A Study of GSK5458514 Administered Alone or In Combination With Other Anti-Cancer Agents in Participants With Prostate Cancer
This is not medical advice. AI-assisted translation — inaccuracies may occur. Always verify the original and consult your oncologist before taking any steps.
About the trial
The goal of the study is to evaluate how safe and how well the body handles GSK5458514 when administered in participants with prostate cancer. The study will be conducted in two parts - Part 1 (dose escalation phase) and Part 2 (dose expansion phase).
Original English text from ClinicalTrials.gov
Who can (and can't) join
✓ Qualifies
- •Mężczyzna w wieku co najmniej 18 lat
- •Zgoda na udział w badaniu i przestrzeganie wymogów badania
- •Potwierdzony rak gruczołowy prostaty z przerzutami
- •Rak prostaty oporny na hormonalne leczenie (castration-resistant)
- •Wcześniejsze leczenie nowymi lekami hormonalnymi bez skutku
- •Wcześniejsze leczenie chemioterapią (1-2 schematy) bez skutku
- •Co najmniej jeden widoczny guz zmiany miękkich tkanek
- •Chęć zapobiegania ciąży u partnerki (abstynencja lub antykoncepcja)
Simplified criteria — AI translation
Trial details
- Minimum age
- 18 Years
- Last updated (source)
- September 18, 2026
- Sex
- Male only
Therapies / drugs in trial
Locations (20)
GSK Investigational Site
Phoenix, United States
GSK Investigational Site
Denver, United States
GSK Investigational Site
New Haven, United States
GSK Investigational Site
Rochester, United States
GSK Investigational Site
East Brunswick, United States
GSK Investigational Site
Nashville, United States
GSK Investigational Site
Toronto, Canada
GSK Investigational Site
Montreal, Canada
GSK Investigational Site
Montreal, Canada
GSK Investigational Site
Lyon, France
GSK Investigational Site
Villejuif, France
GSK Investigational Site
Kanagawa, Japan
GSK Investigational Site
Tokyo, Japan
GSK Investigational Site
Tokyo, Japan
GSK Investigational Site
Badajoz, Spain
GSK Investigational Site
Barcelona, Spain
GSK Investigational Site
Madrid, Spain
GSK Investigational Site
Madrid, Spain
GSK Investigational Site
Málaga, Spain
GSK Investigational Site
Pozuelo de AlarcOn Madr, Spain
Trial contact
US GSK Clinical Trials Call Center
EU GSK Clinical Trials Call Center
Contact information from ClinicalTrials.gov. Contact in English.
Share this trial
Data from ClinicalTrials.gov. AI-assisted translation, last sync: 9/19/2026.
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