RecruitingPhase II/III🇵🇱 PolandEN originalPancreatic cancerOther cancersMetastatic / advanced

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

⚠️

This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.

About the trial

The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.

Original English text from ClinicalTrials.gov

Who can (and can't) join

✓ Qualifies

  • Potwierdzony histologicznie guz neuroendokrynnny trzustki lub spoza trzustki, który się rozprzestrzenia lub nie można go operacyjnie usunąć
  • Stopień zaawansowania 1, 2 lub 3
  • Wcześniejsze leczenie zgodne z typem guza i stanem pacjenta
  • Widoczny wzrost guza na badaniach (CT lub MRI) w ciągu ostatnich 12 miesięcy
  • Guz mierzalny na badaniach obrazowych
  • Dostęp do próbki guza (ze starego zabiegu lub nowej biopsji, jeśli to bezpieczne)

✗ Disqualifies

  • Czerniak neuroendokrynnny, rak tarczycy, guz chromochłonny, rak komórek Merkla lub mieszany typ guza
  • Wcześniejsze leczenie inhibitorami kinazy tyrozynowej skierowanymi na receptory VEGFR
  • Wcześniejsze leczenie inhibitorami mTOR
  • Chemioterapia w ciągu 4 tygodni przed badaniem
  • Terapia radioaktywna wątroby w ciągu 4 tygodni przed badaniem
  • Bestrahlianie przerzutów w kościach w ciągu 2 tygodni przed badaniem

Simplified criteria — AI translation

Trial details

Minimum age
18 Years
Last updated (source)
July 22, 2026
Sex
No restrictions

Therapies / drugs in trial

Locations (117)

The University of Alabama at Birmingham

Birmingham, United States

Mayo Clinic Hospital

Phoenix, United States

The University of Arizona Cancer Center

Tucson, United States

Cedars-Sinai Medical Center

Beverly Hills, United States

Norris Comprehensive Cancer Center

Los Angeles, United States

Stanford Cancer Center

Palo Alto, United States

UCLA Health - Santa Monica Cancer Care

Santa Monica, United States

Kaiser Permanente Medical Center

Vallejo, United States

Georgetown University

Washington D.C., United States

Mayo Clinic - Florida

Jacksonville, United States

AdventHealth Orlando

Orlando, United States

Moffitt Cancer Center

Tampa, United States

University of Kentucky Markey Cancer Center

Lexington, United States

East Jefferson General Hospital

Metairie, United States

Dana-Farber Cancer Institute

Boston, United States

Henry Ford Cancer- Detroit

Detroit, United States

The Cancer and Hematology Centers

Grand Rapids, United States

Mayo Clinic

Rochester, United States

Siteman Cancer Center

St Louis, United States

University of Nebraska Medical Center

Omaha, United States

University of New Mexico Comprehensive Cancer Center

Albuquerque, United States

Roswell Park Cancer Institute

Buffalo, United States

Icahan School of Medicine at Mount Sinai

New York, United States

University of Rochester Medical Center

Rochester, United States

University of North Carolina at Chapel Hill

Chapel Hill, United States

Duke University Medical Center

Durham, United States

Sanford Roger Maris Cancer Center

Fargo, United States

University Hospitals Cleveland Medical Center

Cleveland, United States

The Ohio State University Comprehensive Cancer Center

Columbus, United States

Oregon Health and Science University

Portland, United States

University of Pennsylvania

Philadelphia, United States

University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center

Pittsburgh, United States

University of Tennessee Medical Center

Knoxville, United States

Henry-Joyce Cancer Clinic

Nashville, United States

Texas Oncology- Baylor Charles A. Sammons Cancer Center

Dallas, United States

Huntsman Cancer Institute, University of Utah

Salt Lake City, United States

University of Virginia

Charlottesville, United States

Virginia Cancer Specialists - Fairfax Office

Fairfax, United States

Fred Hutchinson Cancer Center

Seattle, United States

Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, United States

Monash Health

Clayton, Australia

Royal Brisbane and Women's Hospital

Herston, Australia

Peter MacCallum Cancer Centre

Melbourne, Australia

Fiona Stanley Hospital

Murdoch, Australia

GenesisCare North Shore

St Leonards, Australia

The Queen Elizabeth Hospital

Woodville South, Australia

Medical University of Graz

Graz, Austria

Paracelsus Medical University Hospital Salzburg

Salzburg, Austria

Medical University of Vienna

Vienna, Austria

Institut Jules Bordet

Brussels, Belgium

UZ Leuven

Leuven, Belgium

Cliniques Universitaires Saint-Luc (UCLouvain)

Woluwe-Saint-Lambert, Belgium

Verspeeten Family Cancer Center - London Health Sciences Centre

London, Canada

The Ottawa Hospital Cancer Center

Ottawa, Canada

Sunnybrook Health Sciences Centre

Toronto, Canada

Humanity and Health Clinical Trial Centre

Hong Kong, China

Prince of Wales Hospital

Hong Kong, China

Queen Mary Hospital

Hong Kong, China

Centre Hospitalier Universitaire de Caen Normandie

Caen, France

CHU Beaujon

Clichy, France

Centre Hospitalier Universitaire (CHU) de Lille - Hôpital Claude Huriez

Lille, France

Hospices Civils de Lyon

Lyon, France

Hôpital Timone

Marseille, France

CHU de Montpellier Hôpital Saint Eloi

Montpellier, France

Centre Hospitalier Universitaire Nantes

Nantes, France

Centre Eugéne Marquis

Rennes, France

CHRU Strasbourg Hôpital Hautepierre

Strasbourg, France

Centre Hospitalier Universitaire (CHU) Toulouse

Toulouse, France

Gustave Roussy

Villejuif, France

Evangelische Lungenklinik

Berlin, Germany

Universitätsklinikum Gießen und Marburg GmbH, Standort Marburg

Marburg, Germany

Universitätsklinikum Tübingen

Tübingen, Germany

University Hospital Würzburg

Würzburg, Germany

Azienda Ospedaliero-Universitaria Di Bologna IRCCS Istituto Di Ricerca E Di Cura A Carattere Scientifico

Bologna, Italy

Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST s.r.l.

Meldola, Italy

Instituto Europeo di Oncologia

Milan, Italy

Istituto Nazionale Tumori IRCCS - Fondazione Pascale

Naples, Italy

Azienda Ospedaliero-Universitaria San Luigi Gonzaga

Orbassano to, Italy

Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone

Palermo, Italy

Azienda Ospedaliero-Universitaria Policlinico Umberto I

Roma, Italy

Het Netherlands Kanker Institut (NKI)/ Antoni van Leeuwenhoek

Amsterdam, Netherlands

Amsterdam UMC

Amsterdam, Netherlands

Maastricht Universitair Medisch Centrum

Maastricht, Netherlands

Maxima Medisch Centrum

Veldhoven, Netherlands

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy, Oddział w Gliwicach

Gliwice, Poland

Śląskiego Uniwersytet Medyczny w Katowicach

Katowice, Poland

Samodzielny Publiczny Zakład Opieki Zdrowotnej Szpital Uniwesytecki w Krakowie

Krakow, Poland

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Warsaw, Poland

FutureMeds Wrocław

Wroclaw, Poland

Pan American Center for Oncology Trials, LLC

San Juan, Puerto Rico

FDI Clinical Resesarch

San Juan, Puerto Rico

Korea University Anam Hospital

Seoul, South Korea

Seoul National University Hospital

Seoul, South Korea

Severence Hospital, Yonsei University Health System

Seoul, South Korea

Asan Medical Center

Seoul, South Korea

Samsung Medical Center

Seoul, South Korea

Hospital Universitario Vall D'Hebron

Barcelona, Spain

Hospital General Universitario Gregorio Marañón

Madrid, Spain

Hospital Universitario Ramón y Cajal

Madrid, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitario La Paz

Madrid, Spain

Hospital General Universitario J.M Morales Meseguer

Murcia, Spain

Hospital Universitario Central de Asturias

Oviedo, Spain

Hospital Universitario Marqués de Valdecilla

Santander, Spain

Hospital Clínico Universitario de Santiago de Compostela

Santiago de Compostela, Spain

Hospital Universitario Vigen Del Rocío

Seville, Spain

Hospital Universitario y Politécnico La Fe

Valencia, Spain

Hospital Universitario Miguel Servet

Zaragoza, Spain

University Hospitals Birmingham NHS Foundation Trust

Birmingham, United Kingdom

Velindre Cancer Center

Cardiff, United Kingdom

NHS Greater Glasgow and Clyde

Glasgow, United Kingdom

The Clatterbridge Cancer Centre

Liverpool, United Kingdom

Guy's and St Thomas' NHS Foundation Trust

London, United Kingdom

King's College Hospital NHS Foundation Trust

London, United Kingdom

Oxford University Hospitals NHS Foundation Trust

Oxford, United Kingdom

Sheffield Teaching Hospitals NHS Foundation Trust

Sheffield, United Kingdom

Swansea Bay University Health Board

Swansea, United Kingdom

Trial contact

Backup or International

Contact information from ClinicalTrials.gov. Contact in English.

Share this trial

Data from ClinicalTrials.gov. AI-assisted translation, last sync: 7/10/2026.

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