Investigating Multigene Methylation Dynamics in Treatment Response Surveillance for Esophageal Carcinoma
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The primary objective is to determine whether pretreatment-to-posttreatment changes in circulating multigene methylation levels correlate with objective response rates (ORR) assessed by contrast-enhanced CT/MRI and levels of serum tumor markers. Secondary endpoints include: (a) time-dependent association between methylation fluctuation patterns and progression-free survival (PFS), (b) comparative diagnostic accuracy of methylation indices versus conventional biomarkers, and (c) feasibility of using methylation thresholds to guide adaptive therapy modification.
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Wiek 18-75 lat
- •Potwierdzony rak przełyku (wynik badania histologicznego)
- •Brak przebytych innych nowotworów (z wyjątkiem czerniaków skóry)
- •Brak przerzutów raka do innych narządów
- •Wcześniej nie leczony (bez chemioterapii, operacji czy radioterapii)
✗ Disqualifies
- •Oczekiwana długość życia poniżej 6 miesięcy
- •Poważne problemy psychiczne lub zaburzenia umysłu
- •Osoby niezdolne do samodzielnego podejmowania decyzji bez opiekuna prawnego
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Maximum age
- 75 Years
- Last updated (source)
- August 27, 2026
- Sex
- No restrictions
Therapies / drugs in trial
Locations (9)
Gansu Wuwei Cancer Hospital
Wuwei, China
Cancer Hospital Affiliated to Shantou University Medical College
Shantou, China
Zhaoqing Gaoyao District People's Hospital
Zhaoqing, China
Henan Cancer Hospital
Zhengzhou, China
Tangdu Hospital
Xi'an, China
Xijing Hospital
Xi'an, China
The First Affiliated Hospital of Yan'an University
Yan’an, China
The First Affiliated Hospital of Shanxi Medical University
Taiyuan, China
General Hospital of Western Theater Command, People's Liberation Army (PLA)
Chengdu, China
Trial contact
Zhongyang Zhang
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 8/28/2026.
You can help another person
We fund the Radar, this site, and the development of our Grosz dla Życia fundraising platform from donations and our own resources. Every contribution, even a small one, really helps.