The Effect of Different Digestive Tract Reconstruction Methods on Postoperative Quality of Life After Proximal Gastrectomy
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
Gastric cancer ranks as the fifth most common malignancy worldwide and the fourth leading cause of cancer-related deaths. In China, its incidence and mortality rank third among all cancers. While the global incidence of gastric cancer is declining, proximal gastric cancer and adenocarcinoma of the esophagogastric junction (AEG) are on the rise. Due to the unique characteristics of AEG, there is no standardized treatment consensus, making the selection of an optimal surgical approach and reconstruction method crucial for improving patient outcomes. For early-stage proximal gastric cancer and AEG, total gastrectomy (TG) and proximal gastrectomy (PG) are common surgical options. PG, increasingly favored for its function-preserving benefits, has been shown to be a safe and effective alternative to TG. While TG effectively removes lymph nodes and reduces reflux risk, it leads to permanent loss of gastric function and nutritional deficiencies. PG better preserves gastrointestinal function but is limited by the risk of reflux esophagitis, highlighting the need for improved reconstruction techniques. Several reconstruction methods exist after PG, including esophagogastric anastomosis, jejunal interposition, double-tract reconstruction (DTR), double-flap technique (DFT), and tubular gastric anastomosis, each with varying efficacy in preventing reflux. Studies suggest that DTR reduces reflux and improves quality of life compared to esophagogastric anastomosis, while DFT, first introduced in 1998, has gained popularity for its advantages in maintaining nutrition and minimizing reflux. Additionally, tubular gastric anastomosis, which constructs a narrow gastric tube to facilitate tension-free anastomosis, has shown potential benefits for AEG patients. Most existing studies on laparoscopic or robot-assisted reconstruction techniques for proximal gastric cancer are retrospective, lacking high-quality prospective evidence. Furthermore, comparative data on their anti-reflux efficacy and postoperative quality of life remains l
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18-75 lat
- •Potwierdzony nowotwór górnej części żołądka lub połączenia przełyku i żołądka (badanie biopsji)
- •Guz o średnicy do 4 cm bez przerzutów
- •Dobry ogólny stan zdrowia (mogą być tolerować operację)
- •Brak wcześniejszego leczenia radiacyjnego, chemioterapii lub immunoterapii
- •Zgoda pacjenta na udział w badaniu na piśmie
✗ Disqualifies
- •Wcześniejsze operacje żołądka lub górnej części brzucha (z wyjątkiem operacji żółciowego)
- •Obecność przerzutów do odległych narządów
- •Ciąża lub okres karmienia piersią
- •Poważne choroby serca lub zawały w przeszłości
- •Inne nowotwory w ciągu ostatnich 5 lat (z wyjątkiem raka skóry)
- •Niekontrolowana epilepsja lub zaburzenia psychiatryczne
- •Niepełnosprawność ruchowa lub zaburzenia motoryczne
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- August 28, 2026
- Sex
- No restrictions
Locations (1)
First Hospital of Jilin University
Changchun, China
Trial contact
Quan Wang, Professor
Contact information from ClinicalTrials.gov. Contact in English.
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Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/29/2026.
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