Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
This phase II trial tests how well a fixed dose combination (FDC) of cemiplimab and fianlimab before surgery (neoadjuvant) works in treating patients with stage IB-IIIB non-small cell lung cancer (NSCLC). The current standard of care (SOC) for NSCLC is to give chemotherapy and immunotherapy before going to surgery to have the cancer removed (neoadjuvant therapy). Immunotherapy with monoclonal antibodies, such as cemiplimab and fianlimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving a FDC of cemiplimab and fianlimab before surgery may kill more tumor cells in treating patients with stage IB-IIIB NSCLC.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18 lat lub więcej.
- •Zdiagnozowany nieoperacyjny rak płuca (NSCLC) w stadium IB-IIIB.
- •Niewielki lub umiarkowany stopień zaawansowania guza (T4 tylko jeśli wynika z wielkości powyżej 7 cm).
- •Poziom PD-L1 na komórkach raka wynosi co najmniej 1%.
- •Chirurg ocenił, że usunięcie guza jest możliwe operacyjnie.
- •Ogólny stan zdrowia pozwala na leczenie (grupa 0 lub 1 w skali ECOG).
✗ Disqualifies
- •Nowotwór płuca, który nie jest „niezłośliwym rakiem płuca” (non-small cell lung cancer).
- •Guzy T4 o innym charakterze niż tylko rozmiar.
- •Złe wyniki badań płuc, krwi lub wątroby.
- •Obecność zmian nowotworowych w miejscach wcześniej naświetlanych.
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- October 1, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (1)
Mayo Clinic in Rochester
Rochester, United States
Trial contact
Clinical Trials Referral Office
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 10/2/2026.
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