Papageorgiou

Thessaloniki, Greece

Interbalkan Hospital of Thessaloniki

Thessaloniki, Greece

Queen Elizabeth Hospital

Hong Kong, Hong Kong

The University of Hong Kong

Hong Kong, Hong Kong

The Chinese University of Hong Kong

Shatin, Hong Kong

Gleneagles Hospital Hong Kong

Wong Chuk Hang, Hong Kong

Mazumdar Shaw Medical Center

Bangalore, India

All India Institute of Medical Sciences

Bhubaneswar, India

Narayana Superspeciality Hospital

Howrah, India

Yenepoya Medical College Hospital

Mangalore, India

Deenanath Mangeshkar Hospital and Research Centre

Pune, India

Nirmal Hospital Private Limited

Surat, India

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi Irccs

Bologna, Italy

Fondazione del Piemonte per l'Oncologia IRCCS Candiolo

Candiolo, Italy

Ospedale Santa Croce

Fano, Italy

Istituto Nazionale Per La Ricerca Sul Cancro Di Genova

Genova, Italy

Presidio Ospedaliero Di Livorno

Livorno, Italy

Ospedale San Raffaele

Milan, Italy

Humanitas Istituto Clinico Catanese

Misterbianco, Italy

Azienda Ospedaliero-Universitaria S.Luigi Gonzaga

Orbassano, Italy

Azienda Ospedaliera S.Giovanni Addolorata

Roma, Italy

Istituto Nazionale Tumori Regina Elena IRCCS

Roma, Italy

Centro Ricerche Cliniche di Verona s.r.l.

Verona, Italy

Saitama Medical University International Medical Center

Hidaka-shi, Japan

Kansai Medical University Hospital

Hirakata-shi, Japan

Hirosaki University Hospital

Hirosaki-shi, Japan

National Cancer Center Hospital East

Kashiwa-shi, Japan

St. Marianna University Hospital

Kawasaki-shi, Japan

Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Japan

Saiseikai Kumamoto Hospital

Kumamoto, Japan

Kurume University Hospital

Kurume-shi, Japan

Matsusaka Municipal Hospital

Matsusaka-shi, Japan

NHO Okayama Medical Center

Okayama, Japan

Osaka City General Hospital

Osaka, Japan

Osaka International Cancer Institute

Osaka, Japan

Toho University Omori Medical Center

Ōta-ku, Japan

NHO Kinki-Chuo Chest Medical Center

Sakaishi, Japan

Keijinkai Teine Keijinkai Hospital

Sapporo, Japan

Tokyo Medical University Hospital

Shinjuku-ku, Japan

Shizuoka Cancer Center

Sunto-gun, Japan

Ehime University Hospital

Toon-shi, Japan

Fujita Health University Hospital

Toyoake-shi, Japan

Wakayama Medical University Hospital

Wakayama, Japan

Kanagawa Cancer Center

Yokohama, Japan

Tottori University Hospital

Yonago-shi, Japan

Gleneagles Hospital Penang

Jalan Pangkor, Malaysia

Hospital Kuala Lumpur

Kuala Lumpur, Malaysia

Hospital Tengku Ampuan Afzan

Kuantan, Malaysia

Beacon Hospital Sdn Bhd

Petaling Jaya, Malaysia

Wojewodzki Szpital Im. SW. Ojca Pio W Przemyslu

Rzeszów, Poland

Hospital da Luz

Lisbon, Portugal

Unidade Local de Saude de Santa Maria, E.P.E. - Hospital Pulido Valente

Lisbon, Portugal

Centro Hospitalar do Porto, E.P.E. - Hospital de Santo António

Porto, Portugal

Hospital CUF Porto

Porto, Portugal

Delta Health Care S.R.L

Bucharest, Romania

Colentina Hospital

Bucharest, Romania

Memorial Healthcare International S R L

Bucharest, Romania

Institutul Oncologic

Cluj-Napoca, Romania

Spitalul Clinic Militar de Urgenta Dr. "Constantin Papilian" Cluj-Napoca

Cluj-Napoca, Romania

Centrul de Oncologie Sfantul Nectarie Craiova

Craiova, Romania

Institutul Regional de Oncologie Lasi

Lasi, Romania

S.C R.T.C Radiology Therapeutic Center S.R.L

Otopeni, Romania

Spitalul Municipal Ploiesti

Ploieşti, Romania

Chungbuk National University Hospital

Cheongju-si, South Korea

National Cancer Center

Goyang-si, South Korea

Gyeongsang National University Hospital

Jinju, South Korea

CHA Bundang Medical Center, CHA University

Seongnam, South Korea

Seoul National University Bundang Hospital

Seongnam, South Korea

Severance Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

The Catholic University of Korea, St. Vincent's Hospital

Suwon, South Korea

Hospital del Mar

Barcelona, Spain

Hospital Clinic de Barcelona

Barcelona, Spain

ICO l'Hospitalet - Hospital Duran i Reynals

Barcelona, Spain

Hospital Universitari Dexeus

Barcelona, Spain

Hospital Universitari Vall d'Hebron - VHIO

Barcelona, Spain

Hospital Provincial de Castellon

Castellion, Spain

Complejo Hospitalario Universitario Insular-Materno Infantil

Las Palmas de Gran Canaria, Spain

Hospital Universitario Lucus Augusti

Lugo, Spain

Hospital General Universitario Gregorio Marañon

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital Universitario Clinico San Carlos

Madrid, Spain

Hospital Clinico Universitario Virgen de la Victoria

Málaga, Spain

Hospital Regional Universitario de Malaga

Málaga, Spain

Hospital Universitario Central de Asturias

Oviedo, Spain

Complejo Hospitalario Universitario de Santiago

Santiago de Compostela, Spain

Hospital Universitario Nuestra Señora de Valme

Seville, Spain

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Taiwan

Taichung Veterans General Hospital

Taichung, Taiwan

Chi Mei Hospital, Liouying

Tainan, Taiwan

National Cheng Kung University Hospital

Tainan, Taiwan

National Taiwan University Cancer Center

Taipei, Taiwan

Koo Foundation Sun Yat-Sen Cancer Center

Taipei, Taiwan

Taipei Veterans General Hospital

Taipei, Taiwan

Tri-Service General Hospital

Taipei, Taiwan

Chang Gung Memorial Hospital,Linkou

Taoyuan City, Taiwan

Siriraj Hospital

Bangkok, Thailand

Phramongkutklao Hospital

Bangkok, Thailand

Vajira Hospital

Dusit, Thailand

Songklanagarind Hospital

Hat Yai, Thailand

Chulabhorn Hospital

Laksi, Thailand

Rajavithi Hospital

Rajathevee, Thailand

Medical Park Seyhan Hospital

Adana, Turkey (Türkiye)

Gulhane Training and Research Hospital

Ankara, Turkey (Türkiye)

Hacettepe University Medical Faculty

Ankara, Turkey (Türkiye)

Medipol University Medical Faculty

Istanbul, Turkey (Türkiye)

Eastbourne District General Hospital

Eastbourne, United Kingdom

Charing Cross Hospital

London, United Kingdom

Altnagelvin Area Hospital

Londonderry, United Kingdom

Nottingham University Hospitals City Campus

Nottingham, United Kingdom

Trial contact

Contact for Trial Information

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/3/2026.

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